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1、NIH Proposal OutlineTwelve Page Limit For Activity Codes R01, R10, R15, R18, R21/R33, R24, R33, R34, DP3, G08, G11, G13, SC1, X011. Introduction to Application (for Resubmission or Revision applications only) LIMITED TO 1 PAGE For resubmissions, the introduction should summarize the substantial addi
2、tions, deletions, and changes to the application. The Introduction must also include a response to the issues and criticism raised in the Summary Statement. For revisions, the introduction should describe the nature of the supplement and how it will influence the specific aims, research design, and
3、methods supported by the current award.2. Specific Aims LIMITED TO 1 PAGE State concisely the goals of the proposed research and summarize the expected outcomes, including the impact that the results of the proposed research will exert on the field involved. List succinctly the specific aims of the
4、research proposed (e.g., to test a stated hypothesis, create a novel design, solve a specific problem, challenge an existing paradigm or clinical practice, address a critical barrier to progress in the field, or develop new technology).3. Research Strategy LIMITED TO 12 PAGES (sections a-c) Organize
5、 the Research Strategy in the order specified below. Start each section with the appropriate section heading Significance, Innovation, Approach. Cite published experimental details in the Research Strategy section and provide the full reference in the Bibliography and References Cited section. (a) S
6、ignificance Suggested length 2-3 pages Explain the importance of the problem or critical barrier to progress in the field that the proposed project addresses. Explain how the proposed project will improve scientific knowledge, technical capability, and/or clinical practice in one or more broad field
7、s. Describe how the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field will be changed if the proposed aims are achieved.(b) Innovation Suggested length 1-2 page Explain how the application challenges and seeks to shift current research or clin
8、ical practice paradigms. Describe any novel theoretical concepts, approaches or methodologies, instrumentation or interventions to be developed or used, and any advantage over existing methodologies, instrumentation, or interventions. Explain any refinements, improvements, or new applications of the
9、oretical concepts, approaches or methodologies, instrumentation, or interventions.(c) Approach Suggested length 7-9 pages Describe the overall strategy, methodology, and analyses to be used to accomplish the specific aims of the project. Include how the data will be collected, analyzed, and interpre
10、ted, and any resource sharing plans as appropriate, unless addressed separately in Item 15 (Resource Sharing Plan). Discuss potential problems, alternative strategies, and benchmarks for success anticipated to achieve the aims. You also may wish to include a discussion of future directions for your
11、research, as well as a project timeline, in this section. If the project is in the early stages of development, describe any strategy to establish feasibility, and address the management of any high risk aspects of the proposed work. Point out any procedures, situations, or materials that may be haz
12、ardous to personnel and precautions to be exercised. A full discussion on the use of Select Agents should appear in Item 11, below. Preliminary Studies for New Applications: For new applications, include information on Preliminary Studies as part of the Approach section. Discuss the PD/PIs prelimina
13、ry studies, data, and or experience pertinent to this application. Except for Exploratory/Developmental Grants (R21/R33), Small Research Grants (R03), and Academic Research Enhancement Award (AREA) Grants (R15), preliminary data can be an essential part of a research grant application and help to es
14、tablish the likelihood of success of the proposed project. Early Stage Investigators should include preliminary data (however, for R01 applications, reviewers will be instructed to place less emphasis on the preliminary data in application from Early Stage Investigators than on the preliminary data
15、in applications from more established investigators). Progress Report for Renewal and Revision Applications. For renewal/revision applications, provide a Progress Report as part of the Approach section. Provide the beginning and ending dates for the period covered since the last competitive review.
16、Summarize the specific aims of the previous project period and the importance of the findings, and emphasize the progress made toward their achievement. Explain any significant changes to the specific aims and any new directions including changes to the specific aims and any new directions including changes resulting from significant budget reductions. A list of publications, patents, and other printed materials should be included in Item 5 (Progress Rep
