《ORION Abstract - Infectious Disease Research Network猎户座摘要传染病研究网络》由会员分享，可在线阅读，更多相关《ORION Abstract - Infectious Disease Research Network猎户座摘要传染病研究网络（26页珍藏版）》请在金锄头文库上搜索。
1、.,Making research J Antimicrob Chemother 2007 www.idrn.org/orion.php,.,Co-authors Cooper et al BMJ 2004,Cochrane review of interventions to change antibiotic prescription Ramsay et al JAC 2003,Studies conclude interventions cause MRSA or antibiotic use or Clostridium difficile Validity of conclusion
2、s threatened by confounders OR),.,The sort of problems: regression to mean, statistical analysis,Onesko KM, Infection Control 1987,Non-medicated soap,Low-iodine soap,.,Interrupted time series,.,AIM OF ORION StatementCONSORT equivalent for infection control studies,Improve standards research JAC 2007
3、;www.idrn.org/orion.php,22 item checklist Title Abstract Introduction Methods Results Discussion Summary table Population Clinical setting Precise nature & timing of all interventions Graphical summary results,adapted CONSORT statement to the wide variety settings interventions, designs & statistica
4、l issues infection control studies & outbreak reports Consultation with professional societies Independent academic review in two journals,.,ORION exemplar paper. .Fowler S et al JAC 2007,.,CONSORT journal & conference abstract checklistHopewell et al PLOS Med 2008,ORION is a CONSORT equivalent for
5、Infection Control and Antimicrobial Stewardship interventions & Outbreak Reports CONSORT for ABSRACTS : for submission & review of conference & journal abstracts of RCTs (same flaws as full articles) Aim to improve reporting of RCTs in journal abstracts & conference proceedings, giving readers the d
6、etail & clarity to assess validity & applicability of RCT and help them decide which full articles to read or conference presentations to attend ORION followed suit Used for SHEA Conference 2011,.,SUBMISSION & REVIEWERS ABSTRACT CHECKLIST FOR INTERVENTION STUDIES AND OUTBREAK REPORTS,.,ABSTRACT CHEC
7、KLIST (cont),.,Stone et al abstract,Title- not explicit that intervention study Background- rationale but no clear hypothesis Methods- design: not stated Brief description of intervention but not setting, participants or dates Outcomes- (I) no regular time intervals ie not disaggregated (ii) clear C
8、DI outcomes but not AB,Statistical analysis: fail to account for dependencies (segmental regression for AB & Poisson for CDI) Confounders/bias - no mention Culture, typing etc - N/R Results- no estimated size effect & precision, no graphical summary Conclusions- no original hypothesis . ,.,P1381 Fee
9、dback Intervention Trial (poster this afternoon),Title- RCT Background- rationale but no explicit hypothesis + Methods- -design: clear -setting, participants, intervention, dates Outcomes- - clear primary & secondary -regular time points (monthly- fig) - clear denominators ,Statistical analysis: acc
10、ounts for dependencies Confounders/bias - mentioned & accounted for Culture, typing etc- N/R Results- estimated size effect & precision, graphical summary Conclusions- no explicit hypothesis but accounted for confounders (implementation) . +,.,Outbreak abstract 1Lopansri et al HPA SHEA 2010,Title: o
11、utbreak report Background: rationale and objectives Methods- -case definition -no outbreak definition -hospital setting & outbreak control measures but not ward briefly described but little detail on participants + - start & stop dates for original index cases but not for whole study + - outcomes &
12、stat analysis : NR,Methods (cont)- -Risk factors analysed but are there others that should be mentioned as not having been present + More details on micro/strain? Information on C&S from samples from flash sterilised equipment? Results- -OK but graph might have been helpful- Conclusions- - Clinical
13、significance observation & explanatory hypothesis ,.,Outbreak abstract 2Marchaim D et al SHEA 2010,Title: outbreak in title Background: rationale and objective Methods- -clear case definition -participants settings & outbreak control measures not described but LOS, age, mortality given - start & sto
14、p dates of outbreak given but not of study + - outcomes: chart would have been useful especially as shared wards presented as important ,Methods (cont)- - stats:NR -Confounders:NR -Cultures etc : other risk factors (eg patients characteristics, environmental contamination) not mentioned Results- -ch
15、art would have been useful -colistin agrregated Conclusions- - Significance not stated. No hypothesis generated. Effect of control measures stated with no evidence,.,Reflections 1,Has the session achieved its original aims? 1. Helping you write high quality conference or journal abstracts 2.Providin
16、g you with a framework to help referee a conference abstract 3.Helping inform your CPD with a tool to help select -which full articles to read -which conference sessions to hear Was this appropriate for a “meet the expert” session? Tool and meet the expert session materials is on website www.idrn.org/orion.php,.,Reflections 2,Did ORION for abstracts work for intervention studies? Did ORION for abstracts work in outbreak reports? Does it need an explanatory document like CONSORT with examples of
