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1、1Adrenomedullin diagnosis of tuberculosis and pneumonia and to identify the value ofAuthor: the Chunling Jiangling Zhi Li Li Wangying years Liurui Zhen Zhang Jianjun Keywords: adrenal Abstract Objective To investigate the adrenomedullin (AM diagnosis of tuberculosis and pneumonia and to identify, pr
2、ovide a new reliable theoretical basis for early clinical identification of tuberculosis and pneumonia, tuberculosis and pneumonia patients and normal control group. Method were detected by radioimmunoassay of AM content in the plasma were analyzed statistically using analysis of variance results of
3、 tuberculosis and pneumonia patients plasma AM was higher than normal control group (F = 30.66, q = 11.01,4.44, P 0.05, tuberculosis patients plasma AM content was significantly higher than pneumonia patients (q = 6.57, P 0.05. Conclusion AM can be used as early differential diagnosis of pulmonary t
4、uberculosis and pneumonia, laboratory parameters. Keywords: adrenomedullin; tuberculosis, lung; 2pneumonia; diagnosis ABSTRACT ObjectiveTo explore the value and clinical significance of adrenomedullin (AM) in differential diagnosis between lung tuberculosis and pneumonia, and to provide a new theore
5、tical basis for early diagnosis of the diseases.MethodsThe concentration of AM in plasma was measured in 90 persons including patients with lung tuberculosis, pneumonia and normal controls by radioimmunoassay (RIA) method, and the result was analyzed statistically. ResultsThe level of AM in plasma o
6、f patients with pulmonary tuberculosis and pneumonia was higher than that of normal controls, the difference was significant (F = 30.66; q = 11.01,4.44; P 0.05), and it showed significantly higher in lung tuberculosis patients compared with pneumonia ones (q = 6.57, P 0.05). ConclusionAM detection c
7、an be used as a laboratory parameter in early differential diagnosis between pulmonary tuberculosis and pneumonia. KEY WORDS adrenomedullin, pulmonary tuberculosis, pneumonia, diagnosis The incidence of tuberculosis and pneumonia is still high, both clinical symptoms and chest X-ray and CT 3findings
8、 are sometimes difficult to identify how the early differential diagnosis of pulmonary tuberculosis and pneumonia, has been troubled by the problem of clinicians, we studied the adrenal medullary the value of quality (AM both differential diagnosis, clinical differential diagnosis in order to provid
9、e a reliable laboratory evidence. 1 Materials and Methods 1.1 General Information Select 30 cases of pneumonia, 30 cases of tuberculosis patients and 30 cases of health checkup by 30 cases of pneumonia, 15 cases of tuberculosis patients and 30 healthy subjects from Qingdao Central Hospital in Septem
10、ber 2003 in-patients and healthy subjects, 15 cases of tuberculosis patients from the Chest Hospital of Qingdao City in September 2003 in-patients. 16 cases of tuberculosis patients male and 14 female; age 25 to 67 years, median age 49 years old. Pneumonia patients, 18 males, 12 females, aged 28 to
11、65 years of age, median age 50 years old. Healthy subjects 17 cases of male and 13 females, aged from 25 to 67 years, median age 49 years. 41.2 Reagents and apparatus Radioimmunoassay kits in the AM, EDTA reagent, aprotinin by the PLA Navy, RIA Technology Center. The DFM96 type radioimmunoassay coun
12、ter by Hebei instrumentarija production. 1.3 Methodology With 5 mL disposable sterile needle to extract subjects venous blood 2 mL injection containing 0.5 mol / L, EDTA2Na 20 L of aprotinin 50 L of the test tube, 2 500 r / min centrifugation for 15 min, and plasma in strict accordance with AM reage
13、nt box manual detection of AM content. 1.4 statistical treatment The experimental data with +-s, using the SSPS 10.0 software for statistical analysis. 2 results 2.1 the AM content The AM content of peripheral blood plasma of tuberculosis, pneumonia, and normal control group were (67.87 + -14.87) (5
14、2.69 + -10.20) and (42.43 + -12.47) ng / L, tuberculosis, pneumonia plasma AM content were higher than The normal control group, the difference was 5significant (F = 30.66, q = 11.01,4.44, P 0.05, tuberculosis group patients plasma AM levels higher than the pneumonia group, the difference was signif
15、icant (q = 6.57, P 0.05. 2.2 the AM sensitivity and specificity for the diagnosis of pulmonary tuberculosis The receiver operating characteristic (ROC) analysis showed that AM 63.26 ng / L is the critical value, the diagnosis of tuberculosis sensitivity and specificity were 66.7% and 90.0%, accuracy
16、 82.2%. Share in the free paper download center http:/3 to discuss Clinical manifestations of tuberculosis and pneumonia and chest X-ray and CT findings are sometimes not typical in the early confusing and could easily lead to misdiagnosis and delay in treatment can be caused by medical disputes. For early identification of tuberculosis and pneumonia clinicians popular concern in this study shows that tuberculosis and pneumonia in plasma AM le
