川崎病(英文)

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1、川崎病(英文) Diagnosis Treatment and Long-Term Management of Kawasaki Disease A Statement for Health Professionals From the Committee on Rheumatic Fever Endocarditis and Kawasaki Disease Council on Cardiovascular Disease in the Young American Heart Association Jane W Newburger Masato Takahashi Michael A

2、Gerber Michael H Gewitz Lloyd Y Tani Jane C Burns Stanford T Shulman Ann F Bolger Patricia Ferrieri Robert S Baltimore Walter R Wilson Larry M Baddour Matthew E Levison Thomas J Pallasch Donald A Falace and Kathryn A Taubert Pediatrics 20041141708-1733 DOI 101542peds2004-2182 This information is cur

3、rent as of November 5 2005 The online version of this article along with updated information and services is located on the World Wide Web at comcgicontentfull11461708 PEDIATRICS is the official journal of the American Academy of Pediatrics A monthly publication it has been published continuously si

4、nce 1948 PEDIATRICS is owned published and trademarked by the American Academy of Pediatrics 141 Northwest Point Boulevard Elk Grove Village Illinois 60007 Copyright 2004 by the American Academy of Pediatrics All rights reserved Print ISSN 0031-4005 Online ISSN 1098-4275 Downloaded from com by on No

5、vember 5 2005 AMERICAN ACADEMY OF PEDIATRICS AMERICAN HEART ASSOCIATION ENDORSED CLINICAL REPORT Guidance for the Clinician in Rendering Pediatric Care Jane W Newburger MD MPH Masato Takahashi MD Michael A Gerber MD Michael H Gewitz MD Lloyd Y Tani MD Jane C Burns MD Stanford T Shulman MD Ann F Bolg

6、er MD Patricia Ferrieri MD Robert S Baltimore MD Walter R Wilson MD Larry M Baddour MD Matthew E Levison MD Thomas J Pallasch DDS Donald A Falace DMD and Kathryn A Taubert PhD Diagnosis Treatment and Long-Term Management of Kawasaki Disease A Statement for Health Professionals From the Committee on

7、Rheumatic Fever Endocarditis and Kawasaki Disease Council on Cardiovascular Disease in the Young American Heart Association ABSTRACT Background Kawasaki disease is an must be made by physicians in light of the particular acute self-limited vasculitis of childhood that is charac- conditions presented

8、 by individual patients Pediatrics terized by fever bilateral nonexudative conjunctivitis 200411417081733 AHA Scientific Statements vasculitis erythema of the lips and oral mucosa changes in the therapy aneurysm diagnosis extremities rash and cervical lymphadenopathy Coro- nary artery aneurysms or e

9、ctasia develop in 15 to 25 of untreated children and may lead to ischemic heart ABBREVIATIONS MI myocardial infarction CI confidence disease or sudden death interval Ig immunoglobulin TNF- tumor necrosis actor- 2D Methods and Results A multidisciplinary committee 2-dimensional 2DE 2-dimensional echo

10、cardiography IVIG intra- of experts was convened to revise the American Heart venous immunoglobulin ESR erythrocyte sedimentation rate CRP C-reactive protein LV left ventricular RCA right coronary Association recommendations for diagnosis treatment artery LAD left anterior descending coronary artery

11、 LMCA left and long-term management of Kawasaki disease The main coronary artery LCX left circumflex coronary artery IVUS writing group proposes a new algorithm to aid clinicians intravascular ultrasound MRA magnetic resonance angiography in deciding which children with fever for 5 days and CT compu

12、ted tomography MRI magnetic resonance imaging IL 4 classic criteria should undergo electrocardiography interleukin INR international normalized ratio tPA tissue plas- receive intravenous gamma globulin IVIG treatment or minogen activator ECG electrocardiogram both for Kawasaki disease The writing gr

13、oup reviews the available data regarding the initial treatment for chil- dren with acute Kawasaki disease as well for those who awasaki disease is an acute self-limited vas- have persistent or recrudescent fever despite initial ther- culitis of unknown etiology that occurs pre- apy with IVIG including IVIG retreatment and treat- Kd

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