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1、免疫规划中心 National Immunization Programme,流行性乙型脑炎监测和控制工作进展情况 The Progress of JE Surveillance and Control,主要内容 Main contents,概述 Summary 2006年乙脑疫情 epidemic of JE in 2006 乙脑疫苗预防接种工作 vaccination of JE vaccine 全国乙脑监测点工作介绍 Introduce of the national JE sentinel site 流脑、乙脑等疾病监测合作项目介绍 Introduce of the AMES proj
2、ect 建议 Recommendations,1951-2006年乙脑发病趋势 The trend of JE incidence from 1951 to 2006,19512006年全国乙脑报告发率,发病率 Incidence rate,1991, 1994, 1999 和2005年乙脑发病分省分布 Distribution of JE by province 1991, 1994, 1999 and 2005,3 0.5 0.3 0.2 0.01 0,1991,1994,1999,2005,2006年全国乙脑报告情况 Reporting status quo of JE in 2006,
3、30个省份报告病例 30 provinces have case reported青海省无病例报告No JE cases in Qinghai province全国报告7643例，死亡463例total 7643 cases reported nationwide, with 463 death cases.病死率6.1%。Case fatality rate was 6.1%发病率0.58/10万； incidence rate was 0.58/100,000比上一年度发病率上升49%。 There 49% increase compared to that of last year,20
4、06年全国乙脑分省发病数 The JE cases by province nationwide 2006,1 点= 1 病例 1dot=1case,2006年乙脑分省发病率（1/10万） The incidence rate of JE by province 2006,乙脑发病季节性 Seasonal variation of JE incidence,months,Year Year Year,Cases,2006年乙脑年龄别发病率 The age specific incidence rate of JE in 2006,Female Male,乙脑病例年龄构成变化 the chang
5、e of age composition of JE case,2006年全国乙脑报告病例职业构成 Composition of JE case by occupation in 2006,15 省将乙脑疫苗纳入免疫规划 15 provinces integrate JE vaccine into EPI,乙脑疫苗预防接种 Immunization of JE vaccine,2004年乙脑疫苗使用量：6184万人份 The amount of vaccine used in 2004: 61.84 million person-doses 灭活疫苗： 1388万人份 Deactivated
6、vaccine: 13.88 million person-doses 减毒活疫苗：4796万人份 Attenuated live vaccine: 47.96million person-doses 2004年与2003年相比，增加6.9% Compare 2004 to that of 2003, there is 6.9% increase,乙脑疫苗接种情况 The status of JE vaccine immunization,未接种或未及时接种疫苗原因 The reason of not being immunized or in time. 主要原因-“一年只接种一次”、 “不
7、知道接种时间” 、“不知道要接种疫苗” Main reason: “vaccinate once a year”, “do not know the time of vaccination”, “do not know need to be vaccinated” 随着接种针次的增加“不知道要接种疫苗”所占比例增加With the increase of dose vaccinated, the proportion of “do not know need to be have vaccine to be vaccinated”,资料来源：2005陕西省控制乙脑示范项目调查资料 Data s
8、ources: From the information of Investigation on JE control demonstration project of Shaanxi Province 2005,乙脑相关知识知晓情况 Awareness rate of Knowledge related to JE,家长对乙脑知晓率偏低 Parents with low awareness of JE knowledge 43.9%不知道乙脑 43.9% parents do not know JE知道乙脑的家长中，66.4%不知道传播途径。66.4% of parents know JE
9、but they do not the route of transmission61.2%知道乙脑疫苗，其中多数认为接种乙脑疫苗很重要，88.8%不知道乙脑疫苗第1针接种时间 。61.2% of parents know JE vaccine, and most of them think it is important to vaccinate JE vaccine, 88.8% of them do not know the time of first dose of JE vaccination 86.4%家长接受乙脑疫苗，源于可预防严重疾病。86.4% of parents acce
10、pt JE vaccine, because it can prevent important disease,资料来源：2005陕西省控制乙脑示范项目调查资料 Data sources: From the information of Investigation on JE control demonstration project of Shaanxi Province 2005,乙脑疫苗与麻疹疫苗联合接种 JE vaccine coadministration with Measles vaccine,方法method 健康儿童8月龄接种LJEV，9月龄接种MV 组1 (n=98); G
11、roup 1, Healthy infants receive LJEV at 8 months and MV at 9 months.LJEV与 MV同时在9月时接种 组2 (n=235); Group 2, LJEV and MV coadministered at 9 months. 9月接种MV10月接种LJEV 组3 (n=223)Group 3, MV at 9 months and LJEV at 10 months. 免前，接种后1月测抗体滴度test titers before vaccination and 1 months postvaccination,Data sou
12、rce, Salvacion Gatchalian1, Yafu Yao, Benli Zhou, et al. Measles vaccine immunogenicity after coadministration with live attenuated Japanese encephalitis vaccine shows equivalence to that of measles vaccine given alone.,结果results,麻疹抗体阳转率Measles seroprotection rates： 组1：100.0%，组2：95.5% ，组3： 100.0% 麻疹
13、抗体GMT： 组1：3241，组2：2471， 组3：3205 乙脑抗体阳转率JE antibodies seroprotection rates： 组1：92.1%，组2：90.5% ，组3： 90.6%,Data source, Salvacion Gatchalian1, Yafu Yao, Benli Zhou, et al. Measles vaccine immunogenicity after coadministration with live attenuated Japanese encephalitis vaccine shows equivalence to that
14、of measles vaccine given alone.,免疫后1个月抗体滴度变化,Data source, Salvacion Gatchalian1, Yafu Yao, Benli Zhou, et al. Measles vaccine immunogenicity after coadministration with live attenuated Japanese encephalitis vaccine shows equivalence to that of measles vaccine given alone.,与单独给予任一剂次疫苗比较,Data source,
15、Salvacion Gatchalian1, Yafu Yao, Benli Zhou, et al. Measles vaccine immunogenicity after coadministration with live attenuated Japanese encephalitis vaccine shows equivalence to that of measles vaccine given alone.,1个月后抗体阳性率结果比较,Data source, Salvacion Gatchalian1, Yafu Yao, Benli Zhou, et al. Measle
16、s vaccine immunogenicity after coadministration with live attenuated Japanese encephalitis vaccine shows equivalence to that of measles vaccine given alone.,结论conclusions,同时接种阳转率没有显著差异The coadministration of LJEV and MV at 9 months of age showed antimeasles and anti-JE immunogenicity equivalent to LJEV and MV given separately. 安全性相似Safety profiles were comparable. 可以同时接种coadministrate at the same time,2006年乙脑国家级监测点分布 Distribution of National Surveillance Site 2006,
