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1、1Acute cerebral infarction in patients with glycosylated hemoglobin testing AnalysisAbstract Objective To investigate the acute cerebral infarction in patients with glycosylated hemoglobin test results and analysis of its clinical significance. Methods A retrospective analysis of 92 cases of acute c
2、erebral infarction treated in our hospital in May 2008 to September 2010, glycosylated hemoglobin (HB A1c test results which non-diabetic patients of 50 cases of acute cerebral infarction, acute cerebral infarction in diabetic patients with 42 cases and two sets of test results were analyzed the res
3、ults of acute cerebral infarction with diabetes mellitus group HBA1c levels of acute cerebral infarction was significantly higher than non-diabetic group. two groups compared significant difference (P 0.05. conclusion glycosylated hemoglobin (HB A1c) testing is an effective identification of diabeti
4、c and non diabetic cerebral infarction, sensitive and precise clinical indicators. Keywords: acute cerebral infarction, 2glycosylated hemoglobin, diabetes Patients with acute cerebral infarction is often accompanied by elevated blood sugar and diabetes as risk factors for acute cerebral infarction h
5、as formed a consensus 1 plays a very important clinical role of glycosylated hemoglobin testing in the diagnosis, treatment and prognosis of diabetes. I intended to explore glycosylated hemoglobin in the differential diagnosis of acute cerebral infarction for emergency blood glucose increased, or it
6、self, the clinical significance of concurrent diabetes are reported below. 1 Materials and Methods 1.1 General Information May 2008 to September 2010 the Fourth Peoples Hospital of Xinxiang City, admitted to acute cerebral infarction (ACI patients, 92 cases, including 56 males and 40 females aged 41
7、 to 80 years 42 cases of acute cerebral infarction with diabetes group, non-diabetic group of 50 cases of acute cerebral infarction. all patients with cerebral infarction are in line with cerebrovascular disease diagnostic criteria developed by the 1995 Fourth National Cerebrovascular Disease 3Confe
8、rence in all cases by CT and MRI confirmed that all patients with cerebral infarction are the first hair. the diagnostic criteria of diabetic patients are in line with the 1999 WHO diagnostic criteria for diabetes. 1.2 Methods 1.2.1 The experimental methods The two groups were collected at onset of
9、24 h fasting blood 2 ml of fasting blood glucose using the oxidase method automatic biochemical analyzer testing, glycosylated hemoglobin using high performance liquid chromatography kit and a variety of technical indicators are in line with requirements. 1.2.2 The statistical methods The experiment
10、al data SPSS11.0 software package, the results of a +-s between the two groups were compared using the t test, P 0.05, two sets of 4glycosylated hemoglobin levels compared with diabetic group was significantly higher than non-diabetic group, P 0.05, Table 1. Table 1, two groups of fasting blood gluc
11、ose and glycosylated hemoglobin test results compare Group n glycosylated hemoglobin (% of fasting blood glucose (mmol / L ACI non-diabetic group 507.68 + -1.088.34 + -2.13 ACI with diabetes group 425.27 + -1.028.52 + -2.29 P = P 0.05 P values P 0.05 Links in the free paper download center http:/3 t
12、o discuss Diabetes is 2 to 3 times the prevalence rate of diabetes, cerebral infarction an independent risk factor for diabetic patients with cerebral infarction 2. HB A1c hemoglobin and glucose in the blood the formation of a continuous non-enzymatic reaction complex, and its content depends on the
13、 blood glucose concentration because the average life span of red blood cell is about 120 days, so he can reflect the average of two to three months in the pre-test blood glucose, regardless of the 5temporary fluctuations of blood glucose concentration. When the long-term control of blood sugar in d
14、iabetics is not ideal, sustained high blood sugar can make hemoglobin glycosylation occurs, then reduce the oxygen and hemoglobin dissociation rate, resulting in tissue hypoxia and the longevity of protein non-enzymatic glycosylation, generate advanced glycation end products (AGEs) 3 Many studies ha
15、ve shown a close relationship between 4 5, in vivo AGEs build sets and atherosclerosis: in the vessel wall deposition to act on the endothelial extracellular matrix, stimulate irreversible cross-linking collagen leading to stromal hyperplasia caused by vascular wall thickening, stenosis, vascular diastolic dysfunction. in order to initiate and accelerate the development of atherosclerosis and promote thrombosis. diabetes easy to cerebral infarction, the crown one of the main reasons for heart disease an
