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1、图解脑疝北京天坛医院神经内科杜万良（reflexhammer）1高等课堂脑疝n是指在颅内压增高的情况下，脑组织通过某些脑池向压力相对较低的部位移位的结果，即脑组织由其原来正常的位置而进入了一个异常的位置。2高等课堂脑疝的类型：na.大脑镰疝 ： 一侧大脑半球占位病变可使同侧扣带回经大脑镰下缘疝入对侧，胼胝体受压下移。 n小脑幕切迹疝 b.前疝：也称颞叶沟回疝，是颞叶沟回疝于脚间池及环池的前部；后疝：颞叶内侧部疝于四叠体池及环池的后部；f.小脑幕切迹上疝：后颅凹占位病变时，小脑上蚓部可向上疝入小脑幕切迹的四叠体池。nc.中心疝：幕上压力增高，致使大脑深部结构及脑干纵轴牵张移位。 nd.颅外疝：
2、脑组织通过颅外缺损疝出。ne.枕骨大孔疝 ： 后颅凹占位病变时，可致小脑扁桃体疝入枕骨大孔。ng.蝶骨嵴疝：颅前凹和颅中凹的占位病变，由于病变部压力相对高一些，则额眶回可越过蝶骨嵴进入颅中凹，可颞叶前部挤向颅前凹。3高等课堂示意图na) subfalcial (cingulate) herniation ;镰下疝nb) uncal herniation ; 钩疝nc) downward (central, transtentorial) herniation ; 下行性小脑幕疝nd) external herniation ; 颅外疝ne) tonsillar herniation.扁桃体疝n
3、f) ascending transtentorial herniation (reversed tentorial)上行性小脑幕疝ng) sphenoid herniation蝶骨嵴疝4高等课堂类型脑疝部位命名别名疝入脑组织命名1大脑镰下疝扣带回疝2小脑天幕疝 前疝 后疝小脑幕切迹疝、小脑幕下降疝脚间池疝环池疝，四叠体疝颞叶钩回疝海马回疝3小脑幕孔中心疝间脑 4小脑幕孔上疝小脑幕上疝 小脑蚓部疝 5枕骨大孔疝小脑扁桃体疝 5高等课堂示意图6高等课堂解剖关系7高等课堂解剖关系FQcMb3vTOSyCClvFPOSpCClvss8高等课堂解剖关系FTCesPd4th VFTMbCes9高等课堂T
4、he suprasellar cistern & the quadrigeminal cisternnThe left and center images show the suprasellar cistern. Its anterior borders are formed by the frontal lobes (F). Its lateral borders are formed by the uncus (U) of the temporal lobes. The left image shows the 5-pointed star appearance of the supra
5、sellar cistern where the posterior border is formed by the pons (Po). The black arrow points to the fourth ventricle. The center image shows a higher cut where the suprasellar cistern has a 6-pointed star appearance since the posterior border is formed by the cerebral peduncles (P) which have a cent
6、ral cleft. nThe right image shows the quadrigeminal cistern (black arrow). Note the babys bottom appearance of its anterior border. When ICP is increased, the quadrigeminal cistern space is compressed or obliterated. 10高等课堂The suprasellar cistern& the quadrigeminal cistern. nThe midline sagittal MRI
7、 scan shows the levels of the axial diagrams. The quadrigeminal cistern is located above (anterior to) the Q in the highest cut shown (number 9). The anterior border of the quadrigeminal cistern is formed by the superior colliculi (c). Image 8 (lower cut) also shows the quadrigeminal cistern. In thi
8、s case, its anterior border is formed by the inferior colliculi (c). This gives the anterior border of the quadrigeminal cistern the appearance of a babys bottom. The quadrigeminal plate is comprised of the superior and inferior colliculi. The quadrigeminal cistern is posterior to this quadrigeminal
9、 plate, thus its anterior border may be formed by the inferior or superior colliculi. 11高等课堂镰下疝临床表现影像所见并发症头痛对侧下肢无力同侧额角截断大脑镰前份不对称同侧侧脑室腔消失透明隔移位因大脑前动脉卡压到大脑镰上引起同侧ACA供血区梗塞伴有其他疝12高等课堂Subfalcine herniation (cingulate herniation)Transtentorial herniation nThe suprasellar cistern (left image) is obliterated.
