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1、M. F. Egan, M. Kojima, J. H. Callicott, T. E. Goldberg, B. S. Kolachana, E. Zaistev, A. Bertolino, B. Gold, D. Goldman, M. Dean, B. Lu, (co-corresponding author) and D. R. Weinberger. (2003) The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal
2、function. Cell 112, 257-269. L. Ma, Y. -Z. Huang, J. Valtschanoff, L. Feng, B. Lu, W. Xiong, R. Weinberg, L. Mei. (2003) Ligand-dependent recruitment of the neuregulin signaling complex into neuronal lipid rafts. J. Neurosci. 23, 3164-3175. J. Wang, C. -Q. Chen, B. Lu, and C. -P. Wu. (2003) GDNF acu
3、tely potentiates Ca2+ channels and excitatory synaptic transmission in midbrain dopaminergic neurons. NeuroSignals 12, 78-88. M. Miura, S. Gronthos, M. Zhao, B. Lu, L. W. Fisher, P. G. Robey, and S. Shi (2003) SHED: Stem cells from human exfoliated deciduous teeth. Proc. Natl. Acad. Sci. USA 100, 58
4、07-5812. Y. X. Zhou, M. Zhao, K. Shimazu, K. Sakata, D. Li, C. -X. Deng, B. Lu. (2003) Impairments in cerebellum Purkinje cells and motor function in mice lacking Smad4 in the central nervous system. J. Biol. Chem. 278, 42313 - 42320. J. Du, L. Feng, E. Zaitsev, H. S. Je, X. Liu, and B. Lu. (2003) A
5、ctivity- and tyrosine kinase-dependent facilitation of TrkB receptor internalization in hippocampal neurons. J Cell Biol. In press. Z. G. Luo, H. -S. Je, F. Yang, W. C. Xiong, B. Lu, and L. Mei (2003) Activation of geranylgenanyltransferase is essential for Agrin-induced AChR clustering. Neuron In p
6、ress. S. X. Bamji, K. Shimazu, N. Kimes, J. Huelsken, W. Birchmeier, B. Lu, L. F. Reichardt. (2003) Regulation of presynaptic assembly and maintenance by -catenin. Neuron In Press. F. Yang, X. He, J. Russell, and B. Lu. (2003) Ca2+ influx independent transmitter release mediated by mitochondrial Na+
7、-Ca2+ exchanger and protein kinase C. J. Cell Biol. In press.,2003 research articles,What Is the Purpose of Doing Research?,It is not about the number of papersIt is not about the impact factor of the papersIt is not about the Nobel Prize,Publish or perish1 Nature = 10 JBC,Good Research Is the Key,M
8、y English is not goodThey are biased against Chinese (foreigners),What Is a First-Class Paper/Research?,Major advance in a classic field 干细胞是如何分化成特定组织细胞的，胆固醇在人体的正常功用New techniques and methods that can be widely used 人类基因组研究中的自动测序技术 , PCR, Patch clamp, Ca2+ Imaging, GFPDiscoveries with obvious practi
9、cal implications AIDS virus receptor 的发现, 老年痴呆症基因的发现 Conceptual breakthrough, novel ideas 神经营养因子可以促进学习记忆, RNA干扰现象 Challenge to traditional views, break dogma 脑内有可分裂的神经干细胞，打破了传统观念 Opening up new area, cross board “细胞凋亡”现象的发现, 开辟了新的科研领域,What Is a Mediocre Paper/Research?,Horizontal growth I made the d
10、iscovery in rats, you find the same in cat.Filling gaps EGF activates JNK which is known to induce c-Jun expression. You show that EFG enhances c-Jun expression. Working out details I found NO induces the production of cGMP, you work out dose response and time course.Support existing idea, “me too”
11、EGF-R endocytosis requires dynamin, PDGF-R too.Follow up CREB binds to CRE. Working out CRE sequence.Incomplete study, preliminary,How to Read Scientific Papers?,The Gilbert wayKeep these in mind when you readWhat is the major question addressed in this paper? Is this question important and why?What
12、 are the approaches used in this paper, and whether they are adequate for the questions?What are the novel idea or using innovative approaches?What is the concept coming out of this paper?Do the results presented support this new concept? Weekly reading of CNS titlesCritical, appreciative,What Makes
13、 Good Science?,Important and significantOriginal and innovativeSolid and rigorousUnique and unusual,Novelty is essential,语不惊人誓不休,The evaluation process,Editorial staff Board of Reviewing Editors,20-30%,REJECT,REVIEW,REJECT,70%,ACCEPT (10%),70%,20%,6%,4%,Should your paper go to CNS?,Is it your best e
14、ver?Will it have a big impact?Does it interest scientists in other fields?Does it overturn conventional wisdom?Work that represents a large step forward solution to long-standing problem different way of thinking broad implications,What helps:,Convincing data Appropriate controls Careful presentatio
15、n Consideration of all viable alternatives,What doesnt help,The minimal publishable unit. Excessive or unfounded speculation Repeat examples of a known phenomenon Insufficient advance over previously published work,Editorial Policies of Different Journals,Cell/Neuron/ImmunityEditorial board does a l
16、ot of reviews. Editors discuss and decideNature sister journalsEditors discuss and decideScienceSpace meeting, board of review editorsPNASCommunicate, contribute, Track COthers,Procedures for High Profile Journals,Pre-submission inquirySubmit/cover letterInitial screenSend out for reviewsReject/soft reject/reviseRebuttalRevise againAccept,significance/importancegeneral interestsunusual/surprise,Initial screening,suggest reviewers, may take onefriends may not always support you“not to review” always honored“soft” and “harsh” reviewers,
