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1、Biochemistry Course OutlinePreface Biochemistry and molecular biology focus on the chemical composition of organism and the laws of chemical changes during the life process. The content of the course includes the following: structure and function of some biomacromolecules as protein, nucleic acid, c
2、arbohydrate, lipid and enzyme. metabolism of carbohydrate, lipid, amino acid and nucleotide in vivo. molecular basis and regulation laws in genetic information transferring.cell signal transduction and extracellular matrix needful for various physiological activities. special biochemistry of some ti
3、ssues and organs as blood and liver. This subject mainly adopts principle and methods of chemistry, and also melts the theory and skills of biophysics, physiology, cell biology, genetics and immunology. So, it has extensive interrelation and intersection with numerous subjects. Biochemistry and mole
4、cular biology is one of the important basic subjects for medicine.Chapter 1 IntroductionContent of courseI. The concept of biochemistry. The development history of biochemistry II. Main contents of biochemistry coursei. The chemical constitutes, molecule structure and function of organismii. The mat
5、erial metabolism and its regulationiii. The reserve, deliver and expression of genetic informationIII. Biochemistry and medical scienceRequestI. Grasp the concept of biochemistryII. Acquaint with the main contents of biochemistryIII. Know the relation between the biochemistry and medical scienceChap
6、ter 2Structure and function of proteinContent of courseI. Importance of protein in life processII. Molecule constitute of proteini. Chemical element of the proteinii. Basic structure unit of proteinamino acidsiii. Peptide iv. Protein classificationIII. Molecular structure of proteini. Primary struct
7、ure ii. Secondary structureiii. Tertiary structure iv. Quaternary structure IV. Relationship between the structure and function of proteini. Relationship of primary structure and function of proteinii. Relationship of spatial structure and function of proteinV. Physics and chemistry property, separa
8、tion and purification of proteini. Physics and chemistry propertyii. Separation and purificationiii. Amino acids sequence analysis of polypeptide chainiv. Spatial structure measurement of protein RequestI. Know the characteristics of chemical element of protein, grasp the basic structure of amino ac
9、ids and acquaint with the classification and the physics and chemistry property of amino acids.II. Grasp the basic concept of the peptide bond and peptide chain and the primary structure characteristics of insulin. Know a few important bioactive peptide.III. Know the principles of protein classifica
10、tion.IV. Grasp the familiar type of secondary structure: alpha-helix, beta-pleated sheet, beta-turn and random coil. Acquaint with the concept of the peptide unit, motif, and chaperon.V. Grasp the concept of tertiary structure and domain. Analyze the tertiary structure characteristics of ribonucleas
11、e. VI. Grasp the concept of quaternary structure and analyze the quaternary structure characteristics of hemoglobin ( Hb).VII. Grasp the relationship between primary structure and function of protein .Acquaint with the concept of molecular disease.VIII. Grasp the relationship between spatial structu
12、re and function of protein and acquaint with relationship between the conformation variety and the function of binding to oxygen of hemoglobin.IX. Grasp the ampholyte property, high molecular weight and denaturation of protein. Acquaint with precipitation and of protein ultraviolet absorption.X. Gra
13、sp the electrophoresis and gel filtration of protein. Know the salt precipitation, isoelectric point, ultrafiltration and ultracentrifugation.XI. Know the principles of primary structure measurement of protein.XII. Know the principle and meaning of the spatial structure estimation of protein.Chapter
14、 3 Structure and function of nucleic acidContent of courseI. Chemical constitute of nucleic acid i. Base component of nucleotide ii. Pentose and nucleoside iii. Structure and naming of nucleotide II. Primary structure of nucleic acidIII. Spatial structure and function of deoxyribonucleic acid(DNA) i
15、. Secondary structure of DNAdouble helix structure modelii. Superhelix of DNAiii. Function of DNAIV. Spatial structure and function of ribonucleic acid(RNA)i. Messenger ribonucleic acid (mRNA) ii. Transfer ribonucleic acid (tRNA)iii. Ribosomal ribonucleic acid (rRNA)iv. Other small ribonucleic acid and RNomicsv. Ribozyme V. Physics and chemistry property of nucleic acid and its application i. General physics and chemistry propertyii. DNA denaturation iii. DNA renaturation (annealing) and hybridizationVI. Nuclease RequestI. Grasp the structure, symbol and property of familiar nucleotid
