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1、学科代码 03b小细胞肺癌临床特征与治疗疗效相关性研究丁翠敏 ，郑辉辉河北医科大学第四医院，呼吸内科,056000【摘要】目的：本研究将从小细胞肺癌（SCLC）患者的临床特征等方面着手分析其与 SCLC 一线治疗中位无进展生存期（PFS）的关系，进而为探讨小细胞肺癌的预后因素和延长生存提供依据。方法：收集 2006 年 2 月至 2013 年4 月就诊于我院呼吸内科，并证实为小细胞肺癌患者，按要求记录患者的临床资料。对 52 例 SCLC 患者进行随访，并计算一线治疗的中位 PFS，并分析其与患者临床特征、治疗前血清钠、NSE 水平及放疗时机的关系。采用 Mann-Whitney U 非参数秩
2、和检验比较不同临床特征的患者一线治疗的 PFS 的差异，P0.05 表示差异有统计学意义。结果：1 本研究中男性患者 39 例，占 75%，女性患者 13 例，占 25%；16.3ng/ml in 36 cases, accounted for 97.3%, 95ng/ml in 9 cases, accounted for 24.3%; after the 2 cycle of chemotherapy return to normal is 15 cases, accounted for 60%, 10 cases of NSE is 16.3ng/ml, accounted for 40
3、%.Three cycles of chemotherapy to radiotherapy is defined as early radiotherapy, a total of 10 cases (58.8%), and chemotherapy cycle after three cycles and 3 radiations is defined as late radiation, a total of 7 cases, accounting for 41.2%.2 male patients with 39 cases, including a PFS for 7 months,
4、 13 cases of female patients, including a PFS for 10 months, P=0.022;29 cases of patients with 0.05.Conclusions：1 this study shows that age, smoking status, sodium levels before treatment with PFS of first-line treatment of small cell lung cancer is independent.2 NSE levels before treatment with PFS
5、 of first-line treatment of small cell lung cancer-related, NSE95ng/ml is significantly better than NSE 95ng / ml .3 Sex is predictor of PFS the first-line treatment of SCLC patients female patients is significantly better than male patients.4 Clinical stages is a predictor of SCLC patients treated
6、first-line PFS, for limited stage was significantly better than extensive stage .5 The PFS of early radiotherapy has a tendency to extend comparing the PFS of late radiotherapy.Keywords:SCLC;clinical characteristics; sodiumlevel ; NSE ; radiotherapy ; 报告作者地址：河北医科大学第四医院呼吸内科电话：13933083069 电子邮箱：身份证号码：130103196401160920
