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1、 异甘草酸镁抗炎作用机制研究异甘草酸镁抗炎作用机制研究南京医科大学公共卫生学院钟 才 云PRESCRIPTIVE INTEGRATIVE INTERNATIONALAlcoholic liver diseaseViral infection HBV/HCV Chemical liver injuryLiver Liver D Diseaseiseases sDiabetesLiver cancerLiver fibrosisDrug hepatotoxicityNon alcoholic fatty liver diseaseInflammation-associated Liver Dise
2、asesPRESCRIPTIVE INTEGRATIVE INTERNATIONALInt J Mol Sci. 2014 ;15(4):6184-223Obesity and Liver DiseasePRESCRIPTIVE INTEGRATIVE INTERNATIONALAlcoholic Liver DiseaseJ Gastroenterol Hepatol. 2013 ;28 Suppl 1:77-84 PRESCRIPTIVE INTEGRATIVE INTERNATIONALImmunity.2014;40(1):13-24Viral HepatitisPRESCRIPTIV
3、E INTEGRATIVE INTERNATIONALJ Gastroenterol Hepatol. 2011;26 Suppl 1:173-9 Drug HepatotoxicityPRESCRIPTIVE INTEGRATIVE INTERNATIONALNat Rev Immunol. 2014 ;14(3):181-94Liver Fibrosis PRESCRIPTIVE INTEGRATIVE INTERNATIONALCell. 2000 ;100(1):57-70 Hallmarks of CancerPRESCRIPTIVE INTEGRATIVE INTERNATIONA
4、LCell. 2011 ;144(5):646-74 Hallmarks of Cancer: The Next GenerationPRESCRIPTIVE INTEGRATIVE INTERNATIONALCell. 2010 ;140(6):883-99 Role of Inflammation in CancerPRESCRIPTIVE INTEGRATIVE INTERNATIONALClin Cancer Res, 2013; 19(11); 28106Inflammation, Fibrosis, and CarcinogenesisPRESCRIPTIVE INTEGRATIV
5、E INTERNATIONALInt J hepatolo. 2012(10): 1151-1159Reactive Oxygen and Liver InflammationPRESCRIPTIVE INTEGRATIVE INTERNATIONALCell. 2006 ;124(4):823-3 Gastroenterology. 2012;143:11581172Origin of InflammationPRESCRIPTIVE INTEGRATIVE INTERNATIONALNat Rev Immunol. 2014 ;14(3):181-94 Natural History of
6、 Chronic Liver Disease PRESCRIPTIVE INTEGRATIVE INTERNATIONAL J Clin Invest. 2005; 115:26252632 NF-B and InflammationPRESCRIPTIVE INTEGRATIVE INTERNATIONALScience. 2002; 298:1911MAPK and InflammationPRESCRIPTIVE INTEGRATIVE INTERNATIONALPLA/AA and InflammationPRESCRIPTIVE INTEGRATIVE INTERNATIONALCe
7、ll. 2010;140(6):935-50 Production and Release of IL-1PRESCRIPTIVE INTEGRATIVE INTERNATIONAL Cell. 2010;140(6):935-50 Points of Inhibition by Anti-inflammatory AgentsPRESCRIPTIVE INTEGRATIVE INTERNATIONAL Nat Rev Immunol. 2013;13(9):679-92Inhibitors of MAPKsPRESCRIPTIVE INTEGRATIVE INTERNATIONAL Infl
8、ammation. 2012;35(2):560-5Inhibitors of NF-BPRESCRIPTIVE INTEGRATIVE INTERNATIONALExpert Opin. Ther. Patents .2013; 23(3):333-344Inhibitors of PLA2PRESCRIPTIVE INTEGRATIVE INTERNATIONAL 18-甘草酸单一立体异构体镁盐 一类新药 临床应用于抗炎、保护肝脏 抗炎作用机制尚待研究Magnesium Isoglycyrrhizinate 异甘草酸镁（甘美）PRESCRIPTIVE INTEGRATIVE INTERNA
9、TIONAL甘美抑制LPS诱导的炎性细胞因子水平(RAW264.7) PRESCRIPTIVE INTEGRATIVE INTERNATIONAL甘美抑制LPS诱导的NO、iNOS水平(RAW264.7)PRESCRIPTIVE INTEGRATIVE INTERNATIONAL甘美抑制 LPS诱导的 cPLA2 (RAW264.7) PRESCRIPTIVE INTEGRATIVE INTERNATIONAL甘美抑制花生四烯酸代谢酶水平（RAW264.7）PRESCRIPTIVE INTEGRATIVE INTERNATIONAL甘美抑制花生四烯酸代谢脂质炎症介质（RAW264.7）PRES
10、CRIPTIVE INTEGRATIVE INTERNATIONAL甘美对NF-B活性的抑制作用（RAW264.7）PRESCRIPTIVE INTEGRATIVE INTERNATIONAL甘美对MAPK活性的抑制作用（RAW264.7）PRESCRIPTIVE INTEGRATIVE INTERNATIONALPBSDMSOPBS+LPSDMSO+LPSMgIG 0.5+LPSDEX10-6+LPSHYD10-4 +LPSDEX10-5+LPSHYD10-3 +LPSMgIG 1+LPS免疫荧光甘美对细胞内ROS水平的抑制作用（RAW264.7）PRESCRIPTIVE INTEGRATI
11、VE INTERNATIONAL甘美对细胞内ROS水平的抑制作用（RAW264.7） （流式细胞术）PRESCRIPTIVE INTEGRATIVE INTERNATIONAL甘美对血清中细胞因子 水平的影响（小鼠）PRESCRIPTIVE INTEGRATIVE INTERNATIONAL甘美对炎症模型肝脏中细胞因子和NO的影响（小鼠）PRESCRIPTIVE INTEGRATIVE INTERNATIONAL甘美抑制肝脏中PLA/AA介导的炎性介质（小鼠）PRESCRIPTIVE INTEGRATIVE INTERNATIONAL甘美抑制LPS诱导的NF-B 和 MAPK活性（小鼠）PRE
12、SCRIPTIVE INTEGRATIVE INTERNATIONAL 甘美剂量依赖性地抑制由炎症刺激诱导的PLA2/AA、NF-B 和MAPK关键炎性反应信号通路的活性； 甘美明显降低由炎症信号调控的炎性反应酶 （PLA2、COX-2、LOX、iNOS）、脂质炎症介质（前列腺素、 血栓素、白三烯 ）、 细胞因子（IL-1、IL-6 、TNF-） 、细胞趋化因子（IL-8）等炎性因子基因与蛋白表达水平； 与糖皮质激素相比，甘美对主要炎性反应信号通路、关键分子靶标及炎性因子基因表达的调控作用相似，然作用强度相对较弱； 甘美具有明显降低细胞内ROS的作用。结论PRESCRIPTIVE INTEGRATIVE INTERNATIONAL甘美抗炎作用模型PRESCRIPTIVE INTEGRATIVE INTERNATIONAL
