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1、免疫组化在肺小细胞癌活检诊断中的重要性目的通过肺穿刺及支气管镜获得的组织极易因挤压过甚而结构不清，使肺 小细胞癌与低分化鳞癌、淋巴瘤间会出现形态学上的重叠，我们通过免疫组化探 讨肺小细胞癌活检标本的诊断及鉴别诊断。方法收集肺穿刺及支气管镜活检病 例46例，病理组织形态学均诊断为肺癌，倾向于肺小细胞癌，每个病例均进行 CgA、Syn、Sclc、TTF-1、ki67、CK5/6、P63、3邛E12、LCA 免疫组化诊断。结 果46例诊断为肺癌，倾向于肺小细胞癌的活检标本经免疫组化证实：43例为肺 小细胞癌、2例低分化鳞癌、1例非何杰金氏淋巴瘤。结论 免疫组化在肺小细 胞癌的诊断与鉴别诊断中具有十分
2、重要的意义。Abstract Objective To explore the diagnosis and differential diagnosis of biopsy specimens of small cell lung carcinoma via immunohistochemistry，considering the tissues acquired via pneumocentesis and bronchoscope are easily to be squeezed so much so that their structures become unclear， which
3、 lead to morphological overlaps between small cell lung carcinoma， poorly differentiated squamous carcinoma and lymphoma. Methods 46 patients who were received biopsy of pneumocentesis and bronchoscope were selected and were diagnosed of lung cancer both pathologically and morphologically.The diagno
4、sed cancer tended to be small cell lung carcinoma.Each patients were received immunohistochemistry of CgA，Syn，Sclc， TTF-1， ki67，CK5/7， P63，34pE12 and LCA. Results Among the 46 patients diagnosed of lung cancer，biopsy specimens which tended to be small cell lung carcinoma were confirmed by immunohist
5、ochemistry：43 patients were infected bysmall cell lung carcinoma，2 lower differentiated squamous carcinoma and 1 non-Hodgkins lymphoma. Conclusion Immunohistochemistry is of great significance in the diagnosis and differential diagnosis of small cell lung carcinoma.Key words Small cell lung carcinom
6、a ； Bronchoscopic biopsy ； Immunohistochemistry肺癌是当今世界范围内最常见的恶性肿瘤之一。其中，肺小细胞癌(small cell lung carcinoma，SCLC)占其15%20%1，是肺癌中恶性程度最高的肿瘤。经 临床实践证实，SCLC对放化疗敏感性比非小细胞癌高，手术不是其治疗的首选 方案，因此治疗前的准确诊断是十分关键的。目前，肺穿刺及支气管镜活检是诊 断肺肿瘤的主要手段。但是，由于它取材标本数量有限和易造成取材组织挤压的 原因，单从组织形态上诊断SCLC是存在一定风险，本研究旨在探讨相关蛋白在 其诊断及鉴别诊断中的表达特点，来反映免疫组化在SCLC活检诊断中的重要 性。1资料与方法1.1 一般资料
