附录ATheColdChainanditsLogistics1. Authors:Dr.Jean-PaulRodriguezandDr.TheoNotteboomOverviewWhileGlobalizationhasmadetherelativedistaneebetweenregionsoftheworldmuchsmaller,thephysicalseparationofthesesameregionsisstillaveryimportantreality.Thegreaterthephysicalseparation,themorelikelyfreightcanbedamagedinoneofthecomplextransportoperationsinvoIved.Somegoodscanbedamagedbyshockswhileotherscanbedamagedbyunduetemperaturevariations.Forarangeofgoodslabeledasperishables,particularlyfood,theirqualitydegradeswithtimesincetheymaintainchemicalreactionswhichratecanbemostlymitigatedwithlowertemperatures.Ittakestimeandcoordinationtoefficientlymoveashipmentandeverydelaycanhavenegativeconsequences,notablyifthiscargoisperishable.Toensurethatcargodoesnotbecomedamagedorcompromisedthroughoutthisprocess,businessesinthepharmaceutical,medicalandfoodindustriesareincreasinglyrelyingonthecoldchaintechnology.Thecoldchainreferstothetransportationoftemperaturesensitiveproductsalongasupplychainthroughthermalandrefrigeratedpackagingmethodsandthelogisticalplanningtoprotecttheintegrityoftheseshipments.SpecializationhasledmanycompaniestonotonlyrelyonmajorshippingserviceproviderssuchastheUnitedParcelService(UPS)andFEDEX,butalsomorefocusedindustryspecialiststhathavedevelopedanichelogisticalexpertisearoundtheshippingoftemperaturesensitiveproducts.Thepotentialtounderstandlocalrules,customsandenvironmentalconditionsaswellasanestimationofthelengthandtimeofadistributionroutemakethemanimportantfactoringlobaltrade.Asaresult,thelogisticsindustryisexperiencingagrowinglevelofspecializationandsegmentationofcoldchainshippinginseveralpotentialnichemarketswithinglobalcommoditychains.Wholenewsegmentsofthedistributionindustryhavebeenveryactiveintakingadvantageofthedualdevelopmentofthespatialextensionofsupplychainssupportedbyglobalizationandthesignificantvarietyofgoodsincirculation.Fromaneconomicdevelopmentperspective,thecoldchainenablesmanydevelopingcountriestotakepartintheglobalperishableproductsmarket.Fromageographicalperspective,thecoldchainhasthefollowingimpacts:* Global.Specializationofagriculturalfunctionspermittingthetransportoftemperaturesensitivefoodproductstodistantmarkets.Enablesthedistributionofvaccinesandotherpharmaceuticalorbiologicalproducts.* Regional.Cansupportthespecializationoffunctionsandeconomiesofscale,suchasspecializedlaboratories.* Local.Timelydistributiontothefinalconsumer,namelygrocerystoresandrestaurants.2. EmergeneeofColdChainLogisticsWhileglobalcommoditychainsarefairlymodernexpansionsinthetransportationindustrytherefrigeratedmovementoftemperaturesensitivegoodsisapracticethatdatesbackto1797whenBritishfishermenusednaturalicetopreservetheirfishstockpiles.Thisproceswasalsoseeninthelate1800sforthemovementoffoodfromruralareastourbanconsumptionmarkets,namelydairyproducts.Coldstoragewasalsoakeycomponentoffoodtradebetweencolonialpowersandtheircolonies.Forexample,inthelate1870sandearly1880s,FrancewasstartingtoreceivelargeshipmentsoffrozenmeatandmuttoncarcassesfromSouthAmerica,whileGreatBritainimportedfrozenbeeffromAustraliaandporkandothermeatfromNewZealand.By1910,600,000tonsoffrozenmeatwasbeingbroughtintoGreatBritainalone.Thefirstreefershipforthebananatradewasintroducedin1903bytheUnitedFoodCompanyThisenabledthebananatomovefromanexoticfruitthathadasmallmarketbecauseitarrivedinmarketstooripe,tooneoftheworld'smostconsumedfruit.Thetemperaturecontrolledmovementofpharmaceuticalsandmedicalsuppliesisamuchmoremoderntransitoptionthantheshippingofrefrigeratedorfrozenfood.Sincethe1950s,logisticalthirdpartycompaniesbegantoemergeandinstitutenewmethodsforsuccessfullytransportingtheseglobalcommodities.Beforetheiremergenee,coldchainprocessesweremostlymanagedinhousebythemanufacturer.IntheUnitedStates,FoodandDrugAdministrationrestrictionsandaccountabilitymeasuresoverthestabilityofthecoldchainincitedmanyofthesecompaniestorelyonspecialtycouriersratherthancompletelyoverhaulingtheirsupplychainfacilities.Aspecializedindustrywasthusborn.Thevalueofthecoldchaininthepreservationofexpensivevaccinesandmedicalsupplieswasonlybeginningtoberecognizedwhentheselogisticalprovidersstartedtoappear.Asawarenessbegantogrow,sodidtheneedforefficientmanagementofthecoldchain.Therelianceonthecoldchaincontinuestogainimportanee.Withinthepharmaceuticalindustryforinstance,thetesting,productionandmovementofdrugsreliesheavilyoncontrolledanduncompromisedtransferofshipments.Alargeportionofthepharmaceuticalproductsthatmovealongthecoldchainareintheexperimentordevelopmentalphase.Clinicalresearchandtrialsisamajorpartoftheindustrythatcostsmillionsofdollars,butonethatalsoexperiencesafailurerateofaround80%.AccordingtotheHealthcareDistributionManagementAssociation,ofthecloseto200billiondollarsinpharmaceuticaldistribution,about10%aredrugsthataretemperaturesensitive.Thismakesthecoldchainresponsiblefortransportinganear20billiondollarinvestment.Iftheseshipmentsshouldexperienceanyunanticipatedexposuretovarianttemperaturelevels,theyruntheriskofbecomingineffectiveorevenharmfultopatients.T。