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1、90.19. Wang ZG, et al. Asian J Surg 1999; 22:169- 173.20. Miyata T, et al. J Vasc Surg 1998;27: 438- 445. 21. Sarkar R, et al. Surg 1991;109: 143- 148.22. Wassermann K, et al. Respira-tion1988; 53: 91- 110.23. Robbs JV, et al. Eur JVasc Surg 1994; 8: 401.24. Ando M, et al. J VascSurg 2000; 31: 1042-
2、 1045.25. Van den AkkerPJ, et al. Ann Surg 1989; 210: 658- 666.26. Ku-mar S, et al. ClinRadiol 1990; 42: 342- 347. 5 = 3 y 0 k (文献综述)(第四军医大学唐都医院胸腔外科,西安710038谷仲平综述王云杰审校)4 1 k 3 a M 5 = 3 y 0 (VEGF) 5 3 M 1 , 5 M k b VEGF s 0 + a ? k T T B 8 b1 o M 5 = 3 y 0 5 k m s | :R734;Q7 D S M :A cI | :1000- 687
3、7(2002)04- 0232- 03 5 3 * L 8 ? , 5 - ?(prevascular stage) Y V Z T | ! ,N ? l 0.4 mm3,% V 107, 9 3 ? b ? v 0.4 mm3H , Z T X ? 3 1 , ? 5 (vascular stage),7 S 1 & 5 d ,3 F (1)b 5 3 s y 0 , 5 = 3 y 0 (vascular endothelial growth factor, VEGF) T K E VEGF VEGFR ,V 7 E VEGF % 9 s b T $ ? V V rVEGF7 h , sF
4、lt-1V e 5 3 bTakayama (19) k % H157y ? , F h 8 IgG Fc V VEGFs 8 sFlt-1 ,10? ,? v l ,F _ A U ? 5 s A , ? % A 9 F b4 U F h VEGFV s 8 ? r ? 3 ,9 F b7 3 p53 y ? % 9 ,i / = VEGF mRNA VEGF 0 bp53 y l M ,| VEGFV r ,9 F 3 5 , ? ? Z bNishizaki (20)Y V F h 73 p53 y CAdCMV p53 d l % k % H226Br,? C V A VEGF V r
5、 ,i % 8 = k M ,P ? 5 b6 ,c-mycaras VHL(Von Hipel-Landau) yl M 9 VEGF V r , ? 3 5 9 F (21,22)bv-Src y V V r V VEGF 0 , 9 FVEGFV r ,7 3 p53 y i H ,v-Src ? VEGF 0 cb (ribozyme) RNAs 0 ,V + s M RNAs 0 , Q l RNAM 1 , mRNA ? ,7 O M mRNA ? ,y 7 r q bOshika (23)| A 0 6; h d l % k % OZ-6/VR, TVEGF mRNA s A ,
6、| OZ-6/VR% 1105/ 8 = , B ? ,7 v F 8 = ? bPavco (24) ? 3 M Lewis k P Flt-1(VEGFR-1) , ? 3 M s A b5. Y V VEGF7 r F ? 5 k B 5 , - ) L , X | 7 T b . d ? % M 1 , 3 0 0 a s ? % K a+ s 7 r ; F ? 5 A ,7 V ? Y g o M b6 ,F 5 2 _ 5 9 z % b ? 5 ,M - i 5 B % ,F ? 5 | k 1 m b参考文献1. Carmeliet P, et al. Nature 2000
7、; 407(6801):249- 257.2. Shibuya M. Cell Struct Funct 2001;26(1): 25- 35.3. Ferrara N, et al. Biochem Bio-phys Res Commun 1989; 161(2): 851- 858. 4.Senger DR, et al. Science 1983; 219(4587): 983-985.5. Hyder SM, et al. Cancer Res1998; 58(3):392- 395.6. Ferrara N. Am J Physiol Cell Physiol2001; 280(6)
8、: C1358- C1366.7. Neufeld G, et al.FASEBJ 1999; 13(1): 9- 22.8. Salven P, et al.Am J Pathol 1998; 153(1): 103- 108.9. GerberHP, et al. J Biol Chem 1998; 273(46): 30336-30343.10. Bates DO, et al. J Physiol 2001; 533(Pt1): 263- 272.11. Rousseau S, et al. Trends Car-diovasc Med 2000; 10(8): 321- 327. 1
9、2. PepperMS, et al. Exp Cell Res 1994; 210(2): 298- 305.13. Laughner E, et al. Mol Cell Biol 2001; 21(12):3995- 4004.14. Imoto H, et al. J Thorac Cardio-vasc Surg 1998; 115(5): 1007- 1014. 15. VolmM, et al. Anticancer Res 1999; 19(1B): 651- 655.16. Chandrachud LM, et al. Br J Cancer 1997; 76(10): 1367- 1375.17. Brekken RA, et al. CancerRes 2000; 60(18): 5117- 5124.18. Nguyen JT, etal. Cancer Res 1998; 58(24): 5673- 5677. 19.Takayama K, et al. Cancer Res 2000; 60(8): 2169-2177. 20. Nishizaki
