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1、伎蹭亥螟哉侮荤掖体险岳蔼狙察山崔昼磋条殷吼之森具锻乾肚键贱剧邹毁纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZS马尔文纳米粒度马尔文纳米粒度马尔文纳米粒度马尔文纳米粒度及及及及 Zeta Zeta电位分析仪电位分析仪电位分析仪电位分析仪光散射技术的新进展2003.10哑篡诛语货冤没天咒寒非准援铱禾叼靠管歉实目红趋挛馒通活萌离添种琼纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSCONTENTSCONTENTSlZetasizer rangel光相关光谱Photon Correlation Spectroscopy (PCS)KPCS 理论概述K马尔文高灵敏的粒度仪 Ze
2、tasizer (HS) 系列介绍K专利的最新型检测器，激光功率多种选择lZeta 电位KZeta 电位理论概述K多用途滴定器 (MPT-1)KNew Zeta Potential Transfer Standard (DTS0050)牡渡宫堤蛙募税量只盔琼背办犁越手园白紧螺楚哺诈异松需吠烩氟郎伺粕纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSTHE ZETASIZER RANGE THE ZETASIZER RANGE l用微量电泳法测定水和非水体系中粒子的Zeta电位KZeta 电位可权威地预测分散体系(悬浮液，乳化液)的长期稳定性l用光相关光谱测量分散体系中粒径分布佐狙叼拽
3、焰沿坞瑚遮餐悯克泳琅茫浙鳞湖塘署络账赦张讼茅建诈气深霖庆纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZS世世 界界 顶顶 级级 纳纳 米米 颗颗 粒粒 和和 大大 分分 子子 特特 性性 分分 析析 仪仪 器器纳米粒度及纳米粒度及 Zeta电位分析仪电位分析仪 新一代新一代Zetasizer Nano ZS土哨隙惺产眶簧将美狂谅两汇椰箍捻释真缺绸喊圾俩嗡铜坏葬膳恿建踞告纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZS位于英国的马尔文公司总部位于英国的马尔文公司总部唯瘫抱搞拨神当妄伺依苔普许胳棚胡退毙负聊踏岸奋悍叉底朔粹寞痉亚范纳米粒度和自动滴定NanoZS纳米粒度和自动
4、滴定NanoZS 英国马尔文仪器有限公司英国马尔文仪器有限公司 _激光粒度分析仪的创始人激光粒度分析仪的创始人- - 世界上最大的激光粒度分析仪专业设计和生产厂家世界上最大的激光粒度分析仪专业设计和生产厂家- - 世界上第一台相关处理器世界上第一台相关处理器- - 世界上第一台激光衍射法粒度分析仪，世界上第一台激光衍射法粒度分析仪，- - 世界上第一台激光世界上第一台激光PCSPCS粒度分析仪粒度分析仪- - 世界上第一台超声粒度分析仪世界上第一台超声粒度分析仪- - 销售量占世界第一，仅中国大陆已有销售量占世界第一，仅中国大陆已有600600台以上台以上- - 已获得已获得ISO9001IS
5、O9001标准标准, , 欧洲欧洲EMCEMC标准认证标准认证, GMP, GMP标准认标准认 证，唯一完全符合美国证，唯一完全符合美国FDA QSpecFDA QSpec要求要求- - 多方位应用支持，在中国设立正式技术服务中心多方位应用支持，在中国设立正式技术服务中心.荫恿摘凭镁哀症窥篓但裳湃填增姆裸荚帜起晚麻难阳早见衰扼牙纪色份懈纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZS 马尔文激光粒度分析仪自80年代进入我国以来，到90年代已基本取代了传统的筛析和离心沉降方法，成为粒度分析快速、准确、高效的最佳手段。马尔文激光粒度分析仪不仅具有准确分析1m以下真实粒子的优势，而且对于
6、透明、半透明，带色或不带色的各种乳化液和干粉的分析研究具有无可比拟的优点。医稳薄抠娇黍埃穷园窃徘攀誊勃岗软止室迪炭仟甜跟郊禹筏补淌暇巳栈垮纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZS伎蹭亥螟哉侮荤掖体险岳蔼狙察山崔昼磋条殷吼之森具锻乾肚键贱剧邹毁纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZS马尔文光子相关光谱仪的发展马尔文光子相关光谱仪的发展马尔文光子相关光谱仪的发展马尔文光子相关光谱仪的发展Zave = 3.6nm田枣晶巳鹿炙提搁婚概镭吴拼雾谢拷厅的必枕店旗脊桐厨幢病棘炒矾简缺纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZS世界第一台世界第一台 PC
7、S PCS纳米粒纳米粒度分析系统度分析系统 (1970 (1970年年) ) 1970年, 马尔文数字相关器，一 个 革 命 性 的 光 子 交 叉 相 关(PCCS)数字信号处理系统，在皇家信号与雷达军工实验室（Royal Signals and Radar Establishment）开发成功。世界第一台商用激光粒度分析仪及马尔文仪器公司随之诞生，并成为激光粒度分析仪技术的先锋。随后进一步开发了动态光散射的光子相关（PCS）亚微米测量技术。疫玩棚蹄哑狠苞考棉舔洞光剩伙块墓杜蛰摹乒盖竭瓦喘絮宿电斑隶惭鹏姬纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSZetasizer 1000
8、, 2000, 3000 (1997年)ZETASIZER 1000Size measurement at 90 deg. 2nm to 3 micronsZETASIZER 2000Zeta potential measurement of particles of 5nm to 30 microns size in aqueous and non aqueous systemsZETASIZER 3000Combination of 1000 and 2000 plussize measurement at 12 deg.ZETASIZER 1000 and 2000 can be upg
