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1、 分类号： R743密级：公开学 号：113066学位类型：专业学位硕 士 学 位 论 文银杏达莫注射液治疗缺血性中风后轻度认知功能障碍的临床疗效观察研究生：何华梅导 师：李培春 教授所属学院：瑞康临床医学院专 业：中西医结合临床研究方向：脑血管病中西医结合防治研究完成日期： 2014年5月10日广西南宁 原创性声明本人郑重声明：本人所呈交的学位论文，是在导师的指导下独立进行研究所取得的成果。学位论文中凡引用他人已经发表或未发表的成果、数据、观点等，均已明确注明出处。除文中已经注明引用的内容外，不包含任何其他个人或集体已经发表或撰写过的科研成果。对本文的研究成果做出重要贡献的个人和集体，均已在
2、文中以明确方式标明。本声明的法律责任由本人承担。论文作者签名：日期：关于学位论文使用授权的声明本人完全了解广西中医药大学有关保留使用学位论文的规定，同意学校保留并向国家有关部门机构送交论文的复印件和电子版，允许论文被查阅和借阅。本人授权广西中医药大学可以将学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或扫描等复制手段保存、汇编学位论文。（保密论文在解密后遵守此规定）论文作者签名：导师签名：日期：日期： 银杏达莫注射液治疗缺血性中风后轻度认知功能障碍的临床疗效观察中文摘要目的：观察银杏达莫注射液对缺血性中风后轻度认知功能障碍的临床疗效。方法：选择2012年12月至2013年1
3、2月入住广西中医药大学附属瑞康医院神经内科的符合缺血性中风后轻度认知功能障碍诊断的患者80例作为受试者，随机分为治疗组和对照组，比例为1:1，每组各40例，治疗组给予银杏达莫注射液20ml兑入5葡萄糖溶液或0.9%氯化钠溶液250ml中静滴，每日1次，共用14天；对照组给予0.9%氯化钠注射液250ml 静滴，每日1次，共用14天。治疗过程中两组病例均给予西医基础治疗包括卧床休息、保持安静、低流量吸氧；均给予脑细胞代谢药物治疗；维持水与电解质平衡、酸碱平衡以及一般支持疗法；血压过高者给予对症降压治疗。治疗期间不联合任何有关疗效不确切或者尚待明确的治疗痴呆药物。分别采用MMSE量表及MoCA量表
4、对治疗组和对照组在治疗前、治疗后进行认知评测，观察MMSE得分变化，同时观察MoCA量表总分变化，分析数据。结果：（1）MMSE方面：对照组与治疗组在治疗前、后MMSE的组内比较，结果均：P0.01，差异有统计学意义，说明单纯用西医基础治疗缺血性中风后轻度认知功能障碍有一定的疗效；治疗组在治疗前、治疗后MMSE的组内比较，结果：P0.01，差异有统计学意义，说明运用银杏达莫注射液联合西医基础治疗本病亦能改善认知功能症状；治疗 后，治疗组与对照组MMSE评分的组间比较，结果：P0.05，差异有统计学意义，说明治疗组的疗效优于对照组。（2）MoCA方面：对照组在治疗前、治疗后MoCA的组内比较，结
5、果：P0.01，差异有统计学意义，说明单纯用西医基础治疗缺血性中风后轻度认知功能障碍有一定的疗效；治疗组在治疗前、治疗后MoCA的组内比较，结果：P0.01，差异有统计学意义，说明运用银杏达莫注射液联合西医基础治疗本病亦能改善认知功能症状；治疗后，治疗组与对照组MoCA评分的组间比较，结果：P0.05，差异有统计学意义，说明治疗组的疗效优于对照组；（3）治疗后总疗效：治疗组与对照组总有效率分别为87.5%、67.5%，两组差异具有显著性。结论：银杏达莫注射液合并西药治疗缺血性中风后轻度认知功能障碍疗效明显优于对照组，疗效安全、确切，值得临床推广。关键词：缺血性中风后轻度认知功能障碍，MMSE，
6、MoCA,银杏达莫注射液 Clinical observation Yinxingdamo injection treatment of ischemic stroke with mild cognitive impairment ABSTRACT Objective: Clinical efficacy Yinxingdamo Injection treatment ofischemic stroke with mild cognitive impairment.Methods: We choose 80 cases patients from December 2012 toDecembe
7、r 2013 in RuiKang Hospital, after ischemic stroke in line with mildcognitive impairment diagnosed as subjects were randomly divided into atreatment group and control group, the ratio is 1:1, 40 cases in each group,the treatment group received Yinxingdamo injection 20ml blended with 5%glucose solutio
8、n or 0.9% sodium chloride solution infusion 250ml, Once aday, sharing 14 days. The control group received 0.9% sodium chlorideinjection 250ml infusion, Once a day, sharing 14 days. Two groups of patientsduring treatment were given basic treatment includes bed rest Medicine, keepquiet, low-flow oxyge
9、n ; Also Were given brain cell metabolism drug therapy,maintain water and electrolyte balance, acid-base balance and generalsupportive therapy;High blood pressure were given symptomaticantihypertensive therapy. Without any joint during treatment efficacy are notplausible or pending definitive treatm
10、ent of dementia drugs. Scale were usedMMSE and MoCA scale of the treatment group and the control group beforetreatment, after treatment, cognitive evaluation, observed changes in MMSEscore, while observing the MoCA total score changes, analyze the data.Results: (1) MMSE aspects:Two groups (control g
11、roup, treatmentgroup) before and after treatment within the group MMSE, the resultsstrongly suggest that: P 0.01, the difference was statistically significant, indicating that Western medicine alone basis or with on this basis plusYinxingdamo injection after the liquid treatment of ischemic stroke w
12、ith mildcognitive impairment can improve the symptoms of cognitive function; aftertreatment between treatment groups and the control group MMSE scorescompared the results: P0.05, the difference was statistically significant,indicating that the treatment efficacy group than the control group.Aftertre
13、atment, the treatment group and the control group between MMSE scoregroup compared the results: P0.05, the difference was statisticallysignificant, indicating that the efficacy of the treatment group than the controlgroup; (2)MoCA aspects:two groups (control group, treatment group)before treatment,
14、after comparing the group MoCA, the results stronglysuggest that: P 0.01, the difference was statistically significant, indicatingthat simply using Western-based or based on this plus Yinxingdamo afterinjection in the treatment of ischemic stroke with mild cognitive impairmentcan improve the symptoms of cognitive function;After treatment, thetreatment group and the control group between MoCA score group comparedthe results: P 0.05, the difference was statistically significant, Descriptionefficacy in the treatment group than t
