LOCUSPIGPR39ABP 658 bp mRNA linear MAM 07-NOV-2001DEFINITIONSus scrofa antibacterial protein precursor (PR-39) mRNA, complete cds.ACCESSIONL23825VERSIONKEYWORDSL23825.1 GI:435100SOURCESus scrofa (pig)ORGANISMSus scrofaEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; Sus.REFERENCE1 (bases 1 to 658)AUTHORSStorici,P. and Zanetti,M.TITLEA cDNA derived from pig bone marrow cells predicts a sequence identical to the intestinal antibacterial peptide PR-39JOURNALPUBMEDBiochem. Biophys. Res. Commun. 196 (3), 1058-1065 (1993)8250863REFERENCE2 (bases 1 to 658)AUTHORSStorici,P. and Zanetti,M.TITLEDirect SubmissionJOURNALSubmitted (16-DEC-1993) Natl. Lab. C.I.B., Area Science Park, Padriciano 99, 34012 Trieste, ItalyREMARKDirect SubmissionFEATURESLocation/Qualifierssource1..658/organism="Sus scrofa"/mol_type="mRNA"/db xref="taxon:9823"/tissue_type="bone marrow"gene1..>658/gene="PR-39"5'UTR1..17/gene="PR-39"CDS18..536/gene="PR-39"/note="preproprotein; cathelicidin"/codon_start=1/product="antibacterial protein precursor"/protein id="AAA31109.1"/db_xref="GI:435101"/translation="METQRASLCLGRWSLWLLLLALVVPSASAQALSYREAVLRAVDRLNEQSSEANLYRLLELDQPPKADEDPGTPKPVSFTVKETVCPRPTRQPPELCDFKENG RVKQCVGTVTLNPSIHSLDISCNEIQSVRRRPRPPYLPRPRPPPFFPPRLPPRIPPGF PPRFPPRFPGKR"sig_peptidemat_peptide3'UTRPolyA signa,l18..104/gene="PR-39"105..524/gene="PR-39"/product="pro-sequence homologous to pig cathelin (cathepsin L inhibitor); pro PR-39"534..>658/gene="PR-39"640..645/gene="PR-39"ORIGIN1 gggctcacct gggcaccatg gagacccaga gggccagcct gtgcctgggg cgctggtcac61 tgtggcttct gctgctggca ctcgtggtgc cctcggccag cgcccaggcc ctcagctaca 121 gggaggccgt gcttcgtgct gtggatcgcc tcaacgagca gtcctcggaa gctaatctct 181 accgcctcct ggagctggac cagccgccca aggccgacga ggacccgggc accccgaaac 241 ctgtgagctt cacggtgaag gagactgtgt gtcccaggcc gacccggcag cccccggagc 301 tgtgtgactt caaggagaat gggcgagtga agcagtgtgt ggggacagtc accttgaacc 361 catccattca ctcactggac atctcctgta atgagattca gagtgtcagg agacgtcccc 421 gacccccata tttgccaagg ccaaggccac ctccgttttt cccaccaagg ctcccaccaa 481 ggatcccacc agggttccca ccaaggttcc caccacggtt ccccggaaaa cggtgatgga 541 gtggctgata acatacccat taaaagcttt tggtgaatcc tgagcccagg gaaagtccta 601 ggatcttatt gttgtggctc agacttctga accatgaaaa ataaattctt gtgaaacg//LOCUS DEFINITION ACCESSION VERSION KEYWORDS SOURCEORGANISMREFERENCEAUTHORSTITLEJOURNALPUBMEDREMARKREFERENCEAUTHORSTITLEJOURNALPUBMED REFERENCE AUTHORSTITLEJOURNALPUBMED REFERENCE AUTHORS TITLEJOURNALPUBMED REFERENCE AUTHORSTITLENM_214450 659 bp mRNA linear MAM 03-SEP-2009 Sus scrofa peptide antibiotic PR39 (PR39), mRNA.NM_214450NM_214450.1 GI:47523953Sus scrofa (pig)Sus scrofaEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;Sus.1 (bases 1 to 659)Sang,Y. and Blecha,F.Porcine host defense peptides: expanding repertoire and functionsDev. Comp. Immunol. 33 (3), 334-343 (2009)18579204GeneRIF: stimulates cardiac growth and angiogenesis; attenuates myocardial ischemia-reperfusion injury;anti-apoptotic;anti-inflammatory; suppresses cancer cell growth and metastasisReview article2 (bases 1 to 659)Gao,Y., Lecker,S., Post,M.J., Hietaranta,A.J., Li,J., Volk,R., Li,M., Sato,K., Saluja,A.K., Steer,M.L., Goldberg,A.L. and Simons,M.Inhibition of ubiquitin-proteasome pathway-mediated I kappa B alpha degradation by a naturally occurring antibacterial peptideJ. Clin. Invest. 106 (3), 439-448 (2000)109304473 (bases 1 to 659)Yerle,M., Lahbib-Mansais,Y., Pinton,P., Robic,A., Goureau,A., Milan,D. and Gellin,J.The cytogenetic map of the domestic pigMamm. Genome 8 (8), 592-607 (1997)92508694 (bases 1 to 659)Zhao,C., Ganz,T. and Lehrer,R.I.Structures of genes for two cathelin-associated antimicrobial peptides: prophenin-2 and PR-39FEBS Lett. 376 (3), 130-134 (1995)74985265 (bases 1 to 659)Gudmundsson,G.H., Magnusson,K.P., Chowdhary,B.P., Johansson,M., Andersson,L. and Boman,H.G.Structure of the gene for porcine peptide antibiotic PR-39, acathelin gene family member: comparative mapping of the locus for the human peptide antibiotic FALL-39JOURNALProc. Natl. Acad. Sci. U.S.A. 92 (15), 7085-7089 (1995)PUBMED7624374REFERENCE6 (bases 1 to 659)AUTHORSShi,J., Ross,C.R., Chengappa,M.M. and Blecha,F.TITLEIdentification of a proline-arginine-rich antibacterial peptide from neutrophils that is analogous to PR-39, an antibacterial peptide from the small intestineJOURNALPUBMEDJ. Leukoc. Biol. 56 (6), 807-811 (1994)7996056REFERENCE7 (bases 1 to 659)AUTHORSStorici,P. and Zanetti,M.TITLEA cDNA derived from pig bone marrow cells predicts a sequence identical to the intestinal antibacterial peptide。