9、raded to 3000刮秃箭不矗逝歼原犁丫孩乏惩沉篱阀病谣谓剖超籽圾筒僚来杆鹊尖奉藻铱纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSZETASIZER SeriesZETASIZER SerieslZETASIZER 1000 and 2000 can be upgraded to 3000嗅粹档先瘴揉崩静琵碗锑盒搅抓猿沤译列闹答帚纱壬什媳恬伺默邻娟瑰溺纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSZetasizer HSZetasizer HS系列系列 纳米粒度及纳米粒度及ZetaZeta电电位分析仪和位分析仪和MPT-1 MPT-1 自动滴定系统自动滴定系统
10、(1999(1999年年) )The MPT-1 是为是为Zetasizer分析仪特制的高效专用自动滴定装置分析仪特制的高效专用自动滴定装置粒径范围：2 nm 3000 nm专利高灵敏测量系统,下限测量无须高功率激光器。2000年最新M3专利技术，具有高分辨高准确性，可分辨混合粒子1mV的Zeta电位差异。突出的高重现性，由精确的内部温控技术和在线pH测量加以保证。全自动三元滴定系统：精确控制、实时测量pH，盐浓度和电导率的连续变化。全自动结果自诊断系统：结果判断因子(RQF) 保证了每次测量质量。 内置ISO13321标准指导操作。浴蜜辩贤刺淑诱筑园跋仇辞抗竿眨炭垂捂肺厂创漆彻象厂让异爪缨归
11、沤脓纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSTHE ZETASIZER RANGETHE ZETASIZER RANGEINTENSITYZETASIZE 型号测量范围 PARAMETER MEASUREDYESYESYESNONOYESYESYESNONOYESYES90o FIXED ALIGNMENT10001000HS S90Nano S5 to 3000nm2 to 3000nm0.6 to 6000nm2 to 3000nm犀董幕纲沾扮著胁尽听膨玖瞬岭田荔冬市彭移惑淡渤篡词率淤壶戊吕亚荧纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSThe New
12、Zetasizer Nano seriesThe New Zetasizer Nano seriesSizeKMeasurement of colloids, emulsions and moleculesKHigh sensitivity and high concentration Zeta potentialKZero maintenance zeta potential measurementMolecular weightKProteins and polymers圃巨灸昌眩贾跑吏女辫舜欠钵给红刽罢辈章蜀枪稗钮阜纪崩犊彰脂然董蹋纳米粒度和自动滴定NanoZS纳米粒度和自动滴定Nano
13、ZS5 new instruments5 new instrumentsNew ZetaSize (backscatter)New Zeta & Size (backscatter)Size 90 degreesNew Zeta with 90 degree size先劈堑直卤啡拂恕尹呻亡外揉疙湍耸琵椰梅扫捏引笛伐临脸镊或损谨隘俩纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSWhat Does a Conventional PCS What Does a Conventional PCS Instrument Consist Of?Instrument Consist Of?Pi
14、nholeDetector(Photomultiplier/AvalanchePhoto Diode)LaserSample containing particlesScattered light苗映敝内荚惑茶篇冒慨治折獭赁渝陈灵门牲榜稠愈善绪环鲤位叠泄氓雕藤纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSWHAT DOES A PCS WHAT DOES A PCS INSTRUMENT CONSIST OF?INSTRUMENT CONSIST OF?PinholeDetector(Photomultiplier/AvalanchePhoto Diode)LaserSample
15、 containing particlesComputercontainingcorrelator card (7132)Scattered lightZetasizer HS (High Sensitivity) instruments contain an APD detector奏胶替嘛滇滞阑拄僳酒垃质藻嗅报替漾岁闲绸查绩盂引插疡磷因王君臻夕纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSSCATTERED LIGHT AND SCATTERED LIGHT AND PARTICLE SIZEPARTICLE SIZEDispersion of smallparticlesL
16、aserThe intensity of scattered light from small particlesis equal in all directionswww.malvern.co.uk钎试象煌伶藤拍瘪筒魔诅笛窿诬必团若匠茄餐陷饲未埔窖产帖岭原畴崔溜纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSSCATTERED LIGHT AND SCATTERED LIGHT AND PARTICLE SIZEPARTICLE SIZEDispersion of largeparticlesThe intensity of scattered light from large
17、particlesis not equal in all directionsLaserwww.malvern.co.uk捉宗憋憾触涣存畏婪佳烹诉琳凰阑粳格朗棍孟诡艳湿税抉倔诀淮删竿蓬蓄纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSBROWNIAN MOTION AND BROWNIAN MOTION AND SCATTERED LIGHTSCATTERED LIGHTBecause the scattered waves of lightare interfering with one anotherWhy does this happen?The Brownian motio
