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1、SciFinder 药物研发的必备工具,Dr. Qiong Yuan SciFinder产品拓展经理 CAS用户会 2010年11月3-5日,January 15, 2019,2,CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.,议程,SciFinder产品开发 案例研究 即将添加的新功能 其它信息 Q&A,January 15, 2019,3,CAS is a division of the American Ch
2、emical Society. Copyright 2010 American Chemical Society. All rights reserved.,SciFinder是科学研究的首选工具,有基于Web的直观界面 支持常用英语表达-如， “I am interested in the milk production of cows” 建立了绘画结构式的工具 检索所有主要的CAS数据库 被世界上所有主要的化学和制药公司使用,January 15, 2019,4,CAS is a division of the American Chemical Society. Copyright 20
3、10 American Chemical Society. All rights reserved.,SciFinder最初的开发团队,January 15, 2019,5,CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.,现在的SciFinder开发团队,January 15, 2019,6,CAS is a division of the American Chemical Society. Copyright
4、2010 American Chemical Society. All rights reserved.,根据用户的使用经验进行产品改进是非常重要的,内容,January 15, 2019,7,CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.,创建数据库的科学家们,January 15, 2019,8,CAS is a division of the American Chemical Society. Copyri
5、ght 2010 American Chemical Society. All rights reserved.,CAS分析全球化学信息，其中亚洲一些重要出版物也包含在内,每年, CAS涵盖 10,000 种期刊和世界上61个授权机构的专利 2,068 种亚洲期刊 所有主要亚洲授权机构的专利，包括 中华人民共和国 韩国 日本 印度,January 15, 2019,9,CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.
6、,9,世界范围内新的化学专利持续增长.,Year,CAS Patents Covered Each Year,January 15, 2019,10,CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.,.包括中文化学研究专利,Chemistry Patent Applications Published 1999-2009,0,10000,20000,30000,40000,50000,60000,70000,8000
7、0,1999,2000,2001,2002,2003,2004,2005,2006,2007,2008,2009,2010,Year,Documents in CAS Databases,China (SIPO),Japan (JPO),United States (USPTO),Projected, based on January-June 2010,January 15, 2019,11,CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rig
8、hts reserved.,SciFinder 是唯一一个支持企业全程研发需求的研究工具,Pre-clinical “Discovery”,Target Discovery,Lead Discovery,Lead Optimization,ADMET,disease models target identification target validation,assay development screening drug design,medicinal chemistry rational drug design structure activity relationships,pharm
9、acokinetics bioavailability systemic exposure,January 15, 2019,12,CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.,我们来检索关于老年痴呆症的最新研究,January 15, 2019,13,CAS is a division of the American Chemical Society. Copyright 2010 American Chemi
10、cal Society. All rights reserved.,从感兴趣的主结构检索开始,January 15, 2019,14,CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.,SciFinder给出了CAS登记号338747-41-4的界面，并显示其有12篇文献,January 15, 2019,15,CAS is a division of the American Chemical Society. Co
11、pyright 2010 American Chemical Society. All rights reserved.,其中还包括了3篇专利,January 15, 2019,16,CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.,亚结构检索得到了55个结果,January 15, 2019,17,CAS is a division of the American Chemical Society. Copyrig
12、ht 2010 American Chemical Society. All rights reserved.,点击Get Reference后，其显示有14篇是与生物研究相关的结果，其中包含了6篇专利,X,January 15, 2019,18,CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.,我们仔细查看第二篇专利中的详细内容,January 15, 2019,19,CAS is a division of th
13、e American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.,进行Markush检索以进一步探究专利保护范围,January 15, 2019,20,CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.,SciFinder有许多检索这个先导化合物合成方法的强大功能,January 15, 2019,21,CAS is a division of the American Chemical Society. Copyright 2010 American Chemical Society. All rights reserved.,Get Similar Reactions为相同化学变化提供了可供选择的合成路径,January 15, 2019,22,CAS is a division of the American Chemical So
