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1、基因本体论(Gene Ontology)概览Designed by Morrain报告：孔垂亮 导师：高琳 日期：10/09/27为什么要建立Gene Ontology帶解决生物学定义混乱的现象，使各种数据库中基 因产物功能描述相一致稼使得在不同生物数据库中的查询具有极高的一致 性帶允许在各种水平查询基因产物的特性Gene Ontology widely adoptedFlyBasegBaseSGDfairMGRAMENEAnnotatlo晋 TIGRHNSWEfOlGzOCFESThe Wcllcortie Trust f Sanger Institute .,w */ C7VCXM： AG
2、SKTATKTX SZOCA KXdEACKW n reso urcePJSMOGO(gene ontology)是:基因本体联合会(Gene Onotology Consortium) 所建立的数据库,旨在建立一套适用于各种物种 的,对基因和蛋白质功能进行限定和描述的,并能随着硏究不断深入而更新的语义(terms)词汇标 准。GO语义的分类廉分子功能(Molecular Function) 描述在个体分子生物学上的活性,如催化 活性或结合活性。谆生物学过程o/og/cm/ Process) 由分子功能有序地组成的,具有多个步骤 的一个过程。傑细胞组件(Ce/t/前Component)Insu
3、lin间期m期中期后期末期了细脱指基因产物位于何种细胞器或基因产物组 制如糙面内质网,核糖体,蛋白酶体 即基因产物在什么地方起作用Ocellulaicompo nemmolecular functionbiological_process严旧i pigmentationregulation of biological processpigment metabolic processduring pigmentationIpigmentation during developmentnegative regulation of biological processnegative regulat
4、ion of pigmentation during developmentpositive regulation of pigmentation during developmentpigment metabolic process during developmental pigmentationpositive regulation of biological processregulation oT pigmentation during developmenteye pigment precursortransportinegative regulation of cuticlepi
5、gmentationnegative regulation of eyepigmentationpositive regulation of cuticlepigmentationpositive regulation of eyepigmentation#语义信息id: G0:0043473 name: pigmentationnamespace: biological_process def: “The deposition or aggregation of coloringmatter in an organism, tissue or cell.n GOC:krc synonym:N
6、one is a: G0:0008150# all: all nHEB田E)田BBB田E0:biological adhesion 4754 gene products;biological regulation 63973 gene products:carbohydrate utilization (4 gene products:carbon utilization 172 gene products:cell killing 840 gene products:cell proliferation 4733 gene products:cellular component orgamz
7、anon or biogenesis 32633 gene products:multicellular organismal process 34760 gene products:negative regulation of biological process 12350 gene products :nitrogen unlization 221 gene products johosDhofAjti|izatiQraenjroductsIss 13868 gene productsE 田BBB447301 gene products ElG0:0008150 : biological
8、_process 343853 gene products E.D G0：0022610D G0；0065007 GO：OOD9758D G0；0015976O GO：00D1906n G0;0008283O GO：007184DG0;0009987 : cellular process 189386 gene productsG0:0016265 : death 7121 gene productsG0:0032502 : developmental process 28592 gene productsG0:0051234 : establishment of localization 4
9、0590 gene productsG0:0040007 : growth 6815 gene productsG0:0002376 : immune system process 6300 gene productsG0:0051179 : localization 45074 gene productsG0:0040011 : locomotion 6853 gene productsG0：0008i52 : metabolic process 179341 gene productsG0:0051704 : multi-organism process 11122 gene produc
10、tsGO：0032S01G0；0048519GO：001974DGO;Q006794 D G0：0043473 : pigmentanon 408 gene products 0 G0：0050789 : regulation of biological process (57813 gene products n G0;0000003 : reproduction 12476 gene productsD GO：0022414 : reproductive process 9968 gene products n G0:0050896 : response to stimulus 37015
11、 gene products n GO:0048511 : rhythmic process 926 gene products n G0:0023052 : signaling 31044 gene produc n G0:0023046 : signaling process 19031 gene products n G0:0007587 : sugar utilization 13 gene products n G0:0006791 : sulfur udlizauon 14 gene products n GO:0016032 : viral reproduction 2761 g
12、ene products G0:0005575 : cellular_component 305208 gene products G0：0003674 : molecularfuncOon 366536 gene products语义之间的关系韶 is as part of语义关系之间的推导* is a is a is amiiochondrionAis a intracellular organelleorganelle#* part of part of - part of#语义关系之间的推导 part of is a part of 与is a part of part ofmiuxh
13、orxk 讪 membranepart of錢粒体 pan of胞内细腕器錢粒体砲内细腕器细胞pArX0f#w由参与合作的数据库来完成的,它们使用GO的定 义方法,对它们所包含的基因产物进行注释傑注释需要反映在正常情况下此基因产物的功能, 生物过程,定位等傑注释必须提供支持这种基因产物和GO术语之间联 系的证据#AmiGOhttpM/amigp.geneQiitQlogy.c 一羔m - .the Gene OntologyAmiGOSearchBrowseBLASTMore TodsHeipSearch The Gecc Oncosogy (Urabase| 仃 GO terms | 宀 genes or process 厂 exact matchthe Gene OntologyAmiGOTree Browser Filter tree view 83SettlersRerrM 31 Mien.# Q GO：OWS575B H G0:0003674Acbcns.Last acton; Reset the tree Graphcal Slew POTvairrfc Dowrioad.CBDRDFJCML GrapzdctE) a: ai (M6