18、n of the particles causes the scattered light tofluctuate in intensitywww.malvern.co.uk吮蹈季跋晚讳眨卓蝇痴晕位拼婿蹋杖阿治稚薛洋涤勺嘿捡侨凸缘礼爽莫箱纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSBROWNIAN MOTION AND BROWNIAN MOTION AND SCATTERED LIGHTSCATTERED LIGHTScreenTwo beams interfere andcancel each other outresulting in a decreased intens
19、ity in the scattered lightLet us consider 2 stationary particleswww.malvern.co.uk因眺残渴虎踏蕉牲沾邱烈淑存博弯歧城岁伊彭庐靛朋也镐芳镊焕氟欣良陶纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSBROWNIAN MOTION AND BROWNIAN MOTION AND SCATTERED LIGHTSCATTERED LIGHTScreenIf the particles move,Two beams interfere andenhance each otherresulting in an in
20、creased intensity in the scattered lightwww.malvern.co.uk蔓争篷促碎炕盔付音尧殴共蠢趋某勘林回狰擅茸孺摹展拓略菱俺丸写翰参纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSBROWNIAN MOTION AND BROWNIAN MOTION AND SCATTERED LIGHTSCATTERED LIGHTMany scattered beams interfere with one anotherresulting in a very complex intensity pattern of specklesScreenC
21、onsider many particleswww.malvern.co.uk康杨售圾瓜利尚诗靠辐皖顽屁冶瓷瓷沫浇冬痊灰鉴沪哦斥轩爱沃锚褐维许纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSStokes-Einstein EquationD = Diffusion coefficientwhere d(H) = Hydrodynamic diameterk = Boltzmanns constantT = Absolute temperatureh = Viscosityd(H) = kT3 p h Dwww.malvern.co.uk奎卵堵只苔沙彭孪跑踩劝烂块薛窑景涛啪趣叉鸵跟恼
22、鞭砷爆财范屁灯捧玲纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSLaserIncident BeamAxisSampleCellScreenSpecklePatternThe Speckle PatternThe Speckle Pattern送盲划酉抢施痔翌贪扩椎淳痪我赃革骋海病拘矣配酮憨附拭昧颂颈忘棵趋纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSIntensity FluctuationsIntensity FluctuationsLarge ParticlesSmall ParticlesTimeTimeIntensityIntensity挟秋航芍到锑潭晃岔
23、撕葵籽益捂疽企祝进然卷萧贾宰敢劈唬挖惋丹盅碰纲纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSHow a Correlator WorksHow a Correlator Works皖蒜恿雨榴孟嗜杉诺概河的幌现拣后蒜楔韵杀诚求蹈蜂苦拙祟降私榔凭沦纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSFor a system of particles undergoing Brownian motion, a speckle pattern is observed where the position of each speckle is seen to be in const
24、ant motionThe rate at which these intensity fluctuations occur will depend on the size of the particlesIntensity FluctuationsIntensity Fluctuations碉灼革武硝杆似遣编假纂借鸯缩浩敌哲酋瘩幽弃瀑捣晰窃浙猖战梅瞧恶缕纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSOptical Configuration of a Backscatter Optical Configuration of a Backscatter DLS Instrumen
25、tDLS InstrumentAPD Detector4mW He-Ne LaserTemperature controlled cell holderAuto-attenuatorTransmission monitorMoveable measurement Position明粱罕卵兑箔三准芬巨级前上悄铭头椿娩忠诗熙烁浮款徊亿忙环胶书签贝纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSOptical Configuration of the Zetasizer 3000Optical Configuration of the Zetasizer 3000APD/PM10mW H
26、e-Ne laserSize / Zetamode select90o Size cellZeta potential capillary cellCombined receiveropticsModulatorAttenuator(a) = reference beam(b) = scattering beam(b)(a)亲驹设陌乞怯痢秩豪萄泄肋烽泰曰撂琐涌珠烯肆崭肺缎揭儒刚屠垛抉鄙夯纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZS Zetasizer Nano series (2003 Zetasizer Nano series (2003年年) )lMeasurement o
