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1、CD and CAMJunqi Huang (黄俊琪)CDCluster of Differentiation分化抗原 CAMCell Adhesion Molecules细胞黏附分子 Both surface moleculessurface moleculesReceptors TCRBCRCytokine receptorsComplement receptorsFcRNKRPRP (pattern recognition receptors)DR (death receptors) MHC molecules Costimulation molecules CD/CAMStructur
2、e of CD and CAM Integral membrane proteinTransmembraneSinger grouping: I : Transmembrane once; N out/C in; IgSFStructure of CD and CAM II: Transmembrane once; C out/N in; TNFSFStructure of CD and CAM III: one chain transmembrane several times; TM4-SF CD81 etcSTM SFStructure of CD and CAM: several tr
3、ansmembrane subunit V: GPI connectedCD16b VI: one side GPI connected, the other side TransmembraneBasic structure of CD and CAM Extracellular structureIg domain and IgSFFibronectin type III,FN3 : wsxws motifCytokine receptor domainIntegrin SFC lectin domainComplement control protein (CCP) domainepid
4、ermal growth factor (EGF) domainTNF SFTNFR SFCHD: cytokine receptor domain IGD: IG-like domain FNIIIfibronectin type III repeat(A) gp130;(B) the LIF-R;(C) the OSM-R; (D) soluble receptors (IL-6R, IL-11R). Basic structure of CD and CAMSR(富含半胱氨酸清除剂受体)domainBasic structure of CD and CAMLRR 富含亮氨酸重复序列Bas
5、ic structure of CD and CAM Transmembrane structure2(CD36);3(CD39);4(TM4- SF,CD81);5(CD47);7(STM-SF,IL-8R);GPI -bind Intracellular structurePTK/PTPDDITAM/ITIMCD (cluster of differentiation) A denomination system A particular membrane molecules that are recognized by different monoclonal antibodies ar
6、e grouped together as a cluster of differentiation 。 CD1-CD339(2004.12) 14 groupsWhen stem cell differentiate to different lineage cells or when blood cells are in maturational stages and activation status, the cell surface molecules may appear on or disappear from cell membrane. 1. cell surface mol
7、ecules or marks； 2. expressed on surface of many cells； 3. participating physiological and pathological process白细胞分化抗原leukocyte differentiation antigen, LDA1. LFA-2，sheep red blood cell receptor(绵羊红细胞 受体） 2. Bingding with LFA-3(CD58) 3. On the surface of T cell , thymus cells , NK 4. Functions： Adhe
8、sive function T cell by-pass activation Participating thymus cell differentiation and maturationCD2CD2CD participating in T cell recognition and activation CD31. Coreceptor of TCR 2.Having 5 peptide: 3.On the surface of all T cells 4.Functions ： Forming TCR-CD3 complex Signal transductionCD particip
9、ating in T cell recognition and activation 9-11.Coreceptor of Th activation 2. Ig SF，four domains 3.On the surface of Th 4.Functions ： Stabilizing the MHC-peptide +TCR complex Signal transduction of T cell activation Receptor of HIV infectionCD4CD participating in T cell recognition and activation 9
10、-31. Coreceptor of CTL activation 2. Ig SF 3. On the surface of CTL 4. Functions ： A. adhesive function B. signal transductionCD8CD participating in T cell recognition and activation9-41. Homodimer 2. On the surface of T 3.function：costimulationCD28CD participating in T cell recognition and activati
11、on9-31. Also named CTLA-4 2. homodimer, has homology with CD28 3.On the surface of active T cells 4.Function ：inhibiting activation of T cellsCD152CD participating in T cell recognition and activation7-3CD2：T/NK; SRBCR; binding LFA-3; adhesion and activation CD3：T；transfer active signals CD4：T；recep
12、tor of HIV; binding MHC-I; adhesion and signal tranduction CD8：T；binding MHC-I; adhesion and signal tranduction CD28：T；binding B7; costimulation CD152：CTLA-4； active T；binding B7; inhibiting activationsummary7-1CD1549-2CD19：IgSF；regulating differentiation CD21：rest mature B，DC； regulating differenti
13、ation ，EBVR/CR2 CD40：TNFRSF；APC；regulating proliferation and differentiation CD79：heterodimer；matural B；signal transduction CD80/86：IgSF；APC；costimulationCD participating in B cell recognition and activation7-4CD64：FcRI；APC；high affinity；ADCC， remove IC CD32：FcR；APC; low affinity；opsonization CD16：F
14、cR；phagocyte； low affinity ；ADCC， opsonization FcRI：tetrapeptide；mast cell /basophil； high affinity ；hypersensitivity I CD23：FcR；B，MNC； low affinity ； regulating IgEIg Fc receptors7-57-6细胞黏附分子 （）Cell Adhesion Molecules Molecules mediated contact and binding between cells or between cells and extrace
15、llular matrix Play the roles in the form of receptor-ligand binding Participating in cell recognition, activation and signal transduction,as well as cell growth, differentiation and cell moving According their structure features CAM are fallen into：intergrin family, selectin family, immunoglobulin s
16、uperfamily, mucin-like molecule familycadherin familyintegrin (整合素) familymediated contact and binding between cells and extracellular matrix ；Participating in cell activation proliferation and differentiation, as well as causing inflammation herteroimer 14 kinds of subunit and 8 kinds of subunit According to
