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1、骨肽联合葡萄糖酸钙治疗骨质疏松症的临床观察目的 探讨骨肽联合葡萄糖酸钙治疗骨质疏松症的临床效果。 方法 选择 2013年 111月本院收治的 120 例骨质疏松症患者为研究对象，随机分为观察组 和治疗组各 60 例，对照组患者给予非甾体消炎镇痛药物和钙剂口服，同时给予 补充维生素D。观察组患者在对照组治疗基础上给予骨肽(50 mg) +250 ml 0.9%NaCl 注射液以及葡萄糖酸钙( 10%，20 ml) +250 ml 5%葡萄糖注射液静脉 滴注，治疗2个月后观察比较两组患者的骨痛改善情况、腰椎和左侧股骨颈骨密 度的变化情况。 结果 观察组患者治疗总有效率( 90.00%)明显高于对照
2、组(56.67%),差异有统计学意义(PV0.05)；观察组治疗后腰椎L24骨密度水平 为(0.780.10) g/cm2，左侧股骨颈骨密度水平为(0.580.02) g/cm2，均明显 高于对照组，差异有统计学意义(PV0.05)；两组不良反应发生率差异无统计学 意义(P0.05)。结论骨肽联合葡萄糖酸钙治疗骨质疏松症效果较好，能有效 改善骨痛，提高骨密度，值得临床推广应用。Abstract Objective To investigate the clinical effect of bone peptide joint calcium gluconate in the treatment
3、 of osteoporosis.Methods 120 cases of patients with osteoporosis in our hospital from January to November 2013 were divided into control group (60 cases) and observation group (60 cases),the control group were treated by non-steroidal anti-inflammatory drugs,oral calcium and vitamin D supplements;th
4、e observation group were treated by ossotide (50 mg) + 250 ml 0.9% NaCl and calcium gluconate injection (10%,20 ml) + 250 ml 5% glucose intravenous injection on the basis of control group.The improvement of bone pain,lumbar spine and left femoral neck bone mineral density changes in circumstances of
5、 two groups were analyzed.Results The total effective rate of the observation group (90.00%) was significantly higher than that of the control group (56.67%),the difference was significnat (PV0.05).Bone mineral density of the lumbar spine L2-4 levels was (0.780.10) g/cm2 and the left femoral neck bo
6、ne mineral density levels was (0.580.02) g/cm2 of the observation group,which was significantly higher than that of the control group respectively,the difference was significnat (PV0.05).Adverse reaction rate of the two groups had no significant difference (P 0.05).Conclusion The efficacy of bone pe
7、ptide joint calcium gluconate treating osteoporosis is well,it can effectively improve bone pain and increase bone mineral density,is worth using in clinic.Key words Bone peptide;Calcium gluconate;Osteoporosis骨質疏松症是一种以骨微结构破坏、骨量低下、骨脆性提高、易发骨折为主 要特征的全身性骨量减少的疾病1，主要临床表现为腰背疼痛、骨折、畸形等。 骨质疏松的主要临床诱因包括遗传因素、内分泌因素、营养因素、药物或疾病因 素等，这些诱因影响高峰骨量，导致骨量丢失严重而表现为骨质疏松 2。临床 对于骨质疏松症的主要治疗手段是药物治疗，常用的治疗药物包括钙剂、维生素
