_丹参酮ⅡA药理作用的研究进展_丹参酮ⅡA药理作用的研究进展

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1、50nullA0TZ张萌涛1, 2 (8),钱亦华1null ,唐安琪2 (,n)( 1.YvD8F,*3,%hM1yLi,710061; 2.gSDhu,710061)ms|: R96null null null null nullDSM: Anull null null null nullcI|: 1006null2084( 2010) 17null2661null04:西安市科技计划项目资助(GG04145, GG06175); 横向课题( 2010W 007)null nullK1:丹参酮nullA具有多种药理作用,能对抗心肌急性缺氧损伤a抗心律失常a改善血管平滑肌功能,对缺血/再灌注

2、引起的组织损伤具有保护作用b丹参酮nullA通过对肿瘤细胞的杀伤a诱导分化和凋亡a抑制侵袭和转移的机制发挥抗肿瘤作用b丹参酮nullA还具有神经保护作用,将对神经系统疾病防治有重要意义b1oM:丹参酮nullA;心血管作用;抗肿瘤;神经保护;清除氧自由基Research ProgressofPharmacologicActionsofTanshinonenullAnull ZHANG M engnulltao1, 2, QIAN Yinullhua1, TANG A nnullqi2. ( 1. D epartm ent ofH um an Ana tom y and H istologynu

3、llEm bryology, R esearch Institute ofN eurobiology, K ey Labora tory of E nvironm en t and G enes R elated to D isea ses of S ta teM in istry of Educanulltion, X inullan J iaotong University C ollege ofM ed icine, X inullan 710061, Ch ina; 2. The 7th Ward, X inullan ChestM ed icineH osp ita l, X inu

4、llan 710061, C hina )Abstract: The present findings show that TanshinonenullA (T annullA) have extensive pharmacologinullcal effects. Tannull A can counteract the damages induced by acute myocardial hypoxia, including arnullrhythm ias. It improves the function of vascular smooth muscles and protect

5、for the ischem ic/reperfusedtissues. TannullA is capable of killing tumor cells, inducing thedifferentiation and apoptosis, and inhibinullting the invasion and transm ission. T annullA alsohas additional neuroprotectiveeffects, significant forthetreatment and protection of nervous system.Keywords: T

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