《2010+ACR+EULAR+类风湿关节炎分类标准》由会员分享，可在线阅读，更多相关《2010+ACR+EULAR+类风湿关节炎分类标准（53页珍藏版）》请在金锄头文库上搜索。
1、2010 ACR/EULAR Classification Criteria for Rheumatoid ArthritisPublished in the September 2010 Issues of A&R and ARDPhases of the ProjectPhase 1Data analysisPhase 2Consensus processPhase 3Integration of 1 and 2Predictors of MTX initiationFinal CriteriaDeterminants of high probability of RAIncrease f
2、easibilityPhase 1Data Driven ApproachPhase 1: Patients and Methods Patients EARLY ARTHRITIS COHORTS 3115 patients from 9 cohorts Inflammatory arthritis (no other definite diagnosis) of 1-10 medium-large, asymmetric 10.2 1.02 11-10 medium-large, symmetric 16.1 1.61 1.51-3 small 21.2 2.12 24-10 small
3、28.8 2.88 310, including at least one small joint 50.8 5.08 5SEROLOGY (RF or ACPA)0 (3xULN) 33.9 3.39 3.5ACUTE PHASE REACTANTS (ESR or CRP)Normal 0 0 0Abnormal 5.9 0.59 0.5SYMPTOM DURATION1-10 medium-large, asymmetric 10.2 1.02 11-10 medium-large, symmetric 16.1 1.61 1.51-3 small 21.2 2.12 24-10 sma
4、ll 28.8 2.88 310, including at least one small joint 50.8 5.08 5SEROLOGY (RF or ACPA)0 (3xULN) 33.9 3.39 3.5ACUTE PHASE REACTANTS (ESR or CRP)Normal 0 0 0Abnormal 5.9 0.59 0.5SYMPTOM DURATION1-10 medium-large, asymmetric 10.2 1.02 11-10 medium-large, symmetric 16.1 1.61 1.51-3 small 21.2 2.12 24-10
5、small 28.8 2.88 310, including at least one small joint 50.8 5.08 5SEROLOGY (RF or ACPA)0 (3xULN) 33.9 3.39 3.5ACUTE PHASE REACTANTS (ESR or CRP)Normal 0 0 0Abnormal 5.9 0.59 0.5SYMPTOM DURATION10 joints (at least one small joint) 5SEROLOGY (0-3)SYMPTOM DURATION (0-1)ACUTE PHASE REACTANTS (0-1)2010
6、ACR/EULARClassification Criteria for RAJOINT DISTRIBUTION (0-5)1 large joint 02-10 large joints 11-3 small joints (large joints not counted) 24-10 small joints (large joints not counted) 310 joints (at least one small joint) 5SEROLOGY (0-3)Negative RF ANDnegative ACPA 0Low positive RF ORlow positive
7、 ACPA 2High positive RF ORhigh positive ACPA 3SYMPTOM DURATION (0-1)ACUTE PHASE REACTANTS (0-1)2010 ACR/EULARClassification Criteria for RAJOINT DISTRIBUTION (0-5)1 large joint 02-10 large joints 11-3 small joints (large joints not counted) 24-10 small joints (large joints not counted) 310 joints (a
8、t least one small joint) 5SEROLOGY (0-3)Negative RF ANDnegative ACPA 0Low positive RF ORlow positive ACPA 2High positive RF ORhigh positive ACPA 3SYMPTOM DURATION (0-1)10 joints (at least one small joint) 5SEROLOGY (0-3)Negative RF ANDnegative ACPA 0Low positive RF ORlow positive ACPA 2High positive
9、 RF ORhigh positive ACPA 3SYMPTOM DURATION (0-1)10 joints (at least one small joint) 5SEROLOGY (0-3)Negative RF ANDnegative ACPA 0Low positive RF ORlow positive ACPA 2High positive RF ORhigh positive ACPA 3SYMPTOM DURATION (0-1)10 joints (at least one small joint) 5SEROLOGY (0-3)Negative RF ANDnegat
10、ive ACPA 0Low positive RF ORlow positive ACPA 2High positive RF ORhigh positive ACPA 3SYMPTOM DURATION (0-1)10 joints (at least one small joint) 5SEROLOGY (0-3)Negative RF ANDnegative ACPA 0Low positive RF ORlow positive ACPA 2High positive RF ORhigh positive ACPA 3SYMPTOM DURATION (0-1)10 joints (a
11、t least one small joint) 5SEROLOGY (0-3)Negative RF ANDnegative ACPA 0Low positive RF ORlow positive ACPA 2High positive RF ORhigh positive ACPA 3SYMPTOM DURATION (0-1)10 JOINTS”- At least onesmall joint- Additional joints include: temporomandibular, sternoclavicular, acromioclavicular, and others (
12、reasonably expected in RA) DefinitionsDefinitions6 = definite RAJOINT DISTRIBUTION (0-5)1 large joint 02-10 large joints 11-3 small joints (large joints not counted) 24-10 small joints (large joints not counted) 310 joints (at least one small joint) 5SEROLOGY (0-3)Negative RF ANDnegative ACPA 0Low p
13、ositive RF ORlow positive ACPA 2High positive RF ORhigh positive ACPA 3SYMPTOM DURATION (0-1)ULN but 3xULN High positive: 3xULNDefinitions6 = definite RAJOINT DISTRIBUTION (0-5)1 large joint 02-10 large joints 11-3 small joints (large joints not counted) 24-10 small joints (large joints not counted)
14、 310 joints (at least one small joint) 5SEROLOGY (0-3)Negative RF ANDnegative ACPA 0Low positive RF ORlow positive ACPA 2High positive RF ORhigh positive ACPA 3SYMPTOM DURATION (0-1)10 joints4-10 small joints1-3 small joints2-10 large jointsNoNoNoNoBranch 1YesBranch 2YesBranch 3YesYesRABranch 4Branc
15、h #1: Polyarticular PresentationRARASerology:Low/high positive?Duration:6 weeks?APR: Abnormal?NoYesNoNoYesYesBranch #110 jointsBranch #2: Presentation with Oligo/Polyarticular Small JointsRADuration: 6 weeks?Serology: high positive?Serology: low positive?APR: Abnormal?NoYesBranch #24-10 small joints
16、YesYesNoNoYesRABranch #3: Presentation with Mono/Oligoarticular Small JointsNoBranch #31-3 small jointsRARADuration:6 weeks?Serology:High positive?APR:abnormal?Duration:6 weeks?Serology:Low positive?YesYes YesNoNoNoNoYesYesBranch #3: Presentation with Oligo/Polyarticular Large JointsBranch #42-10 large jointsRARADuration: 6 weeksSerology: +APR: AbnormalYesYesYesNoNoNoSTART(eligible patient)RARA RARA RARA R
