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1、细胞增殖、分化、凋亡异常与疾病AbnormalCellProliferation,DifferentiationApoptosisandRelatedofDisease“二坂细胞增殖异常与疾病AbnormalCellProliferationandDiseases一、细胞周期及其调控*细胞周期概念(ConceptandphasesofCellcycle)【CellProliferation】细胞分裂和再生的过程,纹胞涛过分栗进行增殓,把遗传信息传给子代,保持物种的延续和数量增多。细胞增殖、分化不良(过度1组织器官发育不全细胞增殖仁分化不全一一妤瘪发生【细胞增殖过程】【CellcyclCellc
2、ycleisdefinedasaperiodfromtheendofonedivisiontothebeginningofnextdivisionofaproliferativecel1细胞周期分期(BystagesGiSGovM*细胞周期的控制(Regulationofthecellcycle)RegulationofthecellcycleEextracellularsignalsE1.细胞周期自身控制(Regulationofintracellularsignals)细胞周期调控机制的核心是一组周期素依赖性蛋白激酶(Cyclindependentkinase,CDKsKeyspot:Cy
3、cjp、CDKs、CDJ、Checkpointofcellcycle。目Cyclin、CDKs、CDIaCyclin【c_assification】CyclinB1、CyclinA、CyclinE、CyclinDiDoDa.FG,HT。100aa组成cyclinbox1i2理图Cyclinbox结构与功能CyclinCDK心Cyciin周期变化图伟。=心nCyclin-CDK复合物及其相关蛋自Cyclins相关CDKSa刑仪朱英蝴白低物陆觞人CDKiy,CDK2“S+G2丽pi073E2F,p21,PCNARbubiquitinB(B1.B2)“CDK1(cde2)G2,Mp21,PCNARb
4、ubiquitinCCDK8G1-PESTD(D1-3)CDKd(25.6)G1Rbjp21,p27,p15,p16,PCNARb“PESTECDK2G1+G1,Sp1074E2F,p21,PCNARb“PESTF-S$-G-G1-HCDK7G1.S,G2,M-cDK14.6-回Cyclins降解主要是泛素-虾白酶佛进行泛素化降解(bJPoyubiquiinatonofmitoccyeinProteasome,Degraded一cyclnpeptdesECDKs家族CDKs是一组丝氨酸/苏氨酸蛎自激酶。称为CDKi_o。【CDK1活化启动cellcycle】ThrltsTyrs披制部位去磷酸化林CDK江化渡膳(CDKactivationKinaseCAK)
