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1、实验研究实验研究鲁氏耶尔森菌鲁氏耶尔森菌感染感染虹鳟鱼的虹鳟鱼的进入路线及组织分布进入路线及组织分布摘要：鲁氏耶尔森菌是红口石鲈肠道疾病的病原体，它给全世界水产养殖鲑鱼行业带来了重大的损失。尽管这种疾病有很大的重要性，但是有关该疾病的现有可用的发病机制资料却很少。在这项研究中，采用不同 4 种鲁氏耶尔森氏菌株接触感染虹鳟鱼的方法来进行研究感染入口。细菌学和组织学检查发现，鲁氏耶尔森菌在内部器官迅速传播感染后，鳃中出现了大量细菌。但是，只有致病性株是能够生存和繁殖在寄主上，导致感染败血症，并在数天之后死亡。这些结果表明，鳃可能是一个重要的入口，而鲁氏耶尔森菌的致病性与免疫逃避有关。关键词：鲁氏耶
2、尔森菌 感染入口 致病性 虹鳟鱼引言鲁氏耶尔森菌病原体是耶尔森氏鼠疫杆菌肠道病或红口石鲈肠道疾病（ERM）的病原体，它给全球范围内的鲑鱼养殖造成了重大的损失。虽然感染这种病原体的情况在其他鱼类中已经有所报导，鲑鱼（尤其是虹鳟）是最容易被ERM 感染的(Furones et al. 1993)。感染可能会导致在体表和内部器官出现大出血的慢性或急性败血症。尽管 ERM 很重要，但人们对鲁氏耶尔森菌能够战胜宿主防御和引起疾病的确切致病机制却知之甚少。而鲁氏耶尔森菌株之间的不同的致病性已经有所研究记录，主要是通过腹腔和肌肉注射以及接触曝光进行的。(Davies 1991, Romalde influe
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