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1、DZ,2010,31(11) :100null103Progress in Veterinary Medicinenull)%)nullNDMnull1C*徐利娟,黄null 敏*(2Bv3S/,+610041)null nullKnull1:金属nullnullnull内酰胺酶是nullnull内酰胺酶中的B亚群,NDMnull1是一种近来发现的新的金属nullnullnull内酰胺酶,携带NDMnull1基因的细菌几乎对所有抗生素耐药,所以被称为null超级细菌nullb论文从null超级细菌nullNDMnull1的起源a分子特点a传播途径以及预防措施等方面进行了介绍bnull null
2、1oM:超级细菌;NDMnull1;金属nullnullnull内酰胺酶;细菌耐药ms|:R978.1DSM: BcI|:1007null5038( 2010) 11null0100null04null null11928M?BF3,i1941M5,F)0?Z,M?CF3,5200bF3rb-,5KF3cnullnull=33 ,h),#?Z;ahanullnull=dnullnull=F3,yNz%)+VPF3rbF3F)Kr,V79V?/h)34b?C,GSKnull299423?F3300%),P%)T35null36 ,V?VNDMnull1,V5B37b2.3null NDMnull
3、1a.lo#n2.3. 1 null NDMnull1的症状nullS=M1h,-,null)%)nullW%bVzNDMnull1y%)Bv)kXu),v)kXu),9V?DNMnull1Bxbv)1,101:null)%)nullNDMnull1C.e,0,|s,U,|;kXu)1VC?Oh?,0,&b2.3. 2null NDMnull1的传播途径null NDMnull1yi,?%)W?3yM,V%)W1.l,*t3,8#1Z,Da3rb%).lZT,Vnull)%)null.lo381/3:(1)b.lbNDMnull1hUu:H,8=A8b,tA8c%)V?zNDMnull1y,T
4、b(%),5V?$b(2)(.lbNDMnull1(VZV?=zNDMnull1y%),tZT#HVab!,*Q(HV?$b(3)s.lb1WbA9F,bs%)Kn,TNDMnull1h,5bV?zNDMnull1y%)b2.3. 3null NDMnull1的预防措施null NDMnull14,9Ac,|nVE$bn101:F)P0!m,!z38;J,F.nullnull=F34J.S=_D, 2007, 28(6): 566null568.24 null M urphy T A, Simm A M, Toleman M A, et al. BiochemicalCharacterizat
5、ion of the Acquired MetallonullnullnullLactamase SPMnull1from Pseudomonas aeruginosa J. Antimicrobial Agents andChemotherapy, 2003, 47(2): 582null587.25 null Lee K, Yum J H, Yong D, et al. Novel acquired metallonullnullnulllactamase gene, blaSIMnull1, in a class 1 integron fromAcinetobacter baumanni
6、i clinicalisolates from KoreaJ. Annulltimicrob Agents Chemother, 2005, 49(11): 4485null4491.26 null Yong D, Toleman M A, Giske C G, et al. Characterization ofa new metallonull lactamase gene, blaNDMnull1, and a novel enullrythromycin esterase gene carried on a unique genetic strucnullture in Klebsie
7、lla pneumoniae sequence type 14 from IndiaJ. Antimicrob Agents Chemother, 2009, 53( 12): 5046null5054.27 null Deshpande P, Rodrigues C, Shetty A, et al. New Delhi Metnullallonullb lactamase ( NDMnull1) in enterobacteriaceae: treatmentoptions with carbapenems compromisedJ. The Associationof Physician
8、s of India, 2010, 58: 147null150.28 null M uir A, Weinbren M J. New Delhi metallonullnullnulllactamase: acautionary tale J. Hospital Infection, 2010, 75(3): 239null240.29 null Pankey G A. Tigecycline J. Antimicrobial Chemotherapy,2005, 56(3): 470null480.30 null Li J, Nation R L, Turnidge J D, et al.
9、 Colistin: the renullemernullging antibiotic for multidrugnullresistant Gramnullnegative bacterinullal infectionsJ. Lancet Infect Dis,2006, 6(9): 589null601.31 null CDC Home. Detection of enterobacteriaceae isolates carryingmetallonullbetanulllactamasenullUnited States, 2010 N. M orbidityand M ortal
10、ity Weekly Report, 2010null6null25, 59(24): 750.32 null Boland V. First case of NDMnull1 Superbug now confirmed inOntarioEB/OL. Digital Journal, 2010null8null21, http: /www.digitaljournal. com/article/296385.33 null Queenan A M, Bush K. Carbapenemases: the versatilenullnulllacnulltamasesJ. Clin Micr
11、obiolRev, 2007, 20(3): 440null458.34 null Health Protection Agency. M ultinullresistant hospital bacterialinked to India and PakistanN. Health Protection Report,2009null7null3.35 null Bax B D, Chan P F, Eggleston D S, et al. Type IIA topoinullsomerase inhibition by a new class of antibacterial agentsJ.Nature, 2010, 466: 935null940.36 null Carroll J. 299423: GSK cites progress with a newnullgen antibinulloticEB/OL. FierceBiotech, 2010null8null5, http: /www. fiercenullbiotech. com/story/299423nullgsknullcitesnullprogressnullnewnullgennull