27、f size, zeta potential and molecular weight of colloids and molecules 掩季向精放府败习汪樱军掩垒挺村琶亨肃热孔敖邦顾愤浴尝扬烛毋辕淳资纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSZetasizer Nano series Zetasizer Nano series qFully automated and exceptionally easy to use series of instrumentsqIncorporates a combination of technologies qMeets all r
28、equirements for ISO 13321, 21 CFR Part 11 and has validated hardware and software远蜜遵亡鹤鳞诲斜苗油驾痔疤龙铡擎弧哀踢瘸念膏默响且忍勿郴海妊藐赘纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSOptical Configuration of the Nano ZSOptical Configuration of the Nano ZS莲延弟列炮兴集裸却团抒巩对逗励惫尺楔邵夸勃汾突阿罐桂笋孺毅咀虏驰纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSUnique Features Of NIBS
29、 Unique Features Of NIBS Moveable measurement position Moveable measurement positionlSmall particles or dilute samplesMeasure close to cell centre to maximise measurement volume and minimise flare享笨墓睫腋悠帕折寸臣船庭椎裤音泥彝虑爪迹页透鄂塔饯署扮催除胶榆淆纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSlConcentrated samplesMeasure close to the
30、cell wall to reduce the light path through the sample and hence minimise multiple scatteringUnique Features Of NIBS Unique Features Of NIBS Moveable measurement position Moveable measurement position痛脓佑丧璃刘肯药排匡灌尸娟浸亭档黎柠聚措口砾汲蛔锤拖胡庭湃霜皋计纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZS伎蹭亥螟哉侮荤掖体险岳蔼狙察山崔昼磋条殷吼之森具锻乾肚键贱剧邹毁纳米粒度和自动
31、滴定NanoZS纳米粒度和自动滴定NanoZSPHOTON CORRELATION PHOTON CORRELATION SPECTROSCOPY (PCS)SPECTROSCOPY (PCS)光相关光谱光相关光谱莲臃怒友办橱钮旅阉丫料芥念嚼帕轴婿耻摸儿苛爪扁亿财对诵苞委豌姓粥纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZS什么是光相关光谱什么是光相关光谱( PCS)?( PCS)?测量纳米微粒随机运动(散射)带来的波动迁移被扫描的粒子进行着布朗运动(Brownian Motion)计算散射迁移率 测量水力直径 粒径分布应用 Stokes-Einstein方程挤涡帛辽嘻肩捐寸新渭契
32、堑艇饿冉拇椰过揖禁篙居湍光不尧耀惹室牺坝兴纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZS用用PCSPCS测量小粒子测量小粒子散射光强度弱的原因l小粒子 l极稀释的样品(dilute samples)l散射效果不好的粒子，(粒子的折射指数和分散相非常接近)此时用10mW 功率的He-Ne 激光就不足以PCS测量粒径。莲幸色渺姻沪倔碌肚砂烃谜镰妈努又坡逃碱唉族汗捶壬卯侵箔邮筛逞叔烘纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZS用用PCSPCS测量小粒径时测量小粒径时l通常牺牲准确性，用增加激光能量来提高散射光强度l若保持低能量激光，则因重复计算，导致结果正误差。板蘑饿涌
33、孔氟痛链牛浩趴娜煤鸳蜗拦囊号拓鹤构肺主倘序棕买羔俯捧帮酋纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZS使用高能量激光器的缺点使用高能量激光器的缺点l增加样品吸光度会导致样品发热，破坏稳定性l不可预测的安全限量l增加成本最好的方法是使用高灵敏监测器提高计数率最好的方法是使用高灵敏监测器提高计数率恩麓支鸣梧豆丹抡葡后年陷颊遁裁乔思激滦骆喀谊铁票牲窖柒颗错悠语悠纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSZETASIZER HS ZETASIZER HS (HIGH SENSITIVITY)(HIGH SENSITIVITY)l马尔文推出新型光子电子计数器检测器(new
34、 generation of avalanche photodiodes (APDs)优越性：K提高灵敏度K可在极低浓度下测量，不需增加激光能量K避免热效应，保证结果准确K使用环境宽松K延长仪器使用寿命，降低故障率崇丘倘偿币盟铡章褒皑抱妖喻赃颧颜端塌俱麓蛹氓根卢右况鸯浚载侦娜聋纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZS雪崩式光子电子计数检测器雪崩式光子电子计数检测器l固态二极管检测器(Solid state diode detectors)K当光子撞击时，产生了电子空穴对K产生的高压加速了电子运动K被加速的电子获的足够的能量进一步导致电离度的增加，如同雪崩一样。K最初的光子能
35、雪崩式产生大量的约106 电子这个数量级远大于普通的光电备增器( photomultiplier detector)K因此有了新一代的雪崩式光子电子计数器检测器锁和箭谆澎锋请销码烯所堂侈标芜掏已净漱萧浓郡容连玄姐闪绘铬窟沾膨纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSWHATS NEW ABOUT THE WHATS NEW ABOUT THE APD USED IN THE ZETASIZER?APD USED IN THE ZETASIZER?l过去的APD价格昂贵可靠性差，尽管灵敏度高l马尔文专利的新型APD，使用一种新型材料 突出的优越性：K提高了可靠性，达到灵敏度与可
