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1、Metastatic Breast cancer,Case Report,General information,Name: WU ChunHong Age: 40y Sex: Female Date of admission: February 9th,2011 Date of discharge: April 23th,2011,Chief complaint,She got hypoesthesia of lower limbs and inability to walk for more than a month,History of present illness,The patie
2、nt felt pain on the back by no obvious incentives in June 2010 The pain was tingling, especially in night-time The patient took orally traditional Chinese medicine , but had not tangible effects,Past, Personal & Family History,No hepatitis, hypertension, or diabetes No smoking, alcohol or drug abuse
3、 No inherited diseases No history of drug allergy Normal menstruation,Clinical findings,The left breast presented with diffused erythema and edema , induration about size of 3.0cm*3.0cm,Ultrasound examination,a 3 cm left breast mass and a normal right breast,Thoracic MRI examination,Thoracic MRI exa
4、mination,High-density mass was shown on the seventh thoracic, and bone destruction also had been found.,Enhanced MRI,Laboratory examination,2011-02-09 1.Hepatic functions ALT 40 U/L AST 20 U/L TB Normal 3.Tumor markers CA19-9 Normal,2. Blood routine test Hb 82 g/L RBC 4.541012 /L WBC 6.1109 /L PLT 2
5、01 109 / L,puncture biopsy,She received ultrasound guided breast core needle puncture biopsy Puncture tissue pathology :The left breast invasive ductal carcinoma,Primary diagnosis,Breast cancer with bone metastasis,Treatment,On February 11, 2011 in orthopedic department, The Patient received “the se
6、venth thoracic tumor resection and pedicle screw fixation“,Histological examination,Seventh thoracic tumors was identified as metastatic carcinoma, and the immunohistochemistry results showed the possibility of breast cancer bone metastasis was very large,IMMUNOHISTOCHEMICAL results,ER+ PR+ CerbB2-
7、CK20- EMA+,Ckpan+,CK5/6-,Treatment,The patient recovered well , and then transferred into our department Chemotherapy two times before operation: February 23 ,2011 March 20 ,2011 The chemotherapy plan was TEC,Treatment,After the chemotherapy The lesions area of left breast showed no reduction,Treatm
8、ent,Modified radical mastectomy on march 31,2011,Bilateral oophorectomy On the same day,Histological examination,The left breast invasive ductal carcinoma The basal resection margin of tumor was close to the surrounding normal tissue The axillary lymph nodes metastasis (13/15),Immunohistochemical,ER+ PR+ CerbB2- E-cad+,Ki6750%+,P53+,Ck5/6-,Treatment,After operation, the patient continued to receive chemotherapy and radiotherapy.,Thank you,
