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1、1 Analysis of the perceptions and attitudes to participate in radical and palliative clinical2trials among Chineselymphoma and head/neck cancerpatients34Qiu-Huan Kong1,2* MD, Lu-Ping Yang1,2* MD, Yue-Rong Lai2,3 MD, Hui-Ying Qin2,4 MD,5 Lian-Zhu He2,5 MD, Yu-Shan Liu 1,2 MD, Yan-Er Li 2,5 MD, Xiu-Ji
2、n Chen 2,5 MD, Miao-Zhen6 Qiu1,2? MD, PhD, Zi-Xian Wang 1,2?,? MD, Yu Wang 1,2*,?,?MD, PhD7 1. Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou8 510060, China9 2. Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China;10 Collaborative Inn
3、ovation Center for Cancer Medicine, Guangzhou 510060, China113. Department ofGynecological Oncology, Sun Yat-Sen UniversityCancer Center,12 Guangzhou 510060, China13 4. Department of Nursing, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China14 5. Department of Clinical Research, Sun Yat-
4、Sen University Cancer Center, Guangzhou15 510060, China16 * Qiu-Huan Kong, Lu-Ping Yang, and Yu Wang contributed equally to this work.17 ? Joint senior authors.18 ? Corresponding to:19Yu Wang, Department of Medical Oncology, Sun Yat-Sen University Cancer Center, 65111234567Dong Fend Road East, Guang
5、zhou 510060, China; Tel and Fax: +86-20-87343765; E-mail:Zi-Xian Wang, Department of Medical Oncology, Sun Yat-Sen University Cancer Center,651 Dong Fend Road East, Guangzhou 510060, China; Tel and Fax: +86-20-87343795 ;E-mail: 21 Abstract2 Objective: The purpose of this prospective study was to inv
6、estigate the perceptions and3 attitudes to participate in radical and palliative clinical trials among Chinese lymphoma and4 head/neck cancer patients.5 Patients and Method: A self-developed questionnaire was administered to hospitalized6 patients in the Department of Medical Oncology in Sun Yat-Sen
7、 University Cancer Center7 between 20 September 2014 and 20 September 2015. This study included lymphoma patients8who were enrolled into a radical treatment clinical trial, and head/neck cancer patients9 participating in a palliative clinical trial.10 Results: There were 136 lymphoma patients and 87
8、 head/neck cancer patients who11 completed and returned the questionnaire. The questionnaire return rate was 100%. More12 than 90% of the patients in both groups showed trust and acceptance for medical care13personnel, and more than 50% of the patients in both groups were in hope of trying new14 med
9、ication, receiving free medication, and receiving new treatment at an earlier rate. As15 compared with those in the radical trials, patients in the palliative clinical trials were more16 likely to hope to try new medication ( P0.001) and receive a new treatment at an earlier date17 (P=0.025), but le
10、ss likely to hope to receive free medication P=0(.047).18 Conclusions: This study reveals several shared perceptions and needs of patients in both the19 radical (lymphoma) and palliative (head/neck cancer)settings and explores thedifferences in312345patientsattitudes between radical clinical trials
11、and palliative clinical trials. These findingsmay provide a basis for improving recruitment of patients for different types of clinical trialsand ensuring that patients have a better understanding of clinical trials.Keywords: radical clinical trials; palliative clinical trials; differences in percep
12、tion; newtreatment; free medication; patient recruiting6741 Introduction2 Clinical trials refer to any investigation in human subjects intended to discover or verify the3clinical,pharmacologicaland/orotherpharmacodynamic effectsofoneormore4 investigational medicinal product(s), and/or to identify an
13、y adverse reactions to one or more5 investigational medicinal product(s) and/or to study absorption, distribution, metabolism and6 excretion of one or more investigational medicinal product(s) with the object of ascertaining7its (their) safety and/or efficacy. 1 Historical data reveals that 2% of all foreign cancer8 patients participate in clinical trials,2 and in spit
