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1、l%VS#fil陈蕴颖步宏综述李幼平审校(华西医科大学附属第一医院移植免疫实验室,成都610041)=K1l%( DC)fs1f%,8=M+,#dDCfsT。8DCVS,Os0Vr#fil8!ZEZKZ,DCB。1oMl%VSOs08!Surface Phenotype on Dendritic Cells andtheir Immunological SignificanceChen YunyingBuHongLi Youping( Transplantation Immunology Laboratory, The First Hospital ,West China University
2、 of Medical Sciences, Chengdu 610041)Abstract Dendritic cells ( DC) are very important antigen presenting cells( APC) in immune re-sponse. DC gradually gets mature while it migrates in vivo. Compared with mature DC, immature DCplays a different rolein immune response. In this review, the recent adva
3、nces in researches on specificcell surface marker and costimulatory molecules on DC as well as their immunological significance andmethodology of propagation in vitro are discussed. It may be beneficial for further study of DC.Key words Dendritic cell Surface marker Costimulatory MoleculePropagation
4、 in vitro1-l%(Dendritic Cell, DC) d%B8。8=M+,M&87。DC1,M LRQ+$h6。4Uts0CD83+ DCfQTEslOs0。DC?p#Os0Vr?pT,VzT%|O5,APCOs0“vSc”。X+sT%,V4FCD83Vr,DC22。Flt3+M?C%y0,s8EB。VrKCD34+/C、%V, Flt38FLVrvF2%V, Flt3FLV*/%9s。 Maraskovsky,GM-CSF8DC!V%y0,8=DC9, FLTv,7GM-CSFiV。FLl,Vl2(%d%2)DC923。-DC8!9Flt3/FL3,lFV,CD34+ -8%!
5、,FFLVA9FDC24, 25。BL8%!FFBS(ldb),7DC!EPFBS,y!VDCV?sEFQ,.V?L!95X1Q。!Bn5V!DCZE%1,yN!%DCkYs1。!%l%kY-T,|“”Q|l%,%!-LC373+|s,q。VBsXCD83DC+Ss0,7%PV!9CD83Vr。yN|FCD83XHF8( HB-15a),f;E,T%N|CD83+%s,qr99% 8, 9, 22。CD83+ DC%6B)iVrvFC8s8,CD35( CRI)、CD21( CR2)、 CD11b ( CR3)、 CD64( FCRI)、CD16( FCR )CD23( FCR ),VrCD3
6、2( FCR )。5CD83+TDC+Ss0|DCMYs,Bt%?s0+。bDC?s0+, DC?p,DC8!ZE,|Llz。9, DCfs1?%,DCVS4123D15#filZ,|Df5?Z。ID1 ODoherty U, Swiggard WJ, Inaba K et al. Tolerizingmice to human leukocytes: a step toward the production ofmonoclonal antibodies specific for human dendritic cells.Adv Exp M ed Biol, 1993; 329 1652
7、Thomas R, Davis LS, Lipsky PE. Isolation and character-ization of human peripheral blood dendritic cells. J Im-munol, 1993; 1508213 Egner W, Andressen R, Hart DNJ. Allostimulatory cellsin fresh human blood: heterogeneity in antigen-presentingcell poplulations. Transplantation, 1993; 56 9454 Egner W,
8、 Prickett TCR, Hart DNJ. Adhesion moleculeexpression: a comparison of human blood dendritic cellsmonocytes, and macrophages. Trans Proc, 1992; 2423185 Wood GS, Freudenthal RS. CD5 monoclonal antibody re-acts with human peripheral blood dendritic cells. Am JPathol, 1992; 141 7896 Zhou LJ, Schwarting
9、R, Smith HM et al. A novel cell-surface molecule expressed by human interdigitating retic-ulum cells, Langerhans, cells and activated lymphocytesis a new member of the immunoglobulin superfamily. JImmunol, 1992; 149 7357 Kozlow EJ, Wilson GL, Fox CH et al. Subtractive cDNAcloning of a novel member o
10、f the Ig gene superfamily ex-pressed at high levels in activated B lymphocytes. Blood,1993; 81 4548 Zhou LJ, Tedder TF. Human blood dendritic cells selec-tively express CD83, a memeber of the immunoglobulinsuperfamily. J Immunol, 1995; 154 38219 Barratt-boyes SM, Henderson RA, Finn OJ. Chimpanzeedendriticcells with potentimmunostimulatory function canbe propagated from peripheral blood. Immunology, 1996;87 52810 Schwartz RH. A cell culture model for T lymphocyteclonal anergy. Sciency, 1990; 248 134911 Freeman GJ, Borr
