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1、外周T细胞淋巴瘤的事实 No. 25 in a series providing the latest information for patients, caregivers and healthcare professionals 系列中的第25号患者，医护人员以及医疗专业人员提供最新信息 Highlights 亮点 Peripheral T-cell lymphomas (PTCLs) comprise a diverse group of uncommon and aggressive diseases 外周T细胞淋巴瘤（PTCLs）包括一个罕见的和积极的疾病不同群体 in which
2、 the patients T cells become cancerous. 在病人的T细胞发生癌变。 T-cell lymphomas account for between 10 percent and T细胞淋巴瘤占10至 15 percent of all non-Hodgkin lymphomas (NHLs). 15的所有非霍奇金淋巴瘤（NHLs）。 The World Health Organization (WHO) divides PTCLs into three categories, nodal, extranodal and 世界卫生组织（WHO）的划分为三类PTCL
3、s，淋巴结，结外和 leukemic, and has classified 13 major subtypes of PTCLs. 白血病，并已列为13 PTCLs主要亚型。 Getting an accurate diagnosis and knowing 获取准确的诊断和了解 your PTCL subtype is important. 您的PTCL的亚型是很重要的 。 PTCLs are rare in the United States and are more common in Asia, Africa and the Caribbean, possibly PTCLs在美国是
4、罕见的，并在亚洲，非洲和加勒比地区，可能更常见 due to exposure to specific viruses, such as the Epstein-Barr virus (EBV) and the human T-cell 由于暴露于特定的病毒，如的EB病毒（EBV）和人类T细胞， leukemia virus-1 (HTLV-1). 白血病病毒1型（HTLV - 1）。 PTCLs generally affect people older than 60 years, although they can occur anytime during adulthood. PTCL
5、s一般影响60岁以上的人，虽然他们可以随时发生在成年期。 Although the signs and symptoms of PTCLs vary according to the subtype, some common signs and 虽然PTCLs的迹象和症状不同亚型，一些常见的体征 symptoms of the diseases include fatigue, a painless swelling in the neck, armpit or groin (due to an 疾病的症状包括疲劳，在颈部，腋窝或腹股沟的无痛性肿大 （由于 enlarged lymph nod
6、e), night sweats, rash and weight loss. 扩大淋巴结），盗汗，皮疹和减肥。 New therapies are showing some effectiveness in treating patients who have certain subtypes of PTCL, 新疗法在治疗PTCL的某些亚型的患者一些成效 ， and other potential therapies are being studied in clinical trials. 和其他潜在疗法的临床试验正在研究。 However, standards of care have
7、 not 然而，护理标准 been established for newly diagnosed PTCL patients or for patients who have disease that has relapsed 已建立新诊断PTCL的患者或患者有疾病的人有复发的 (recurred) or is refractory (resistant to treatment). （复发）或难治性（耐治疗）。 More research and clinical trials focusing specifically on the various subtypes of PTCL ar
8、e needed to 更多的研究和临床试验，特别侧重于PTCL的各种亚型都需要 define the optimal management of patients who have these diseases. 定义有这些疾病的患者的最佳管理。 Introduction 简介 Peripheral T-cell lymphomas (PTCLs) are uncommon and aggressive non-Hodgkin lymphomas (NHLs) 外周T细胞淋巴瘤（PTCLs）是罕见的侵袭性非霍奇金淋巴瘤（NHLs） that develop in mature white b
9、lood cells called “T cells” and “natural killer (NK) cells.” NHL is the ，发展成熟的白 细胞称为“T细胞”和“自然杀伤（NK）细胞。”细胞NHL是 name for many different types of cancer that start in cells called “lymphocytes,” a type of white cell that 名称为许多不同类型的癌症，细胞开始被称为“淋巴细胞，白细胞类型 helps the body fight infection. 帮助人体抵抗感染。 There ar
10、e two main types of lymphocytes: B lymphocytes (B cells) and 主要有两种类型的细胞：B淋巴细胞（B细胞）和 T lymphocytes (T cells). T淋巴细胞（T细胞）。 NHL may arise in B cells or T cells. 国家冰球联赛中可能出现的B细胞或T细胞。 B-cell lymphomas are more common than B细胞淋巴瘤是较常见的比 T-cell lymphomas. T细胞淋巴瘤。 NHLs may be indolent (slow growing) or aggre
11、ssive (fast growing). NHLs可好逸恶劳（生长缓慢）或侵略（快速增长）。 Page 2 第2页 The Leukemia & Lymphoma Society 1311 Mamaroneck Avenue White Plains, NY 10605 白血病和淋巴瘤协会 1311马马罗内克大道白色平原，纽约10605 Information Specialist 800.955.4572 www.LLS.org 信息专家800.955.4572www.LLS.org Peripheral T-Cell Lymphoma Facts/2 外周T细胞淋巴瘤的事实/ 2 For
12、 additional information about NHL, please see the free Leukemia & Lymphoma Society (LLS) 有关国家冰球联赛的其他信息，请参阅免费的白血病和淋巴瘤协会（LLS ） booklets Non-Hodgkin Lymphoma and The Lymphoma Guide Information for Patients and 小册子 非霍奇金淋巴瘤和淋巴瘤指南-患者信息 Caregivers . 护理人员 。 This publication provides descriptions of the vari
13、ous subtypes of PTCL. 本刊物提供PTCL的各种亚型的描述 。 It also includes specific 这也包括具体的 information on the diagnosis, stages and treatment of PTCLs; new drugs being studied in clinical trials; 信息的诊断，分期和治疗PTCLs;在临床试验正在研究新的药物; and support resources. 和支持资源。 About Peripheral T-Cell Lymphoma 关于外周T细胞淋巴瘤 Between 10 pe
14、rcent and 15 percent of all patients with NHL have a T-cell lymphoma subtype. 非霍奇金淋巴瘤的所有患者的10和15之间的有T细胞淋巴瘤亚型。 PTCLs PTCLs generally affect people aged 60 years and older and are diagnosed slightly more often in men than in 一般影响年龄在60岁及以上的人略多往往比男性被确诊 women. 妇女。 However, younger adults and children are
15、 also diagnosed with PTCLs. 然而，年轻的成年人和儿童，也诊断PTCLs 。 PTCL is an uncommon PTCL的是一种罕见的 disease in the United States. 在美国疾病。 Some forms of PTCL are more common in Asia, Africa and the Caribbean, PTCL的一些形式较为常见，在亚洲，非洲和加勒比地区 ， possibly as a result of exposure to specific viruses, such as the Epstein-Barr v
16、irus (EBV) and the human 可能是由于暴露于特定的病毒，如爱泼斯坦-巴尔病毒（EBV）和人类的结果 T-cell leukemia virus-1 (HTLV-1). T细胞白血病病毒1型（HTLV - 1）。 The World Health Organization (WHO) classification system recognizes 13 different subtypes of PTCL 世界卫生组织（WHO）的分类系统承认的PTCL的13个不同的亚型 and has grouped the diseases into three categories: nodal, extranodal and leukemic. 分组分为三类疾病：淋巴结，结外病变和白血病。 WHO has al
