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1、SICENCE 新闻发布 作者：范春玲 稿号： N201302012II 型星形胶质细胞在脊髓损伤修复时的角色型星形胶质细胞在脊髓损伤修复时的角色?脊髓损伤发生后，病灶周围的骨形态发生蛋白的浓度明显升高，可以有效抑制少突胶质前体细胞向 少突胶质细胞分化，并诱导其分化为II型星形胶质细胞，但目前尚不明确II型星形胶质细胞在脊髓损 伤修复中扮演什么样的角色？为此中国中南大学湘雅医学院罗学港教授和德克萨斯大学休斯敦医学 院的曹启林领导的团队进行了一项关于研究。在相对单纯的体外培养条件下，把骨形态发生蛋白4诱 导少突胶质前体细胞分化形成的II型星形胶质细胞与脊髓背根节神经元共培养，观察脊髓背根节神经
2、元的存活及突起的生长情况。结果发现II型星形胶质细胞接触培养可增加神经元的存活率和突起长度， 但相比I型星形胶质细胞和少突胶质前体细胞，II型星形胶质细胞促进脊髓背根节神经元突起生长的能 力较弱。实验创新性探索了脊髓损伤修复过程中增生的星形胶质细胞的来源和类型，以及少突胶质 前体细胞在髓鞘再生过程中的影响因素，为脊髓损伤发生后髓鞘再形成及胶质细胞增生研究提供了 好的方向。此项研究成果发表在2014年1月第2期的中国神经再生研究（英文版） 杂志上。骨形态发生蛋白 4 诱导少突胶质前体细胞分化 7d 后，星形胶质细胞标志抗原胶质纤维酸性蛋白阳性 细胞（红色荧光）均伸出多个细长突起，很少见 2 级以
3、上分支，这与 II 型星形胶质细胞的外形相符Article: “Effect of type-2 astrocytes on the viability of dorsal root ganglion neurons and length of neuronal processes“ by Chunling Fan1, Hui Wang1, Dan Chen1, Xiaoxin Cheng2, Kun Xiong1, Xuegang Luo1, Qilin Cao2 (1 Department of Human Anatomy and Neurobiology, Xiangya School
4、of Medicine, Central South University, Changsha, Hunan Province, China; 2 The Vivian L Smith Department of Neurosurgery, UT Medical School at Houston, Houston, TX, USA)Fan CL, Wang H, Chen D, Cheng XX, Xiong K, Luo XG, Cao QL. Effect of type-2 astrocytes on the viability of dorsal root ganglion neur
5、ons and length of neuronal processes. Neural Regen Res. 2014;9(2):119-128.欲获更多资讯：Neural Regen ResSICENCE 新闻发布 作者：范春玲 稿号： N201302012Role of type-2 astrocytes on the repair of spinal cord injuryIncreasing expression of bone morphogenetic proteins at the lesion site of the central nervous system possib
6、ly induces oligodendrocyte precursor cells to differentiate into type-2 astrocytes. While the restriction of oligodendrocyte differentiation could affect remyelination, it remains poorly understood how type-2 astrocytes regulate regeneration and functional recovery. Thus, examining the effects of ty
7、pe-2 astrocytes on neuronal growth is helpful in understanding the possible influential factors of oligodendrocyte precursor cells on axonal regeneration and remyelination, and may provide insights to develop a combined therapeutic strategy. Prof. Xuegang Luo from Xiangya School of Medicine, Central
8、 South University in China and Qilin Cao from UT Medical School at Houston in USA led a relevant study. In this study, using a relatively simple culture condition in vitro, type-2 astrocytes, differentiated from oligodendrocyte precursor cells by induction with bone morphogenetic protein-4, were co-
9、cultured with dorsal root ganglion neurons. They examined the effects of type-2 astrocytes differentiated from oligodendrocyte precursor cells on the survival and growth of dorsal root ganglion neurons. Results from this study showed that co-culture with type-2 astrocytes can increase neuronal survi
10、val rate and process length. However, compared with type-1 astrocytes and oligodendrocyte precursor cells, the promotion effects of type-2 astrocytes on the growth of dorsal root ganglion neurons were weaker. These findings, published in the Neural Regeneration Research (Vol. 9, No. 2, 2014), highli
11、ght the importance of choosing the optimal cell types or the proper developmental stage of cells for treating neurological diseases. Manipulating the bone morphogenetic protein signaling in the injured area may be critical to improve the therapeutic effcacy of endogenous or grafted oligodendrocyte p
12、recursor cells.Immunofuorescence image of oligodendrocyte precursor cells after differentiation induced by bone morphogenetic protein-4. Seven days later, the bodies of the glial fbrillary acidic protein-positive cells became larger and processes became thicker. These glial fibrillary acidic protein
13、-positive cells presented many thin and long processes.Article: “Effect of type-2 astrocytes on the viability of dorsal root ganglion neurons and length of neuronal processes“ by Chunling Fan1, Hui Wang1, Dan Chen1, Xiaoxin Cheng2, Kun Xiong1, Xuegang Luo1, Qilin Cao2 (1 Department of Human Anatomy
14、and Neurobiology, Xiangya School of Medicine, Central South University, Changsha, Hunan Province, China; 2 The Vivian L Smith Department of Neurosurgery, UT Medical School at Houston, Houston, TX, USA)Fan CL, Wang H, Chen D, Cheng XX, Xiong K, Luo XG, Cao QL. Effect of type-2 astrocytes on the viability of dorsal root SICENCE 新闻发布 作者：范春玲 稿号： N201302012ganglion neurons and length of neuronal processes. Neural Regen Res. 2014;9(2):119-128.