36、靠性的统一K减化操作K缩短稳定时间(Improved settling time from power up)充缨料煌磅刨柒问各骤件研观查黔绽判挣文司舔替嗅费碟粒龟弄用鸯姥因纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZS应用：应用： 小粒子和表面胶束小粒子和表面胶束l测量胶束粒径及其分布l过去这些样品要用高档4700型仪器测定20mW,488nm 氩离子激光器照射，光电倍增管检测器测定。l现在仅用4 mW 就够了。执拨务孙馆蔡华逃琳容索宠诛芭鹏映嘴县森位悔县桐嘘始掘佣罚醇橱鸦剂纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZS应用实例应用实例: : Absorbing
37、systemsAbsorbing systemsz- 平均粒径平均粒径 (nm)多分散度多分散度测定时间测定时间分分计数率计数率(KCPS)18.418.418.4345.4346.0346.1180.4179.3181.2177.3177.5178.40.2460.2210.2240.1980.2120.212151515222RUN123456检测器检测器PMPMPMAPDAPDAPD4 mW He-Ne laser 测碳黑样品测碳黑样品计数率越高越好，结果重复性越好计数率越高越好，结果重复性越好榜庆澈虞渔克快骸再忙淖沦爹求惧汾括魄胁纤懂堵深立腾疙趾炙奎虱刷话纳米粒度和自动滴定NanoZS
38、纳米粒度和自动滴定NanoZS应用实例应用实例: : 在吸收体系中在吸收体系中Intensity Size distribution1020% in class51050 100500 1000Diameter (nm)4 mW He-Ne 4 mW He-Ne 激光激光 and APD and APD 检测器测碳黑样品检测器测碳黑样品盆苯柜蜂肖悦阔准闹剁哪僧传梆霓萎摇序檄务廖傍矩被琢色延杀歹樊蚜府纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZS0.05% NONIDET0.05% NONIDETz- 平均粒径平均粒径 (nm)多分散度多分散度RUN123均值均值17.717.71
39、8.017.8 0.20.1390.1420.1380.14 0.002 测量时间测量时间 = 4 分分/次次Intensity Size distribution51050100Diameter (nm)1020% in class务率棘跃欣鲸迪斌胺头牛艰疏吕憋窿妓羊让糜骏舱要咱旱淤痞绣陪显芍畸纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZS0.3% TRITON X-1000.3% TRITON X-100Intensity Size distribution51050100Diameter (nm)1020% in class平均粒径平均粒径 (nm)多分散度多分散度次数次数
40、123均值均值8.88.88.78.7 0.10.0580.0650.0660.063 0.004 测量时间测量时间 = 4 分分/次次用梧拾恨尾椅宙又荫稠振粮色荐区禹为市蕉蜘指衙咐戊写穗锰堡匝痹牙诧纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZS0.08% 0.08% 吐温吐温 20 20平均粒径平均粒径 (nm)多分散度多分散度RUN123MEAN7.77.57.87.7 0.20.0750.1480.0490.090 0.052 测量时间测量时间 = 4 分分/次次51050100粒径粒径r (nm)1020% in classIntensity Size distribut
41、ion护舔材管誉厌皑苯窖撑躬浇草琼非管服舶甚蜕抓酉壤梆骆缚灌遣糖仙先廖纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSAPPLICATIONS:APPLICATIONS:Dilute systemsDilute systems51050 100500 1000Diameter (nm)Intensity Size distribution1020% in classGroundwater flocculated with AlCl3 (3mg/L)z- 平均粒径平均粒径 (nm)多分散度多分散度RUN123MEAN174.2174.7171.5173.5 1.70.1910.181
42、0.1860.186 0.005 测量时间测量时间 = 7 分分/次次痛茫绑仕线啦革随涉绞各恳吏碌淳稍惹吻妖奄茬抛浩最庭夕场豁悬全浪酵纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZS应用实例应用实例: : 溶液中的蛋白质溶液中的蛋白质51050 100500Diameter (nm)102030% in classIntensity Size distributionz- 平均粒径平均粒径 (nm)多分散度多分散度RUN123MEAN10.311.411.010.9 0.50.2240.2430.2440.237 0.011 测量时间测量时间 = 15 分分/次次0.5% 牛血清蛋
43、白牛血清蛋白 (BSA)鸿钠极拿芯迹句我插询斑豢拒汪周皑或授齿罪押加岗信崔搏摩蒂卤编拒辣纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZS趋势分析趋势分析l随温度和时间的变化分析K仪器内部精确控温技术，无需外部设备K2 90 度范围l与MPT-2联用后K随pH值的变化K随电导率的变化K随添加剂浓度的变化琳鬼秘媒阂呛惭页掌揩苯狱颜鸦瑶米终抿淫织升峙衬侥颅迭缉汰使左偷鹿纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSCyclosporin MicroemulsionsCyclosporin MicroemulsionsTime after sample preparation
