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1、1强迫症强迫症, ,图雷特综合症的遗图雷特综合症的遗 传结构传结构( (原文及背景知识原文及背景知识) )导读：就爱阅读网友为您分享以下导读：就爱阅读网友为您分享以下“强迫症强迫症,图雷特综合图雷特综合症的遗传结构症的遗传结构(原文及背景知识原文及背景知识)”的资讯，希望对您有所帮的资讯，希望对您有所帮助，感谢您对助，感谢您对 的支持的支持!Insights into the genetic architecture of OCD, T ourette syndromeAn international research consortium led by investigators at M
2、assachusetts General Hospital (MGH) and the University of Chicago has answered several questions about the genetic background of obsessive-compulsive disorder (OCD) and Tourette syndrome (TS), providing the first direct confirmation that both are highly heritable and also revealing major differences
3、 between the underlying genetic makeup of the disorders. Their report is being published in the October issue of the open-access journal PLOS Genetics. t looking for individual genes. By examiningthe properties of all genes that could contribute to TS or OCD at once, were actually testing the whole
4、haystack and asking where were more likely to find the needles.Using GCTA, the researchers analyzed the same genetic datasets screened in theMolecular Psychiatry reports - almost 1,500 individuals affected with OCD compared with more than 5,500 controls, and nearly TS 1,500 patients compared with mo
5、re than 5,200 controls. To minimize variations that might result from slight difference in experimental techniques, all genotyping was done by collaborators at the Broad Institute of Harvard and MIT, who generated the data at the same time using the same equipment. Davis was able to analyze the resu
6、lting data on a chromosome-by-chromosome basis, along with the frequency of the identified variants and the function of variants associated with each condition.The results found that the degree of heritability for both 5disorders captured by GWAS variants is actually quite close to what previously w
7、as predicted based on studies of families impacted by the disorders. missing heritability,explains Scharf. s mind, eventually causing severe . Many of us imagine an obsession as something desirable and pleasant - but for a person with OCD, the obsession is disturbing, unpleasant and frightening.A co
8、mpulsion is a repetitive behavior carried out by the person with the obsessivethought as a means of preventing that obsession from occurring, or relieving the it cuases.For example: A person may shower every time they touch another person, go to the toilet, or go outside, because they are scared of
9、catching a disease - the obsession is catching 8the disease while the compulsion is to have a shower.According to Medilexicons , Obsessive-Compulsive Disorder is s normal routine, occupational functioning, or usual social activities or relationships with others.s thoughts are dominated by a constant
10、 obsessiveconcern or fear, such as dirt, a burglar breaking into the house, running somebody over while driving, etc.? Anxiety - the obsessive thoughts trigger a sensation of extreme anxiety andanguish.? Compulsion - a pattern of compulsive behaviors are adopted to relieve thedistress and anxiety, t
11、his may involve washing ones hands (possibly many times or for a long time), locking the house in a set pattern before leaving, positioning things around the house in a orderly or symmetrical away, etc.10? Temporary relief - the compulsive behaviors help relieve some of the symptomsof anxiety. Howev
12、er, the obsession soon returns, and with it extreme anxiety, and the cycle repeats itself again and again and again. Obsessive thoughtsFor people with OCD, the obsessions are persistent, unwelcome, and repeated images, ideas, impulses or thoughts that appear uncontrollably and do not seem to make an
13、y sense. They interfere with other thoughts or when the patient is trying to do other things. We all get those unpleasant or unwelcome thoughts now-and-again, perhaps a worry about being made redundant or fired, or one may wonder whether a partner is being unfaithful. However, if you are able to put
14、 these types of concerns into context and can carry on with your day-to-day life, or if they are not worries of little substance and do not boomerang back and forth all day long, you do not have the symptoms of OCD.11On the other hand, if the thought is persistent, unwanted, you dont like it, and it
15、 dominates your mind so much that it interrupts other thoughts, you could have an OCD-type obsession.Below are the most common obsessions that afflict people with OCD: ? Deliberately harming others - fearing that one might deliberately hurt somebodyelse. Even though the idea of attacking somebody ma
16、y seem abhorrent, the obsession is there and the thought (fear) keeps coming back.? Accidentally harming yourself or others - such as leaving the stove on, settingthe house on fire, leaving something on the stairs and somebody trips over it.? Contamination - fearing becoming infected, or ill because 12of some substance.? Order and symmetry - there may be a powerful and uncontrollable urge to haveeverything looking orderly and/or symmetrical. The sufferer may go into the kitchen regul
