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1、第50卷 第2期2014年4月兰uni5DDE大学学uni62A5（uni81EA然uni79D1学版）Journal of Lanzhou University (Natural Sciences)Vol.50 No.2Apr.2014uni6587uni7AE0编uni53F7:0455-2059(2014)02-0267-12uni529Funi80FD材uni6599在药物传递uni7CFBuni7EDF中uni7684uni5E94用uni8BB8uni5FD7刚1, 彭 蕊1, uni738B东东1, uni5F90 uni53CC1, 张海霞1,21. 兰uni5DDE大学化学化
2、uni5DE5学院, 兰uni5DDE 7300002. 中uni56FDuni79D1学院兰uni5DDE化学物理研究所西北特色植物资uni6E90化学uni91CDuni70B9uni5B9Euni9A8Cuni5BA4, 兰uni5DDE 730000摘 uni8981:将uni529Funi80FD材uni6599引入到药物传递uni7CFBuni7EDF当中,uni6781大地uni63A8uni52A8uni4E86药物传递uni7CFBuni7EDF研究uni65B9向uni7684uni53D1展.uni91CDuni70B9uni4ECBuni7ECDuni529Funi80
3、FD材uni6599在药物传递uni7CFBuni7EDF中uni7684uni5E94用uni73B0uni72B6,并总uni7ED3uni4E86药物传递uni7CFBuni7EDFuni7684uni53D1展uni8D8Buni52BF.关键uni8BCD:uni529Funi80FD材uni6599;药物传递uni7CFBuni7EDF;uni4ECB孔材uni6599;uni78C1性材uni6599;uni91CF子uni70B9材uni6599中uni56FE分类uni53F7: R943 uni6587献标uni8BC6码: AApplication of function
4、al materials in drug delivery systemsXU Zhi-gang1, PENG Rui1, WANG Dong-dong1, XU Shuang1, ZHANG Hai-xia1,21. School of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China2. Key Laboratory of Chemistry of Northwestern Plant Resources, Lanzhou Institute of Chemical Physics,C
5、hinese Academy of Sciences, Lanzhou 730000, ChinaAbstract: In recent years, studies in functional materials have obtained compelling achievements which areunderpinned by the latest advancement in physical, chemical, biomedical and engineering sciences throughthe efforts of multidisciplinary research
6、 teams. Functional materials play a very important role in the fieldof biomedical application. Researchers have also brought functional materials into the field of drug deliverysystems, which has greatly promoted the development of drug delivery systems. In this paper the currentdevelopments in the
7、application of functional materials in drug delivery systems and the development trendswere comprehensively reviewed.Key words: functional material; drug delivery system; mesoporous material; magnetic material; quantum dotsmaterial药物传递uni7CFBuni7EDF通uni8FC7uni63A7制药物uni7684降uni89E3uni548C吸收速uni5EA6来
8、uni63D0uni9AD8药物uni7684生物利用uni7387, 同uni65F6通uni8FC7靶向uni7EC6uni80DE等降低医uni7597uni8FC7程中药物uni7684副作用. uni529Funi80FD材uni6599作为一uni95E8uni7ED3合多uni95E8学uni79D1优uni70B9uni7684uni65B0兴专业, 由uni4E8Euni81EAuni8EABuni529Funi80FDuni7684uni53EFuni8BBEuni8BA1uni548C多样化, 使uni5F97其在物理、化学uni53CA生物医学等uni9886uni57
