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1、顾中国学术期刊洌wwv/ 论文发表专家一上消化道出血论文：奥曲肽联合泮托拉唑治疗上消化道大出血疗效分析摘要目的 探讨奥曲肽联合泮托拉唑治疗上消化道大出血的疗效。方法 选择76例上消化道大出血病例，随机分两组，治疗组38例，对照组38例。治疗组采用除常规的抗休克、扩容、泮托拉唑抑酸、止血、输血、上氧、监测生 命体征，记24小时出入量，综合治疗外，先皮下注射奥曲肽O.lmg,继而用5%葡萄糖250ml加奥曲肽0.3mg,小剂量持 续静滴，24小时总量0.6mg，连续使用5-7天。对照组采用 常规的抗休克、扩容、泮托拉唑抑酸、止血、输血、上氧、监测生命体征，记24小时出入量，综合治疗。结果 治疗组:
2、 显效率65.8%，有效率31.6%，无效为2.6%，总有效率：97.4%, 有效病例于1-3天后开始进流质饮食，生命体征平稳，精神 状态逐渐好转。对照组：显效率52.6%，有效率23.7%，无效为23.7%，总有效率：76.3 %结论 在消化道大出血使用 奥曲肽联合泮托拉唑治疗疗效显著，两药联合应用，可产生 协同作用，从而使出血得到迅速控制，值得临床推广使用。关键词奥曲肽；泮托拉唑；上消化道出血the analysis on the application of octreotide with pantoprazole in hemorrhage of upper digestive tra
3、ctyang hui 论文发表专家一(the second affiliated hospital of guiyang medicalcollege, kaili city, guizhou province 556000)abstract objective to evaluate the effect ofoctreotide with pantoprazole to hemorrhage of upperdigestive tract.methodto select 76 cases of hemorrhage of upper digestive tract,and divide t
4、hem into twogroups randomly with 38 patients in experimental group and 38 patients in control group. in addition to theregular use of anti-shock,expansion,pantoprazoleacidsuppression,stanching,blood transfusion, the oxygen, monitoring vital signs, 24-hour intake and outputrecord for comprehensive tr
5、eatment,the treatment group are firstly given the subcutaneous injection ofoctreotide 0.1mg,then added with 250ml of 5% glucose andoctreotide 0.3mg for low dose continuous infusion,0.6mg of total 24 hours, and 5 to 7 days of continuous use. the control group are given the regular use the anti-shock,
6、 expansion, pantoprazole acid suppression,stanching,blood transfusion, the oxygen,monitoring vital signs, 24-hour intake and output record for comprehensive treatment. resultthe 论文发表专家一significant efficiency of the treatment group was 65.8%, efficiency 31.6%, inefficiency was 2.6%, the total effecti
7、ve rate is 97.4%.the effective cases start into the liquid diet after 1 to 3 days with stable vitalsigns,and mental state gradually improved. the significant efficiency of the control group was 52.6%, efficiency 23.7%, inefficiency was 23.7%, and the total effective rate is 76.3%. conclusionthe effe
8、ct of octreotide with pantoprazole to hemorrhage of upper digestive trac is significant,the combination of two drugs can produce synergy,so that the rapid control of bleeding.its worthy of widely clinical use.keywords octreotide; pantoprazole; hemorrhageof upper digestive tract上消化道出血系指屈氏韧带以上的消化道出血，是消化 内科常见病，且大多病情危重，若不积极治疗，其病死率达 20%左右，60岁以上患者上消化道出血病死率高于青年人， 占30% 50%因此，积极早期止血治疗具有重要意义1。奥曲肽为人工合成 8肽，是天然生长抑素的衍生物，具有天 然生长抑素的生物活性。我院从 2005年9月以来采用沈阳 东宇药业有限公司生产的注射用奥曲肽粉针，国药准字