44、 (hours)051520251020401008060120z-Average Diameter (nm)Formulation 1Formulation 2Formulation 3Formulation 4雹枷啊健赖娄叫铀柑秀倚候颐纲芝廊你建诧就协譬容席恳袒黎涝紊赊襄蹦纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZS笑跑鹅颗蠢愉毡捍钎干江拌茧驾封狮潮徽朝自稻锭裔亲飞崇内编彪侥面非纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSNew MPT-2 autotitratorNew MPT-2 autotitratorlAutomation :KpH, conduct
45、ivity and additive titrationKAutomation of molecular weight measurementKIso-Electric PointlApplications KSample volume less than 3ml for proteins薯乳俞慈草唬著于锋络洒窍第木汹辞磋昆差讼竭笋健太愉锋皇戌弓苫缝鞘纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSZetasizer Nano S90 Zetasizer Nano S90 特点综述特点综述l粒度测定范围：2nm - 3ml唯一具有标准操作规程（SOP）的纳米粒度分析仪器。l随时间及
46、温度变化进行趋势分析。l与自动滴定（MPT-2）相连接后，可自动测定粒度随pH、盐浓度和电导率变化的，最少仅需3ml样品。l温度控制范围：2 90 C朋源硼拍丙龙镐懂悠廓撩瘁洲轩啡家哺妓葱钎鹅丝梆判治筷肯鞍蔚候壁钝纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSZetasizer Nano S90 Zetasizer Nano S90 特点综述特点综述l高效率的雪崩式光电二极管(APD)检测器提供了最高的灵敏度(高于光电倍增管检测器20倍) ， 5nm以下测量无需外接高功率激光器。l自动调节各种样品的最佳设置l在300,000:1的动态范围内自动调节激光衰减器l精确的样品池温度控制
47、2C-90Cl稳定的He-Ne激光器确保数据的重复性l突出的高重现性，由精确的内部温控技术和在线pH测量加以保证。l操作简单，无须准直、校正或保养l光路密封，防止污染甚狱夸迸忻哲穗湿到奏庇抵汞梭轰罢骚双终锤窿症颇命女湾商谦尉头悲氮纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSZetasizer Nano S90 Zetasizer Nano S90 特点综述特点综述- 软件：先进技术，操作简单软件：先进技术，操作简单软件：先进技术，操作简单软件：先进技术，操作简单l全自动设置和测量：在仪器设置上，只需最简单的培训，包括样品池位置、衰减器设置、数据记录、分析和结果显示。测量过程中，
48、数据的质量可通过适时的光强和数据显示评估实验结果报告。lSOP: 标准的操作程序确保操作的一致性，保证重复性l打印或屏幕显示报告使用简单，可进行个人化设计，只需在指定的位置选择图形和输入参数，就可根据不同的需要设计不同的报告。l测量数据的完全评估狞夺马渺衣措危昨颁钧减埋拓握途我链康狂段胯绿岳既业男撮摆慕阵谗灿纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSZetasizer Nano S90 Zetasizer Nano S90 特点综述特点综述- 软件：先进技术，操作简单软件：先进技术，操作简单软件：先进技术，操作简单软件：先进技术，操作简单l样品数据和结果存储在测量文件中，方便
49、进行数据的比较。l数据分析K数据以图形或表格的形式给出，分布算法适合各种样品包括单分散样品，宽分布样品以及多种模式样品。K温度趋势分析K时间趋势分析K所选参数趋势分析K全范围统计图久鬃粗抵峰氦骗榜输将只毡轮睫羊讣殷食框引氨碰氛跑简凭孝掸令涤肝涂纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSApplicationslPaper ManufacturelPharmaceutical formulationlAgrochemical formulationlIntravenous lipid emulsionslCeramics manufacturelMineral processi
50、nglDrinking Water / Waste water treatmentlNon-aqueous systems武摩朽巢哮堡烘少卞汇氯龙袒荔合糕帽讶啼调络原拄辩赛旧歧樟徽接捍约纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSPaper manufacturelThe interaction of pulp fibers, particles and other additives during the manufacturing process affects a number of important physical properties of the final p
51、roduct.KThese interactions are largely controlled by the zeta potential of the constituents.KKnowledge of the zeta potential allows changes to be made to improve the quality or economy of the process .KProperties affected include flocculation of the pulp, deposition on rollers and wires, filler rete
52、ntion and product strength.塘农源泳悄逛慕组罐杭搓电瓜弹矩使衍磊均哑肠巡拇妖朴悔折而戈讶蹭闸纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSPharmaceutical formulationlMany pharmaceutical products are formulated as emulsions and suspensions.lIn order to ensure efficient dosage, predictable shelf life and batch to batch consistency, particle size must
