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1、更年期综合征激素替代疗法围绝经期妇女的生理需求HRT增加乳腺癌的发生率HRT与CHD的关系8庞NerincreosedmammagrnhiciensityNoendomsinialproieraiionTrealsvaoinalairophyPreventsposimencpausalbonelossE人EAoeyeoraFlgureB:Estimatedcunulativenumberofbreastcancersdiagnosed训1.0OOnever-usersofHRT.1.0O0usersofHRTfor5gears.andj.000usersofHRTfor10yeorsfCoab
2、orativeCrouponHormionalFoctorsiBreastCancer1997对g诊(2763)(2630(Q506)(2392)(1435)113)Yearsoffollowup(numberatiskyRlgure2:HERS:primaryCHDeyentsfHufleyefal1998口阊2河MNorrusers_.Usery8Figure1:Effectofestrogenraplocementfheropy0fstrviyallogercoronaryarterybypossSurgeryuWiyanetal1997史Tabe交Specifcbindinginiti
3、estnucjeqreceptoys吊MCF-7c3e3BOH-tiboloneA-tiboloneisomerBindingaffinity+yesi.nAdaptedfromNarliewicefal19905Flgure9:Moodscores加postmienopausalWomenfJaxet011987史Meontorerhoffghey*J-*101244168。20。2224weekc一-Plocebo0osEamclsucoinone2-4matdey仪Ooa1)Uviol25mardaytpaoo0Earadiolvolerte2maisaytpaootCoriuaoied
4、esmogens0425maideytpaoo2Rigure10:IncizencecfhotflushtesinfourgroupsafpostmenopausalwomenunalergoingHRTanaincontroVolpeefal198G口gparregEresctarinvitriccomaucurscermeoareeyFserucicol2rnggyuspeETrAfglctproueeengeanzpormsGHDnnincurztia丁eutou.Com2MeCoysexscaleEJNEIA17Iresrodiol(2maldolinarefhisieroneoceole1mgiao“p005belweengroupsRigure12:LinatlibidoandsexualenjourmentINathdrst-.Bdtissral1997寸
