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1、Separ a tion of a cet o n i trile-eth y l ac e tate byextr a cti v ed istillation w i th mix e d solven tLi Chunlil, Zong Lili2 and Fang Ji ngS cho o l of Chemi cal E n gineering, Hebei Univ e rsity of T echnolo g y, Tia nj in, 3 00 1 3E mail： li ch unl i _hebut12 6 .com, Tel: + 86Abs t ractComputer
2、-aided m ol ecu la r d es i gn (CAMD) approach was br in g i n this work for s elec t ing extra c ti v e so l vents. The s e p a r a t ion of a ce to n i tri le-ethyl ac e tate Az e otr o pic syst em was c a rried out throug h a batch extr active dis ti llation pro cesses with N,N- d imet h y l form
3、 a m i de(DMF), glycol (EG) and DMF-EG m i x ture as solvents separate ly . T he e ffec ts o f d iffe r ent o p erating cond itio ns we re studied , solvents , r ati o o f mixe d s ol ve nt, solve nt flow ra te an d reflux ratio were al l inc lud ed . It w as fou nd tha t the mixed solve nt DMF-EG s
4、 h ow e d better sepa r a tion ef f e c t t han t h e single solvent. The best proportion of the mixed solvent was 3:7 ( the quali ty of DMF a nd EG ); w hen the solvent flow rate and reflux ra tio in creas ed, th e s epa r ation e ffect of mixe d so lv ent improv ed； u nd er the con di tions that s
5、ol v ent flow rate wa s 20 mL / min, reflux r ati o was 2, quali ty fr a c tio n of eth yl acetate i n the t op produc t could reach 99.62KeywordsSeparation; Batch extractive distill ation; Mixed solvents； Acetonit rile； Et hy l acetat e1.IntroductionAcetonitr il e an d et hyl acetate are wi dely us
6、ed i n ch emic al an d phar mac eutica l in dust ri es as chemical raw materials a nd goo d or ga nic solv ent 1. But t he two form a zeotro pe, e thyl acetat e h old 77% an d th e o ther 2 3 is acet onitr ile(mass frac ti on), common distillation met ho d can not make any effect. Therefore, some co
7、mpanies have to treat them as waste, this not only cause seriously waste of resources and economy, bu t a lso pollute th e enviro nment. At p resent, Di Jia ndo ng2of Tia nji n universi ty has realized the s ep ar at ion of ace tonit rileethyl a cetate b y hetero g eneous bat ch a z eot r op ic d i
8、sti ll atio n, but the prod u ct rec eived in t his wa y h ave l ower purit y, but h igh ene rgy c onsump tion. According to the difference of solubil ity that acetonitril e and et hyl a cet a te i n the wat er, Ma W e n c h a n 3 ad opts the m e thod of l i q uid-liqu i d ext rac ti ve which us e w
9、 ater a s e xtra ct ive agent to sep arate aceto ni tril ee t hyl a ce tat e ,the product of et h yl ac etate can a c h ie v e 9 8.5%, but acetonitrile m ix ed with abundant water, s o recovery o f acetonitrile i s ve ry difficult. Accor di ng to our knowledge, no authors have st u died t he separ a
10、 tio n of acet o nitr i le - ethyl a cetate by ext r acti ve distillati on. In rec e nt ye a rs, the application of extracti v e distill a t ion 4-6for the separa tion of c los eb o iling m i x tu re h as been wide ly accepte d and commerci a l i zed over the co nv e n t i o n al di sti l lation whi
11、c h may al s o b e fe a s i ble b ut w i th s u bsta nt ia l column i nvestment. H o wever, due to th e p ro blem o f s e l ectiv i t y and so l u b il i ty are often i n con s isten t in singl e so lve nt , li mit i ts a ppl ication an d dev elop ment . Mi xe d s olvent s guara nt ee high sele ctiv
12、i ty , a nd imp roved sol ubili ty at the sa me time through the combination of main solvent and vice solvent7. In recent years, mixed solvents are applied more and more in extractive dist illati on8-11.This paper is devoted t o the s tudy of the s eparat ion of the mixture acetonitrile- ethyl acet
13、a te by using ext r act i ve batch d is ti lla tion w hich ext ra ctive sol ve n t is mixed s ol ve nts. F irst, the s e lec tion of an ade q uate extractive solvent i s present ed based on the comput er aided mol ecular design of solvents for separation processes combini ng group contribut ion meth
14、ods with graph princi ple. Later , re sults of severa l lab or at or y ba t ch test s are presented servi ng for determination of the most effective solvent. Fi nall y, t he main operating parameters of extractive di st illation p rocess w ere optimize d.2. En t raine r selec t ion for t he separat
15、i on of ace t onitri le- ethyl acetate mixtureThe extract ive di sti llatio n is g enerally a pp li ed to the s eparati on of clos eb oil ing mi xt ures, whi ch by convent io na l dist il lation is di fficult to separa te. Th e de si gn and op timiza ti on of extrac t ive di stilla tion is mo re co
16、mp lex than th at of the c onventi ona l distil lation w hen cons id erin g the s electio n of sui table solven t to enhance t h e s ep ar ation. In the extracti v e di still a ti o n, t he se l ecti o n o f a su i table solvent is f un dame ntal to ensure an effe ct ive a nd econo mical d e sig n. Cur rently, the solvent selecti on can b e effecti vely hand led b y the as s istan ce of th e comp ut er- a ided mo le cular d es ign (CAMD) a