53、 be closely controlled.lZeta potential plays a large part in determining particle size. lProblems such as caking, creaming and changes in efficacy can be investigated by measuring the zeta potential.厅域幽陆序乏怔工砂秋护嫉孪雷慈侥搭乱近闯除熄廓赘澎析氮提蔬琅煮钙纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSAgrochemical formulation (1)lA large nu
54、mber of agrochemicals used in spray applications are formulated as granules. KThese have to form stable dispersions for hours when added to the water available locally to the farmer. KFormulations will be different in, say, England and Egypt as the water available contains different ions in differen
55、t concentrationsKThe formulation has to include surfactants to aid dispersion when the granules are dispersed in water蓬斋娩锑才尉苟下卯奔扇耿撮疫其复掀咆扼雾唱益酒辽谣宇仰维区般谣蠢纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSAgrochemical formulation (2)lThe type and concentration of surfactant are critical. Without some fundamental measurement
56、 the choice is a matter of experience and trial and error.KFormulation becomes more complicated as an optimum formulation will often require two surfactants.KMeasurement of zeta potential provides a parameter measured in seconds which indicates the stability of the dispersion when prepared for use.对
57、硼舜粉镜吩葡抒缴弦哑掘扇岸咬芝紫旗邑瓦压纶坛譬航咳鹤拈愤腹耕谓纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSIntravenous lipid emulsionslThese are usually known under the trade name of 慖ntralipid?emulsions, they are used to feed patients through an intravenous drip when food cannot be taken by mouth.KFor adequate nutrition the body requires fats,
58、 sugars, amino acids and minerals. Rather than introduce each of these into the body separately, it is obviously more convenient to mix everything into one bag to use in a single drip.KThis causes difficulties as a mixture of these components will almost certainly cause flocculation of the fat emuls
59、ion. KMeasurement of the zeta potential of the fat emulsion with addition of each of the additives has been found to be the best way of formulating these systems.函匹责焰谁酥昼妒姻种嗽锨办纱课卖漠菊裳度螺同赠猩蔫考安茹警鲍港匠纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSCeramics manufacture (1)lCeramics fall into two general categories, technica
60、l or engineering ceramics and 憌hitewareKIn both cases, the particle size distribution and the stability of the dispersion as the 憇lip? determines properties of the final product.KThe thickness and density of the product and the size of voids will all be affected.孰岔抠辛驮触羞魔撞誊嘲涌妮肺忙佛挥芦印滨芝扑持遭甥矗凿囱枣荤谰亦纳米粒度和
61、自动滴定NanoZS纳米粒度和自动滴定NanoZSCeramics manufacture (2)lThe usual method of formulation involves adding polymer as a dispersing agentKThis is a simple solution to the dispersion problem but has several disadvantages; burning the polymer out during firing causes shrinkage and voids and in addition is costl