10、 The quadrigeminal cistern is very compressed and pushed posteriorly (center image). nA subdural hematoma with a midline shift is noted. There is central transtentorial and subfalcine herniation.13高等课堂ACA供血区梗塞14高等课堂Uncal herniation临床表现影像所见并发症同侧瞳孔散大、眼动受限（动眼神经受压）对侧偏瘫（同侧大脑脚受压）有时颞叶疝压迹会导致同侧偏瘫（对侧大脑脚受压。假定位
11、体征）对侧颞角增宽同侧环池增宽同侧桥前池增宽钩回进入鞍上池大脑后动脉受压导致枕叶梗塞15高等课堂鞍上池缺角16高等课堂冠状位CT与MRI17高等课堂海马旁回褶皱18高等课堂对侧颞角增宽19高等课堂同侧桥前池增宽20高等课堂同侧环池增宽21高等课堂Uncal herniation22高等课堂Uncal herniationnobliteration of the suprasellar cistern (red arrow) and the quadrigeminal cistern (green arrow)23高等课堂Uncal herniationnThe ipsilateral vent
12、ricle, sulci, fissures are compressed and obliterated, isappeared.nobliteration of the suprasellar cistern(s) and quadrigeminal cistern(q)24高等课堂Uncal herniationnAcute infarctionn1st daynAcute infarction n4th daysq25高等课堂Uncal herniationnBefore surgery, a big GBM in the left temporal lobe with uncal h
13、erniation.nAfter surgery, the GBM was removed, the suprasellar cistern and quadrigeminal cisterns are normal.26高等课堂Uncal herniationnAcute infarction of right posterior artery (PCA), this is a complication of uncal/transtentorial herniation, because the PCA was compressed by brain herniation.27高等课堂双侧
14、大脑后动脉梗塞28高等课堂双侧大脑后动脉梗塞29高等课堂Durette hemorrhage 30高等课堂Durette hemorrhage31高等课堂Kernohans notch颞叶疝压迹32高等课堂Uncal herniationnWhen mass effects within or adjacent to the temporal lobe occur, the medial portion of the temporal lobe (uncus) is forced medially and downward over the tentorium. There is ipsila
15、teral pupillary dilation. The uncus is pushed medially into the suprasellar cistern. There is bilateral uncal herniation. The suprasellar cistern is obliterated.33高等课堂early uncal herniation nThe right uncus is pushing into the suprasellar cistern; early right uncal herniation. 34高等课堂中心疝临床表现影像所见并发症意识
16、改变呼吸模式改变去皮层、去脑小瞳孔因脉络膜前动脉受压引起苍白球和视束梗塞35高等课堂中心疝36高等课堂Superior vermian herniation ( ascending transtentorial herniation )n由于后颅凹的占位效应，小脑蚓和小脑半球通过小脑幕切迹向上移动临床表现影像所见并发症恶心呕吐意识障碍中脑外观呈陀螺状双侧环池变窄四叠体池充满因小脑上动脉受压引起梗塞Galen静脉移位脑积水意识障碍迅速出现，并可能死亡37高等课堂陀螺状外观38高等课堂双侧环池变窄39高等课堂四叠体池充满40高等课堂不露齿的微笑41高等课堂皱眉42高等课堂第一天的四叠体池和环池43
17、高等课堂第二天，四叠体池和环池消失44高等课堂脑积水45高等课堂ascending transtentorial herniation46高等课堂枕大孔疝临床表现影像所见并发症双侧上肢感觉减退意识障碍轴位像见到小脑扁桃体位于齿状突水平矢状位见到小脑扁桃体低于枕大孔5mm（成人）或7mm（儿童）小脑扁桃体出血性坏死意识障碍和死亡47高等课堂枕大孔疝48高等课堂Tonsillar herniation nIn tonsillar herniation (rare), a mass effect in the posterior fossa causes the cerebellar tonsils
18、 to herniate inferiorly through the foramen magnum compressing the medulla and upper cervical spinal cord. Conscious patients complain of neck pain and vomiting. They may have nystagmus, pupillary dilatation, bradycardia, hypertension and respiratory depression. Early tonsillar herniation is difficu
19、lt to recognize in an unconscious patient. It may not be evident on CT scan since axial views cannot see the pathology well. It is best seen on sagittal MRI. Clinically changes in vital signs may be the only clinical clue in an unconscious patient.49高等课堂Tonsillar herniation50高等课堂a male patient in hi
20、s 30s who died of brain stem herniation after completing a marathon. nThe CT shows (A) loss of the rostral cerebral sulci suggesting increase in ICP, (B) and (C) a large hydrocephalus with widening of both temporal horns. The grey matter can still be differentiated from the white matter, but all sul
21、ci are lost. This suggests that the brain oedema is of relative recent onset and massive tissue ischaemia has not yet occurred. (D) Compression of the fourth ventricle with dilatation of the third ventricle and the caudal aspect of both temporal horns. This is observed with considerable brain oedema
22、 and obstructive hydrocephalus. (E) Herniation of the medulla and pons into the foramen magnum. (F) The tonsils are located at the level of the dens which is a good indicator for foramen magnum herniation.51高等课堂n(A) The disc shows florid hemorrhages with relatively little swelling, indicating a rapi
23、d, dramatic increase in CSF pressure. Progressive changes of optic disc oedema are seen in a patient with an intracranial tumour who declined treatment (B-D). (B) Early nerve fiber dilatation is seen particularly superiorly, inferiorly and nasally. (C) This increases and venous engorgement develops.
24、 (D) Temporal nerve fiber dilatation and swelling of the disc increases and hemorrhages appear. (E) In gross chronic disc oedema the normal retinal vasculature is masked and dilated superficial capillaries are observed. (F) In atrophic optic disc oedema nerve fibers are eventually destroyed and the
25、optic disc without viable nerve fibers does not swell. This patient had longstanding benign intracranial hypertension. Retinochoroidal venous collaterals are present (black arrowhead). 52高等课堂颅外疝53高等课堂核磁选择n1. Subfalcine herniation. This is best seen on coronal MR images.n2. Descending transtentorial
26、herniation (uncal herniation, hippocampal herniation). best seen on coronal images, but the compression of the brainstem is best observed on axial T2-WI.n3. Ascending transtentorial herniation. The sagittal imaging plane is preferred.n4. Cerebellar tonsillar herniation. Sagittal and coronal imaging planes are preferred.54高等课堂55高等课堂56高等课堂小结n占位效应引起的脑组织移位n影像上识别脑疝的关键是看脑池的变化57高等课堂
