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1、.Choice QuestionsType A 1 .The half-life of a drug is 2 hours, how much is the K? A. 0.1 (h-1) B. 0.2 (h-1) C. 0.3 (h-1) D. 0.35 (h-1) E. 2 (h-1) 2. Which of the following statements about first-order kinetics elimination is true? A. The elimination rate is fast B. The elimination rate is slow C. Th
2、ere is no relationship between the amount of drug in the body and elimination rate D. The elimination of drug is in direct proportion to the blood concentration of the drug E. The elimination of drug is in inverse ratio to the amount of drug in the body 3. As far as some drug is concerned, which of
3、the following statements concerning the drugs combination with plasma protein is true? A. The higher the binding rate, the stronger the curative effect B. The lower the binding rate, the stronger the curative effect C. The higher the binding rate, the faster the excretion D. There is not relationshi
4、p between binding rate and curative effect E. All of the above are incorrect 4. Which of the following administrations can immediately reach the plateau concentration? A. Decreasing dose, increasing times of administration B. Decreasing administering interval C. Increasing administering interval D.
5、Administration of loading dose E. Frequent administration by iv5 .In general, the weak acid drugs in basic solution are A. weakly ionized, pass across the biomembrane easily B. strongly ionized, pass across the biomembrane easily C. strongly ionized, pass across the biomembrane hardly D. weakly ioni
6、zed, pass across the biomembrane hardly E. all of above are incorrect 6. If the stomach juice pH is1. 4 and plasma pH is 7.4, how much is the drug concentration ratio of plasma to stomach juice for a weak acidic drug with pKa 5.4 when the distribution reach to equilibrium？ A.50 B.100 C.1000 D.10000
7、E.0.1 7. All of the following statements are applicable to the sublingual route of administration EXCEPT A. plasma concentration decreased by first pass elimination B. lipid soluble drugs will be absorbed rapidly C. Irritant drugs should not be given by this route D. blood flow through the mucosa is
8、 high E. taste of drugs limits the usefulness of this route 8. Which of the following can be advisable to treat hemorrhage of digestive tract? A. Norepinephrine oral administration B. Norepinephrine iv administration C. Norepinephrine im administration D. Norepinephrine subcutaneous injection E. Adrenaline oral administration 9. Phentolamine can most likely be used to treat A. peripheral arterial spasm B. angina pectoris C. arrhythmia
