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1、慢性阻塞性肺病的新进展,清华大学第一附属医院呼吸科,GOLD颁布的COPD全球策略 2014年最新更新慢性阻塞性肺疾病急性加重(AECOPD)诊治中国专家共识(草案),Global Strategy for Diagnosis, Management and Prevention of COPD, 2013: Chapters,Definition and Overview Diagnosis and Assessment Therapeutic Options Manage Stable COPD Manage Exacerbations Manage Comorbidities,Updat
2、ed 2013, 2013 Global Initiative for Chronic Obstructive Lung Disease,COPD的定义,COPD 是一种可以预防和可以治疗的常见疾病, 其特征是持续存在的气流受限。气流受限呈进行性发展, 伴有气道和肺对有害颗粒或气体所致慢性炎症反应的增加。 急性加重和合并症影响患者整体疾病的严重程度。,COPD气流受限的发病机制,AIRFLOW LIMITATION, 2013 Global Initiative for Chronic Obstructive Lung Disease,COPD的危险因素,肺的生长发育 性别 年龄 呼吸道感染
3、社会经济条件 哮喘 气道高反应性 慢性支气管炎,基因 有害颗粒暴露吸烟职业粉尘，有机物，无机物室内燃料燃烧和通风不良室外空气污染, 2013 Global Initiative for Chronic Obstructive Lung Disease,COPD的危险因素,Genes,Infections,Socio-economic status,Aging Populations, 2013 Global Initiative for Chronic Obstructive Lung Disease,Global Strategy for Diagnosis, Management and
4、Prevention of COPD, 2013: Chapters,Definition and Overview Diagnosis and Assessment Therapeutic Options Manage Stable COPD Manage Exacerbations Manage Comorbidities,UPDATED 2013, 2013 Global Initiative for Chronic Obstructive Lung Disease,SYMPTOMS,chronic cough,shortness of breath,EXPOSURE TO RISK F
5、ACTORS,tobacco,occupation,indoor/outdoor pollution,SPIROMETRY: Required to establish diagnosis,COPD的诊断,sputum, 2013 Global Initiative for Chronic Obstructive Lung Disease,COPD的诊断,任何患有呼吸困难、慢性咳嗽或多痰的患者, 并且有暴露于危险因素的病史, 在临床上需要考虑COPD 的诊断 。 作出COPD 的诊断需要进行肺功能检查, 吸入支气管扩张剂之后FEV1 /FVC 0. 70 表明存在气流受限, 即可诊断COPD。
6、,COPD评估,COPD 评估的目的是决定疾病的严重程度, 包括气流受限的严重程度, 患者的健康状况和未来的风险程度( 例如急性加重、住院或死亡) , 最终目的是指导治疗。, 2013 Global Initiative for Chronic Obstructive Lung Disease,COPD的评估,症状评估 气流受限采用肺功能严重度分级 急性加重风险评估 合并症评估, 2013 Global Initiative for Chronic Obstructive Lung Disease,*改良英国MRC 呼吸困难指数( modified british medical resear
7、ch council, mMRC ) *COPD 评估测试( COPDassessment test, CAT) 。,症状的评估, 2013 Global Initiative for Chronic Obstructive Lung Disease,Global Strategy for Diagnosis, Management and Prevention of COPD Modified MRC (mMRC)Questionnaire, 2013 Global Initiative for Chronic Obstructive Lung Disease,气流受限的评估,气流受限程度仍
8、采用肺功能严重度分级, 即FEV1 占预计值80% 、50% 、30% 为分级标准。COPD 患者的气流受限的肺功能分级分为4 级( Grades) , 即: GOLD 1轻度,GOLD 2中度, GOLD 3重度, GOLD 4非常严重。 使用支气管扩张剂后，患者肺功能FEV1 /FVC 0. 70COPD 分期( Stage) 的概念已经被废除, 2013 Global Initiative for Chronic Obstructive Lung Disease,Global Strategy for Diagnosis, Management and Prevention of COP
9、D Classification of Severity of Airflow Limitation in COPD*,In patients with FEV1/FVC 80% predicted GOLD 2: Moderate 50% FEV1 80% predictedGOLD 3: Severe 30% FEV1 50% predictedGOLD 4: Very Severe FEV1 30% predicted*Based on Post-Bronchodilator FEV1, 2013 Global Initiative for Chronic Obstructive Lun
10、g Disease,急性加重风险评估,采用急性加重病史和肺功能评估急性加重的风险, 上一年发生2 次或以上的急性加重或FEV1% pred 2,1,0,(C),(D),(A),(B),mMRC 0-1 CAT 2 CAT 10,Symptoms (mMRC or CAT score), 2013 Global Initiative for Chronic Obstructive Lung Disease,Combined Assessment of COPD,(C),(D),(A),(B),mMRC 0-1 CAT 2 CAT 10,Symptoms (mMRC or CAT score),I
11、f mMRC 0-1 or CAT 2 or CAT 10:More Symptoms (B or D),首先Assess symptoms first, 2013 Global Initiative for Chronic Obstructive Lung Disease,Combined Assessment of COPD,Risk (GOLD Classification of Airflow Limitation),Risk (Exacerbation history), 2,1,0,(C),(D),(A),(B),mMRC 0-1 CAT 2 CAT 10,Symptoms (mM
12、RC or CAT score),If GOLD 1 or 2 and only 0 or 1 exacerbations per year: Low Risk (A or B)If GOLD 3 or 4 or two or more exacerbations per year:High Risk (C or D) (One or more hospitalizations for COPD exacerbations should be considered high risk.),其次急性加重风险的评估, 2013 Global Initiative for Chronic Obstr
13、uctive Lung Disease,Combined Assessment of COPD,Risk (GOLD Classification of Airflow Limitation),Risk (Exacerbation history), 2,1,0,(C),(D),(A),(B),mMRC 0-1 CAT 2 CAT 10,Symptoms (mMRC or CAT score),Patient is now in one of four categories:A: Less symptoms, low riskB: More symptoms, low riskC: Less
14、symptoms, high riskD: More symptoms, high risk,综合评估, 2013 Global Initiative for Chronic Obstructive Lung Disease,Combined Assessment of COPD,Risk (GOLD Classification of Airflow Limitation),Risk (Exacerbation history), 2,1,0,(C),(D),(A),(B),mMRC 0-1 CAT 2 CAT 10,Symptoms (mMRC or CAT score), 2013 Global Initiative for Chronic Obstructive Lung Disease,Combined Assessment of COPD, 2013 Global Initiative for Chronic Obstructive Lung Disease,Global Strategy for Diagnosis, Management and Prevention of COPD Differential Diagnosis: COPD and Asthma,
