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1、索非不韦杂质结构列表15-11-isomcr-l15-9-is omer-315-11-iso mer-215-11 -isomer-315-11-isorrier-415-9-is omer-515-11-isomen5吟 eosilvsloHorogrNH工轄N,a)EO 匸 ueu 平 L lldLEeEOSlLLlALgLauJQSlLLlnLBloUJOSls LGaEOS.SL HfioTNEO皀 6SL01ALs二usl.Ho?。rNHO(S)PhOOO (S)HN(R)PhOHR)O(S)住 N OO (S) N(R)严HO (R) f f15-isomer-4O P.亠OO
2、叽，a OP ,HN(S)PhOH N15-isomer-6OHO (R)15-isomer-7.H15-G-isomer-1S,R15-G-ismer-2PhO(R)OOR,R15-G-ismer-315-11-isomer-3OHRihNpOTPH o o QO HNOR)OMslOH(rLoh15-isomer-1215-isomer-1315-11-isomer-4O- PH o15-isomer-1415-11-isomer-5OT PH o15-isomer-15(R) F(S)OH0 N(R)HN (R)0 0H 015-11-isomer-6一、(R)(ShHO N (R)HN -(R) OO -O15-isomer-16HN - (S)0015-11-isomer-7OH(R) 0HHN (S)OO15-isomer-18其他杂质:OOOO15-B15-C15-e nan tiomer- （S）-（R）OHO - N ,（R）HN F.（R）OOHO15-11-isomer-215-11-isomer-215-11-isomer-4
