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1、英文论文投稿信Coverletter模板qiusuo BY - 2006-1-17 8:59:00Dear Editor,We would like to submit the enclosed manuscript entitled GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons, which we wish to be considered for publication in Nature Neuroscience. GD
2、NF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerated in Parkinsons disease. In this paper, we report an unexpected, acute effect of GDNF on A-type potassium channels, leading to a potentiation of neuronal excitability, i
3、n the dopaminergic neurons in culture as well as in adult brain slices. Further, we show that GDNF regulates the K+ channels through a mechanism that involves activation of MAP kinase. Thus, this study has revealed, for the first time, an acute modulation of ion channels by GDNF. Our findings challe
4、nge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is to regulate neuronal excitability, and consequently dopamine release. These results may also have implications in the treatment of Parkinsons disease. Due to
5、 a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ., and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I am Sincerely yours,case2Dear Editor,We would like to submit the enclosed manuscript entitled Ca2+-binding protein freq
6、uenin mediates GDNF-induced potentiation of Ca2+ channels and transmitter release, which we wish to be considered for publication in Neuron. We believe that two aspects of this manuscript will make it interesting to general readers of Neuron. First, we report that GDNF has a long-term regulatory eff
7、ect on neurotransmitter release at the neuromuscular synapses. This provides the first physiological evidence for a role of this new family of neurotrophic factors in functional synaptic transmission. Second, we show that the GDNF effect is mediated by enhancing the expression of the Ca2+-binding pr
8、otein frequenin. Further, GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity, leading to an enhancement of Ca2+ influx. Thus, this study has identified, for the first time, a molecular target that mediates the long-term, synaptic action of a neurotrophic factor. O
9、ur findings may also have general implications in the cell biology of neurotransmitter release.0630投稿写作某杂志给出的标准Sample Cover Letterthe example used is the IJEBCase 3Sample Cover Letterthe example used is the IJEB Dear Editor of the please type in journal title or acronym: Enclosed is a paper, entitle
10、d Mobile Agents for Network Management. Please accept it as a candidate for publication in the journal title. Below are our responses to your submission requirements. 1. Title and the central theme of the article. Paper title: Mobile Agents for Network Management. This study reviews the concepts of
11、mobile agents and distributed network management system. It proposes a mobile agent-based implementation framework and creates a prototype system to demonstrate the superior performance of a mobile agent-based network over the conventional client-server architecture in a large network environment.2.
12、 Which subject/theme of the Journal the material fits New enabling technologies (if no matching subject/theme, enter Subject highly related to subject of journal but not listed by please type in journal title or acronym) 3. Why the material is important in its field and why the material should be pu
13、blished in please type in journal title or acronym? The necessity of having an effective computer network is rapidly growing alongside the implementation of information technology. Finding an appropriate network management system has become increasingly important todays distributed environment. Howe
14、ver, the conventional centralized architecture, which routinely requests the status information of local units by the central server, is not sufficient to manage the growing requests. Recently, a new framework that uses mobile agent technology to assist the distributed management has emerged. The mo
15、bile agent reduces network traffic, distributes management tasks, and improves operational performance. Given todays bandwidth demand over the Internet, it is important for the journal title/acronym readers to understand this technology and its benefits. This study gives a real-life example of how t
16、o use mobile agents for distributed network management. It is the first in the literature that reports the analysis of network performance based on an operational prototype of mobile agent-based distributed network. We strongly believe the contribution of this study warrants its publication in the journal title/acronym.4. Names, addresses, and email addresses of fou
