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1、Dear Editor,We would like to submit the enclosed manuscript entitled GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons, which we wish to be considered for publication in Nature Neuroscience. GDNF has long been thought to be a potent neurotrop
2、hic factor for the survival of midbrain dopaminergic neurons, which are degenerated in Parkinsons disease. In this paper, we report an unexpected, acute effect of GDNF on A-type potassium channels, leading to a potentiation of neuronal excitability, in the dopaminergic neurons in culture as well as
3、in adult brain slices. Further, we show that GDNF regulates the K+ channels through a mechanism that involves activation of MAP kinase. Thus, this study has revealed, for the first time, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survi
4、val factor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is to regulate neuronal excitability, and consequently dopamine release. These results may also have implications in the treatment of Parkinsons disease. Due to a direct competition and conflict of interest, w
5、e request that Drs. XXX of Harvard Univ., and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I am Sincerely yours,case2Dear Editor,We would like to submit the enclosed manuscript entitled Ca2+-binding protein frequenin mediates GDNF-induced potentiation of Ca2+
6、channels and transmitter release, which we wish to be considered for publication in Neuron. We believe that two aspects of this manuscript will make it interesting to general readers of Neuron. First, we report that GDNF has a long-term regulatory effect on neurotransmitter release at the neuromuscu
7、lar synapses. This provides the first physiological evidence for a role of this new family of neurotrophic factors in functional synaptic transmission. Second, we show that the GDNF effect is mediated by enhancing the expression of the Ca2+-binding protein frequenin. Further, GDNF and frequenin faci
8、litate synaptic transmission by enhancing Ca2+ channel activity, leading to an enhancement of Ca2+ influx. Thus, this study has identified, for the first time, a molecular target that mediates the long-term, synaptic action of a neurotrophic factor. Our findings may also have general implications in
9、 the cell biology of neurotransmitter release.0630投稿写作 某杂志给出的标准 Sample Cover Letterthe example used is the IJEBCase 3Sample Cover Letterthe example used is the IJEB Dear Editor of the please type in journal title or acronym: Enclosed is a paper, entitled Mobile Agents for Network Management. Please
10、accept it as a candidate for publication in the journal title. Below are our responses to your submission requirements. 1. Title and the central theme of the article. Paper title: Mobile Agents for Network Management. This study reviews the concepts of mobile agents and distributed network managemen
11、t system. It proposes a mobile agent-based implementation framework and creates a prototype system to demonstrate the superior performance of a mobile agent-based network over the conventional client-server architecture in a large network environment.2. Which subject/theme of the Journal the materia
12、l fits New enabling technologies (if no matching subject/theme, enter Subject highly related to subject of journal but not listed by please type in journal title or acronym) 3. Why the material is important in its field and why the material should be published in please type in journal title or acro
13、nym? The necessity of having an effective computer network is rapidly growing alongside the implementation of information technology. Finding an appropriate network management system has become increasingly important todays distributed environment. However, the conventional centralized architecture,
14、 which routinely requests the status information of local units by the central server, is not sufficient to manage the growing requests. Recently, a new framework that uses mobile agent technology to assist the distributed management has emerged. The mobile agent reduces network traffic, distributes
15、 management tasks, and improves operational performance. Given todays bandwidth demand over the Internet, it is important for the journal title/acronym readers to understand this technology and its benefits. This study gives a real-life example of how to use mobile agents for distributed network man
16、agement. It is the first in the literature that reports the analysis of network performance based on an operational prototype of mobile agent-based distributed network. We strongly believe the contribution of this study warrants its publication in the journal title/acronym.4. Names, addresses, and email addresses of four expert referees. Prof. Dr. William Gates Chair Professor of Information Technology 321 Johnson Hall Premier University Lancaster, NY 0001
