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1、D rug Standards o f China 2010, V ol111 N o15S0S2010M115335 V1 不同溶剂的对照品和样品溶液的滴眼用利福平含量|070607 0709121k4HW/m inc/%RSD/%nc/%RSD/%nvY110 / 0. 7 5 / 0. 7 5 A0 15. 8 32. 5 5 30. 7 3. 9 520 25. 3 31. 240 31. 6 32. 760 36. 4 33. 280 40. 6 33. 6420 / / / 50. 4 0. 9 4440 51. 11 280 53. 6 / 2 51. 41 300 53. 3
2、51. 2 Y 0 90. 9 0. 6 4 87. 0 / 220 91. 1 85. 840 90. 5 /60 90. 0vA0 15. 6 37. 5 5 17. 0 32. 4 520 27. 9 26. 240 36. 0 32. 960 42. 9 38. 580 48. 0 42. 61 020 / / 2 64. 5 / 21 040 / 64. 4*c9(vYAvAckA!ZE,YvB9A,vA?3,Pc,TpbPc,A)M,cT9vbVHW,Ar,ct,9?NHcbA)Z,A?HW=(?q),0arb312 v(YH,Ec(90%,NLc,&c?,Ab313 ,3H%8A
3、s7,Li,PH,BHW=Pby7ckA!ZE:vY,BA,Yd,c5PMb314 A,!AbypSc/:vA8!ZEA!,SVebID 1 SE015S06 2000M1= S . 2000:3061Te:,o,50=bS#Z_:0_#0sb: 13576686219bHPLCEH_00F11许江红,张若良, 宋晓园(8gJ0_,341000 )K1: 建立中药降糖药中加入 11种化学降糖物质 (阿卡波糖a盐酸二甲双胍a盐酸苯乙双胍a甲苯磺丁脲a格列吡嗪a格列齐特a格列本脲a格列美脲a格列喹酮a盐酸吡格列酮a瑞格列奈)的HPLC检测方法bZE: C18 ( 416 mm 200 mm, 5
4、Lm ) ,流动相为乙腈-01 05 mo l# L- 1醋酸铵溶液(用冰醋酸调 pH值至 410) ( 60B40),流速为 11 0 mL# m in- 1, 检测波长 235 nmbT: 本法快速a准确a灵敏b: 可用于中药降糖药加入上述 11种化学物质的检测b1oM: 中药降糖药;化学降糖物质; H PLCms|: R 927 DSM: A cI|: 1009- 3656( 2010) - 5- 335- 6TheDetermination of11ChemicalAntidiabeticMaterial inAntidiabeticsofChineseTrad-itionalMedi
5、cinebyHPLCXu Jiang-hong, Zhang Ruo-liang, Song X iao-yuan (G anzhou Institute for F ood and Drug C ontrol, Ganzhou 341000 )S0S2010M115336 D rug Standards o f China 2010, V ol111 N o15Abstract: A n H PLC m ethod w as established for the determ ination o f 11 chem ica l antid iabe tic m ate rial ( A c
6、arbose, M e tform in hydro-chlor ide, Phenform in hydroch lor ide, to lbutam ide, g lip izide, G liclazide, G lyburide, G lim ep iride, G liqu idone, P iog litazone hydro chlo-ride, R epag lin ide) in An tidiabetic of chinese traditiona lm edicine1 Method: C18 ( 41 6 mm 200 mm, 5 Lm ), aceton itrile
7、 and 0105m ol# L - 1 amm on ium ace tate( 60B40) ( adjusted to pH 41 0 w ith ace tic ac id) as the mob ile phase, the flow rate w as 11 0 mL# m in- 1,and detec ted atw aveleng th o f 235nm1Results: The m ethod is fast, accurate, sensitive1Cnclusion: It can be used for determ ination o f 11chem ica l
8、 antidiabetic m ate rial in A ntidiabetics o f Chinese T rad itiona lM ed ic ine1KeyWords: Chem ica lA ntid iabetesic M ater ia;l P reparations o f Ch inese T rad itiona lM ed icine; HPLC0Ys:0a00b0rB,r9,b70ry,TMvb000$,s,+0TMary,Y0),7OA,-gsvhnB0b04,9T,00s4(,4V,H7V,V.b5y1V|B007ChfF0fb0rdEFESv&8rB/vb,y
9、_dEFy_ZEEsA1,3y00F5oa=Ja&YaJ&aa+aaaSaa111_ZE,0S5ua)E4/b1 Nk0BP211D0?; Ag ilen t1200rAMN; 420A9;5ov(|100808-200501);=Jv(|100664-200401 );v(|100281-200602);+v(|100269-200603);v(|100135-200404);v(|100674-200301);Sv(|100280-200301 );v(|100634-200401 );1v(|100753-200501),v(1_;&YaJ&lik0,kk*u=_0;J?aYB;k4sBb2 ZET211 色谱条件与系统适用性试验EAoAA4;Y-0105 m ol# L- 1ZA
