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1、AdvancesinCD30Pathology一HodgkinLymphomaPierPaoloPiccaluga,MD;PhDAssociateProfessorofPathologyHead,MolecularPathologyLaboratoryHematopathologyUnitBolognaUniversitySchoolofMedicineBologna,ltalyMedscapesoucAriGuPathologyofHodgkinLymphomaClassification(WHO2008)HLisclassifiedinto2maintypes:1Lymphocytepre
2、dominantLP-HU一5%。Nodular。Diffuse2,ClassicalHL(CHUJ一95%。ymphocyterich(LRJ。Nodularsclerosis(NS)。Mixedcellularity(MG)。ymphocytedepletion(LD)SwerdiowSH,etalWHOOossWicoonofTumoursofHoematopolsicandIymphoigJisueIARCPress;2008MadscapeImagescouresyofPierpaolopiccalgaMD,PhD国招招标PathologyofHodgkinLymphoma(cont
3、)MorphologyHLischaracterizedby:。Largemultinucleatedcels(50hmlwithprominentnucleoi(Reed-Sternbergcellsordiagnosticcells。MononuclearveriantHodkincells。PopcorncellsinLP-HLThesecellsarediagnosticonlywhenencounteredwithinthetypicalinflammatorymilieu.plefiSAetal1Cinpothol2002.55BKi62176MadscapeImasescouri
4、esyofPierPaoloPiccalugaMD,Ph国招招标ImmunophenotypeinCHLMedscapeImasescounesyofPierpaoloPiccalga,MD,PhD-国ImasescounesyofPierpaoloPiccalga,MD,PhD-EpucangnCD30ExpressioninCHL:MorphologicalVariants973iaggA5ImasescounesyofPierpaolopiccalga,MD,PhD-CD30lsPhysiologicallyExpressedinNormalTissuePresencedetectedu
5、singBER-H2onparaffinsectionsGerminalcenterBcelkFew+Peri/interfoliicularTand8blastsSome+PlasmaceltsFMedullarythymocytesFewGangloncells+Purnjecells+IntestinalymphoidcellsFewFainigetaL8loodL.1995185Ji-14M胁ImagecourtesyofPierPacloPiccalugaMD,PhD-国招招标CD30lsExpressedinManyCancers。Lymphomas:一CutaneousT-cel
6、lymphoma一pleomorphicT-cellymphoma一AngioimmunablasticT-cellymphoma一ymphoepithelioidT-cellymphoma一Timmunoblasticymphoma一bymphomatoidpapulosis一ALCLofTVBJnulltype一Chroniclymphocyticleukeimia一Centrocytiocentroblastic-centrocyticcentroblasticandimmunoblasticymphomas一bymphoplasmocytoid/cytic。Carcinomas:一Br
7、eastgastricpancreas,Iung,urinarybladderendometrium,salivarygland。MalignantmelanomaMedscapeDeutschyf,etaLleuktymphoma.20118528K16411654sssBrentuximabVedotin:MechanismofActionBrentuximabVedotin一AnADCMMAEapotentantitubulinagentProtease-官dleavableAnttCDa0ImonoclonalantibodyMMAE=monomethylauristatinADc=a
8、ntbody-drugconjugateDeutsdhyetaLleuklymphoma20115528JH641.46542.ADC.CD30complex0traffiestososometocD304.MMAEdieruptsmicrotubulenetwork6.ApoptosiMsoucAriGuCD30ExpressionlsStableandConsistent。RetreatmentwithbrentuximabvedotiniseffectiveinCD30+hematologicmalignancies.团“CD30expressionpersistsfollowingtreatmentwithbrentuximabvedotininCD30+|ymphomas.囡*cBeforeTreatmentAfterTreatmenta.foreroonesMD,etalEHA2012.Abstradt0213b,ChenMD,etaLEHA2012.Abstact0203MPeImagescouresyofPierPaclopicalgMD,PhD-国招招标
