《静电纺丝：生物相容性纳米复合材料的制备与应用.doc》由会员分享，可在线阅读，更多相关《静电纺丝：生物相容性纳米复合材料的制备与应用.doc（5页珍藏版）》请在金锄头文库上搜索。
1、 静电纺丝论文：生物相容性纳米复合材料的制备与应用【中文摘要】21世纪,生物医用材料越来越成为世界各国的研究热点。生物相容性是生物医用材料区别于任何其他材料的最主要特征,是评价一种材料能否在生物医学领域应用的根本依据。本论文中,我们研究的对象为壳聚糖(Chitosan,CS)、聚乙烯吡咯烷酮(Polyvinylpyrrolidone,PVP)以及氢氧化钙,它们均具有良好的生物相容性。近年来,利用静电纺丝制备的纳米纤维及纳米纤维毡已经成为生物医学领域的研究热点。电纺纳米纤维及纤维毡具有的高性能和多功能性使得它们广泛应用于生物医学领域,例如组织工程、生物传感器、创敷材料、药物载体和酶的固定等方面。
2、PVP和CS都以具有良好的生物相容性而出名,特别地,CS具有抗菌能力,PVP具有止血作用。因此,本文中,我们运用静电纺丝技术制备了CS/PVP双功能纳米复合纤维,并使用扫描电镜、透射电镜、红外光谱仪、X射线衍射仪对其进行了表征,同时利用热分析仪研究了纳米复合纤维毡的热稳定性。通过对实验结果的分析,我们认为制备的CS/PVP双功能纳米复合纤维是一种优秀的生物医用材料,能广泛应用于创伤敷料、生物支架、组织工程等生物医学领域。另外,由于普通氢氧化钙类根管充填材料具有封闭性差、抑菌作用较弱等缺点。我们采用滴定沉淀法合成纳米氢氧化钙,为纳米氢氧化钙根管充填材料的制备提供良好的基础。【英文摘要】In th
3、e 21st century, the research of biomedical materials more and more becomes hot spots around the world. Biomedical materials are different from any other materials due to its biocompatibility, and the biocompatibility is the basis to evaluate whether a material in biomedical application. In this pape
4、r, Chitosan (CS), Polyvinylpyrrolidone (PVP) and calcium hydroxide all have excellent biocompatibility.Recently, the electrospun nanofibrous mats have become a very hot research topic in the area of biomedical materials. Above of all, electrospinning is a progressive and efficient method for manufac
5、turing high performance nan?obers and mats due to its versatility and potential for applications in diverse fields. The notable applications include in tissue engineering, biosensors, filtration, wound dressings, drug delivery, and enzyme immobilization. Both PVP and CS were well known for their bio
6、compatible and biodegradable properties, especially, CS has antibacterial property, PVP has hemostatic effect. In our present work, a series of CS/PVP dual-function blend nanofibers and mats were fabricated with different weight ratio of CS to PVP by electrospinning method. The diameter, morphology,
7、 structure, and properties of nanofibers and mats were investigated by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared (FT-IR). In addition, the thermal stability of mats was studied by differential scanning calorimetry
8、(DSC). According to these tests and relative discussions, the CS/PVP dual-function blend nanofibrous mats should be a kind of excellent biomedical materials, which would be used broadly in medical field, such as wound dressings, biomaterial scaffolds, and tissue engineering.In addition, the common c
9、alcium hydroxide root canal filling material of calcium hydroxide with poorly sealed bacteriostasis weaker shortcomings. The nanometer calcium hydroxide was synthesized by titration precipitation, which was good for the preparation of nanometer calcium hydroxide root canal filling material.【关键词】静电纺丝
10、 壳聚糖 聚乙烯吡咯烷酮 纳米纤维 根管充填材料【英文关键词】Electrospinning Chitosan Polyvinylpyrrolidone Nanofibers Root canal lling material【备注】索购全文在线加好友：1.3.9.9.3.8848 同时提供论文写作一对一指导和论文发表委托服务【目录】生物相容性纳米复合材料的制备与应用摘要4-5Abstract5第一章 前言8-231.1 纳米材料和纳米技术概述81.2 纳米复合材料8-101.2.1 纳米复合材料相关概念8-91.2.2 纳米复合材料的分类91.2.3 纳米复合材料的制备9-101.3 材料的
11、生物相容性10-131.3.1 生物相容性概念及分类101.3.2 生物材料的类型与应用10-121.3.3 纳米生物材料12-131.4 聚乙烯吡咯烷酮的应用13-141.4.1 聚乙烯吡咯烷酮的性质131.4.2 聚乙烯吡咯烷酮的应用13-141.5 壳聚糖概述14-171.5.1 壳聚糖的化学结构14-151.5.2 壳聚糖的物理化学性质151.5.3 壳聚糖的制备15-171.5.4 壳聚糖的应用171.6 静电纺丝技术17-191.6.1 静电纺丝简介17-181.6.2 静电纺丝的基本原理181.6.3 静电纺丝纤维的影响因素18-191.7 氢氧化钙在根管充填材料上的应用19-2
12、01.7.1 根管充填及根管充填材料191.7.2 氢氧化钙在根管充填材料上的应用19-201.8 本论文的创新之处20-21参考文献21-23第二章 CS/PVP双功能纳米复合纤维的制备与应用研究23-362.1 引言232.2 实验部分23-252.2.1 主要化学试剂23-242.2.2 实验仪器242.2.3 静电纺丝法制备CS/PVP纳米复合纤维242.2.4 样品测试与表征24-252.3 结果与讨论25-332.3.1 CS和PVP质量比对CS/PVP纳米复合纤维的影响25-272.3.2 纺丝液浓度对CS/PVP纳米复合纤维的影响27-292.3.3 红外光谱分析29-302.3.4 XRD30-322.3.5 热分析32-332.4 本章小结33-34参考文献34-36第三章 纳米氢氧化钙根管充填材料的研究36-413.1 引言363.2 实验部分36-373.2.1 实验试剂363.2.2 实验仪器36-373.2.3 滴定沉淀法合成纳米氢氧化钙373.3 结果与讨论37-393.3.1 红外光谱分析37-383.3.2 XRD分析383.3.3 透射电镜分析38-393.4 本章小结39-40参考文献40-41第四章 结论41-42致谢42-43硕士期间已（待）发表论文情况43
