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1、培哨普利阻断心血管疾病进程jinc最新证据0徐成斌北京大学人民医院/国ACE-/s:acontinuumofbenefits霜胡405./20命EvidqenceswithPe鄢门镜广拧AlIREGISSI3SMILE“TRACEPREAMIICoronaryE1SOLVDtreatmentV-HeFT1&ICONSENSUSEHeartfailureEndothelialdysfunctionCVRiskfactorsDistributionofACE:一-ciculatingplasma)Iocal(tissue)Acuteandshort-termeffectsLong-termeffe
2、ctscardiovasculal/local“organadaptation“renalhomeostasisrenal-independentactivationadfomDzauVhicpIniemNed155(1993)嬴醌randomised1437Completed6108Lancet2003Placeboanpualeventrate;2.4%Ess口/乏一Perindopril25坤zERRR:200%p=0.00035YEEr_Placebog人l2EE门Placebov-郢/_垩JPerindopril、亡亡巧U譬EPRIARYENDPoIEUROPAHOPEPEACEp=
3、0.0003p0.001ns目ACEInhibitor22.5口Placebo们&214.0“穴CVdeathCVdeathCVdeathM|arrestM|strokeM|revascESC2005L咤一aFavoursFavoursperindopril,placeboRRR%Previous一一国一revascularisationT77Lipidloweringdrug一一国-一16.3B-blockersESC2005DEEEEEE38lowriskE5.096asaleyi英busuoeemediumriskE9.496placsboperindoprilEUR(消)PAhighriskRRR1105E55y赡丑青145-13.5氓Eplaceboperindopri
