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1、龙源期刊网 http:/中危急性肺栓塞患者溶栓治疗的安全性及有 效性 作者：米玉红 梁颖 陆艳辉 李雅敏刘文旭 王蒨 刘双 来源：中华急诊医学杂志2013年第 02期【摘要】目的通过前瞻性非随机的对照研究，探讨中危组急性肺栓塞患者接受溶栓治疗 的安全性及有效性。方法连续选择首都医科大学附属北京安贞医院急诊重症监护室2005年6 月至 2012年 5月期间明确诊断的中危组急性肺栓塞177例，其中接受溶栓治疗患者102例， 抗凝治疗75例，分别对其在接受治疗后2 h、24 h、7 d的临床症状、客观指标、肺动脉增强 CT及肺灌注通气结果进行评价，数据处理采用配对t检验和X检验进行统计学分析。结果
2、两组患者基础病比较差异无统计学意义(P0.05)，溶栓组出血6例(5.9%)，抗凝组1例(1.3%)(Pv 0.05)，均无致命性出血病例发生；溶栓组患者治疗2 h呼吸、心率、血压的 变化差异具有统计学意义(P【关键词】急性肺栓塞；中危组；溶栓治疗；抗凝治疗；安全性；有效性Safety and efficacy of the thrombolytic therapy in submissive pulmonary thromboembolism MI Yu-hong， LIANG Ying， LU Yan-hui， LI Ya-min， LIU Wen-xu， Wang Qian， LIU S
3、huang. Emergency Medicine Care Unit， Capital Medical University Affiliated Beijing Anzhen Hospital， Beijing 100029， ChinaCorresponding author： MI Yu-hong， Email：【Abstract】Objective To study prospectivelythe safety and efficacy of the thromblytic therapy in acute submassive pulmonary thromboembolism
4、(PTE) without randomized control. Methods A total of consecutive 177 patients with acute submassive PTE admitted to the emergency intensive care unit were screened from June of 2005 to May of 2012. After a comprehensive screening，102patients were treated with thrombolytic therapy (TT group)， and 75
5、with anticoagulation therapy ( AT group) . Clinical signs and physical examination findings were recorded 2 hours， 24 hours and 7 days after treatment. Echocardiography (ECG) was repeated 24 hours later. Lung perfusion scan and CT pulmonary artery ( CTPA) were repeated on the 7th day. All data was a
6、nalyzed by paired t test and Chi-square test. Results Bleeding happened in 6 patients of TT group and in 1 patient of AT group (P0.05)， and no lethal hemorrhage occurred in the two groups. There were no statistically significant differences in demographics and clinical history of patients between TT group and AT group (P0.05).There were statistically significant changes in respiratory rate, heart rate and systolic blood pressure in the TT group 2 hours after treatment and great changes in