9、DF中有着广uni6CDBuni7684uni5E94用. uni8FD1年来, 研究uni4EBA员先后制备uni51FA一uni7CFB列uni7684uni529Funi80FD材uni6599, 并将其uni5E94用到药物传递uni7CFBuni7EDF当中, 期uni5F85降低uni76EE标药物uni7684副作用. 本uni6587分类uni4ECBuni7ECDuni4E86uni4ECB孔材uni6599、Magnetic nanopar-ticles(MNPs)、uni91CF子uni70B9(Quantum dots, QDs )uni548C聚合物材uni6599等
10、uni529Funi80FD材uni6599在药物传递uni7CFBuni7EDF中uni7684uni5E94用uni73B0uni72B6,并总uni7ED3uni4E86药物传递uni7CFBuni7EDFuni7684uni53D1展uni8D8Buni52BF.1 uni4ECB孔材uni6599uni81EA1992年Beck等1uni9996次合成uni51FA有uni5E8Funi4ECB孔材uni6599M41Suni4EE5来, uni4ECB孔材uni6599就uni51ED借稳uni5B9Auni7684物理uni548C化学性质、uni9AD8uni6BD4表面uni
11、79EF、uni9AD8吸附性uni80FD、表面易uni529Funi80FD化uni548C良好uni7684生物兼uni5BB9性等优uni70B9先后uni88ABuni79D1学uni5BB6uni4EEC广uni6CDBuni5E94用到uni50AC化、分uni79BB、uni7EB3米生物医学, 尤其是药物传递uni7CFBuni7EDF等uni9886uni57DF中23. uni56FE1显示uni7684是uni4ECB孔材uni6599在生物医学uni9886uni57DF中uni7684uni5E94用2.研究uni4EBA员将uni4ECB孔材uni6599用uni
12、4E8E药物传递uni7CFBuni7EDFuni5E94用当中, 主uni8981考虑uni4EE5下两uni70B9: 1) uni4ECB孔材uni6599是一类物理化学性质稳uni5B9A, 低uni6BD2且生物兼uni5BB9性好uni7684生物材uni6599;收稿uni65E5期:2013-05-06; uni4FEEuni56DEuni65E5期: 2013-05-30uni57FAuni91D1项uni76EE:中uni56FDuni79D1学院西北特色植物资uni6E90化学uni91CDuni70B9uni5B9Euni9A8Cuni5BA4开放uni8BFEuni9
13、898项uni76EE(CNPR-2012kfkt-10)作者uni7B80uni4ECB:uni8BB8uni5FD7刚(1985), 男, uni6CB3南漯uni6CB3uni4EBA, 博uni58EB研究生, e-mail: , 研究uni65B9向为uni65B0uni578B药物传递uni7CFBuni7EDFuni7684合成;张海霞(1970), 女, uni6CB3北uni90A2uni53F0uni4EBA, 教uni6388, 博uni58EB研究生uni5BFC师, 博uni58EB, e-mail: , 研究uni65B9向为uni529Funi80FD材uni65
14、99与分uni6790化学,通uni4FE1联uni7CFBuni4EBA.268 兰uni5DDE大学学uni62A5（uni81EA然uni79D1学版） 第50卷2) uni4ECB孔材uni6599uni62E5有均匀uni7684孔道uni4ECB孔, 且其uni5185、外表面uni90FD含有大uni91CFuni7684硅uni7F9Funi57FA, uni5F88uni5BB9易uni4FEE饰具有特uni5B9Auni529Funi80FDuni7684uni57FAuni56E2分子. 药物uni548Cuni529Funi80FD化uni4ECB孔材uni6599un
15、i53EFuni4EE5通uni8FC7表面uni7684uni79BB子键uni548C氢键等作用uni529B形成主(uni4ECB孔材uni6599)uni5BA2(药物)复合材uni6599. 药物uni548Cuni4ECB孔材uni6599之uni95F4uni7684作用uni529B一uni65B9面uni53EFuni4EE5uni5B9Euni73B0药物uni7684缓uni91CA, 降低药物在传递uni8FC7程中uni7684uni6CC4漏; uni53E6一uni65B9面, uni8BE5主uni5BA2复合材uni6599也uni53EF通uni8FC7靶向
16、分子uni5B9Euni73B0药物uni7684靶向传递uni548Cuni91CA放. uni4ECB孔材uni6599uni7684上uni8FF0优uni70B9使uni5F97其成为一类非常有潜uni529Buni7684药物传递平uni53F0.uni56FE 1 uni4ECB孔材uni6599在生物医学uni9886uni57DF中uni7684uni5E94用Figure 1 The biomedical application of mesoporoussilica materialsuni6587献4将氨uni57FAuni5B98uni80FDuni56E2uni4FEE饰到uni4ECB孔材uni6599SBA-15uni5185表面, 并将CdSQDs引入到uni4ECB孔材uni6599uni7684uni5185uni90E8孔道中, 将其用uni4E8E药物布洛uni82ACuni7684传递. 氨uni57FAuni57FAuni56E2不uni4
