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1、口国国SepSIs生物标志物一一景新进展大连医科大学附属第一医院重症医学科张久之enesoayneancmsccoeonoiesppecounmeneeiutsSepsisbiomarkers:areviewChaamposeratoseantousVncentAbstnctInvoduqiontBomatencanbevnefulrldenuiingorningoutepstldongiyngpotenswhomeybenettfompeolichenpesorasesingheeponseeheapyMethodsWeuesdansechonicsofihePubWeddouboseeng
2、heteywodisepas“andbomateriokeralycinialndegpenmenalsudieswhideuatedbomsterinepdsNesulesTeseorcheneved3i70efeercescovenng178dfeventborsteConduslonsManybomansnsieleananotdclioejacepisMosqfbebamaderiidbeeneseddnicitypimaty芸pejnesttnidopsnjIelivyeiieeensedgdoiostloneaeufidentspealoyorienstyestsutreyspos
3、didncaleETongcsneIeenmoswiddyuedbureveneseaveImtedabWgyIdetngushsepsfomfhernfemmeioocondionsorpedctcucome2010年文献综述:目前进行研究和尝试的Sepsis生物标志物共有178种,其中18种仅经过动物实验性研究,58种经过动物实验性和临床试验研究,101种仅经过临床试验研究。研究证实178种生物标记物中34种有利于Sepsis的诊断,但是其中仅有5种生物标记物的特异性和敏感性超过90%细胞因子越化因子类Sepsis生物标志物ebls1Cniokinekhemokinebiomaheride
4、nttiedineerotureseorchIvihsomesalecdeterencedenSoean。EnEComencE37E7samnnxsctyaeurte1Y5/neeeeseoveenanenondnenaneeeces5史口dnepeoenerayysnioohoeneen4enveompedmorenepeeEE5/cnenesemy口团ce/Er72205220IL8(poimg以220pg/ml为临界值对感染性休克患儿进行分组,两组悦者28d病死率具有显著性差异(P200pgmi|。代4|一+ppyayxieWoapy“Rse2Contngnebtpangveetimgi
5、petL822I016520Rpatyepmdeen00rguiepeiavxeis0eVioratdoymeuiyolLgaiotCiopgmywanaqpiedionidutond119PaierglAiedomanbepeiykdocdnte09IL8saoopgml|4酒|一人pupccureetpypeaeiettLi0pomlndaneniesatuLiLR4ifeiu一20pgymgepetiniyNustacinttnn一Z0PgmsnNd88brdoyneraiywanpfledinidiionixtiwisanidorel1IneratCJd5gynyreotowPOate
6、agepM以220pg/mil方临弃值,评价儿科想染词件克患者28d病死率的特异性和敏感性虽然不高(64%、78%),但IL-8=220pg/ml对28d病死率的阴性预测值达95%。进一步研究是示IL-8对病死率的阴性预测值受年龄影响较大,对考年患者预测价值较低OKGINALARnicLETheDiagnosticValueofC-reactiveProtein,Interleukin-8,andMonocyteChemotacticProteininRiskStratificationofFebrileNeutropenicChildrenWithHematologicMalignancie
7、sShercenMolanedEL-Maghraphs41D,ManiarMdofamedUoneerMUDJUanarAoamedfamailM1D,LobmaUShalabsM4D,andadir4hmiedEL-MalalnUD(RediotrNionaolOncol200729:131-130对于中性粒细施凑少仲发浑的悟韵,IL-5、MiCF-1、CFKP可监刺感染性发持非感染性发热,明确感染组的患者IL-8、MCP-1、CRP明显升高,具有显著性差异(P0.001)。IL-8、MCP-1、CRP的特异性、敏感性、阴性和阳性预测值分别为(71%、77%、54%、88%),(64%、92
8、%、53%、95%8),(70%、73%、51%、85%)。几种生物标志物联合对诊断的价值更大LweuJsusassDDollosowouzesonsoeyEarlySerumProcalcitonin,Interleukin-6,and24-HourLactateClearance:UsefulIndicatorsofSepticInfectionsinSeverelyTraumatizedPatientsAdrianWiletratthissTerinaBarlardtfert-LadvlevMea.ReieSeorker.AnKeel回顾性分析近10年内创伤严重程度评分(1ISS)大于16分的外科创伤患者1032例,评价患者出现感染性井发症与PCT、IL-6、24h乳酸清除率、CRP等的关系BSoonLeininonapoieneD口吊心心E心E目5口一吊。E。玑1许eD1cmposesersmoonidtecenaeiiinsncerocanop人gn仪nnnlcn0ecpdoeree000ILateienppep00LsnEcnpopnsnnenicuntnekldnCcepoeaviue创伤患者非感染和感染感者比较,IL-6和CRP水平差异有显著性(P0.05或P0.01)。IL-6在早期(入院7d内)差异更明显;CRP在入院后迅速升高,但在入院72h以后差异更明昱