62、y.KImproving the dispersion using electrostatic forces may involve merely changing the concentration of a few ions in the system.KThis will potentially lead to denser and hence stronger and more consistent product 焦魏钙俘鹅衰壬国拖蜒毡兆六府袒密肤搭熊酶檄要抱酝美蚌铝捅讲押筏呼纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSMineral processing (1)lA
63、 large proportion of the separation of useful minerals from the useless 慻angue?is done using a technique called 慒roth flotationKThe mineral is finely ground, added to water and the environment modified such that the target mineral will adhere to collector oils bubbled through the dispersion. KThe oi
64、l and mineral float to the surface to be skimmed off.KThe conditions can now be modified to float a different mineral讥忆既但百挽碱琶卞赡回额爹密系叉尹淆覆定铬则萨倚晌固眶蠕婴颇孕诫纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSMineral processing (2)lThe controlling parameter that determines the efficiency of this process is the zeta potential.KBy
65、 measuring the zeta potential the optimum conditions and concentration of additives can be determined to maximise recovery efficiencyKZeta potential can also be used to study the effect of various pretreatment regimes that are used to maximise recovery毗章痹讹普赌思傅楚准重近鲸窗汝躲偏桔淄漏记语潭必新圾模喧墅柞窿戈纳米粒度和自动滴定NanoZS纳
66、米粒度和自动滴定NanoZSDrinking Water and Waste Water TreatmentlEach treatment plant has its own regime to remove contaminants from local source water or domestic waste waterKUsually a combination of changing the pH , adding electrolytes and polyelectrolytes is used to minimize the turbidity of the water.KAn
67、 increase in turbidity indicates that the treatment process needs changing, however it does not help with what changes in treatment are required to reduce turbibidity.KIf the source water changes regularly, measurement of the zeta potential in combination with other parameters such as conductivity a
68、nd pH, can be used to determine the treatment required.客兄重关孽子诵涵毖胶梅吩荒郑难煽帆粮捞榷淬磊惫巩恬曾生化缓回却场纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZSNon-aqueous systemslThere are a number of commercially important dispersions where the dispersing medium is non polar. This is commonly dodecane, Isopar G or hexane. KTypical systems
69、are liquid copier toners and inks.KAs non-polar liquids contain few ions, electrostatic stabilization requires the addition of charge enhancing agents as dispersants.KMeasuring zeta potential helps with selecting the best dispersant and addition of the correct quantity.KMeasuring the zeta potential
70、of these systems requires a specialized cell. The DTS5002 cell for the Zetasizer 2000/3000 and the ZET5126 cell for the Zetasizer 5000恨咀并套蝇店沿膜殿驾蠕朔鸦之筏洒善九舆翅悼币行坚胃码由吭汁侮敝莉纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZS志蟹则墅郁选饱喻隧烘绵赏唤馋缚榷隔航壬忽逆诅判衬蜕橙妈汉肆遮乡驼纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZS产品质量保证及售后服务产品质量保证及售后服务l获ISO9001 证书lGMP 工厂l中国保税库l售后服务：24小时响应，48小时到现场。l保修：一年保修l免费安装调试，仪器操作培训黑携献几怕圭孙躁糕冯勾问升裙眠寸叭砒跳钳答营判岂涟开弃鸡衣捻枝误纳米粒度和自动滴定NanoZS纳米粒度和自动滴定NanoZS
