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1、Concurrent SessionsS21 I-57 Emerging Bartonella in animal and human in China Q.Y. Liu1,2*, F. Zhao1. 1National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China, 2State Key Laboratory for Infectious Disease Prevention and Con
2、trol, Beijing, China Objective:ToinvestigatetheemergingBartonella infections in animal and human for further research and public health response in China. Methods: The authors have reviewed the Chinese literature ofclinicaldiagnosis,andecologicalandlaboratory investigations on Bartonella infections
3、in China between 1980 and 2006, analyzed the characteristics of Bartonella agents and the current situation of Bartonella infection in China. Results: It was found that cat scratch disease (CSD) is the main bartonellosis diagnosed based on clinical manifestations and routine pathologic examination i
4、n China, and the surveillance studies mostly focused on pet animals, rodents and arthropods which might be determined to be the possible source of infection of Bartonella. Twelve isolates of Bartonella were grown from blood of 64 cats from Shandong Province. The seroprevalence of B. henselae antibod
5、ies in cats from Shandong and Henan provinces was 29.6%, including 19.3% in kittens that were younger than 6 months and these numbers doubled in older cats (2 year old). Two isolates were identifi ed as Bartonella vinsonii berkhoffi i from blood specimens of domestic dogs in urban areas of Shandong
6、province. Other research demonstrated the presence of Bartonella in a variety of rodents, such as the family Rattus, Apodemus and Eothenomys. Subsequent studies expanded further the list of rodents infected with Bartonella and extended the geography of their distribution. The data on association of
7、Bartonella with Suncus murinus are particularly important since around 20% of small commensal mammals trapped in south-eastern China are S. murinus. Beijing is the most northern area where Bartonella were isolated from the blood of Rattus norvegicus. Preliminary identifi cation of the Bartonella iso
8、lates from Chinese rodents established the presence of multiple genotypes based on differences in nucleotide sequences of the 325 bp fragment of the conserved gene encoding for citrate synthase (gltA). Most of the Yunnan isolates from R. fl avipectus, R. norvegicus, A. chevrieri, A. draco, and A. la
9、tronum are identifi ed to be B. elizabethae and B. grahamii. Some papers have reported the detection of Bartonella in association with fl eas or ticks from dogs, cats or cows. And they may be potential vectors responsible for transmission of Bartonella in areas where infected animals are present in
10、high prevalence. Conclusion: The fi ndings indicate the emerging Bartonella exists in animal and human in China mainland. This needsfurtherassessmentforpublicawarenessand preparedness. The development and implementation of specifi c and sensitive diagnostic assays is urgently required for establishi
11、ng a state surveillance and diagnostic capacity by the reference diagnostic laboratories. Further studies will be needed to establish the specifi c genotype of the Chinese isolates, and to understand their reservoir association, mode of transmission, spectrum of diseases, and pathological conditions
12、 they may cause in mammals. Current knowledge on Bartonella species and bartonelloses found in mainland China and their role as causes of febrile illness in China are presented as guides for local physicians in China and for travel medicine physicians and tourists abroad. I-58 More and more human an
13、d animal coronaviruses P.C.Y. Woo*. Department of Microbiology, The University of Hong Kong, Hong Kong, China The recent SARS epidemic in 2003 has boosted interests in discovery of novel coronaviruses in both humans and animals. Two novel human coronaviruses, human coronavirus NL63, a novel group 1
14、human coronavirus; and human coronavirus HKU1, a novel group 2 human coronavirus; were reported in 2004 and 2005 respectively. As for animal coronaviruses, we and others have described the discovery of SARS-CoV-like viruses in horseshoe bats in Hong Kong and other provinces of China. In addition, nu
15、merous other novel coronaviruses in bats as well as other animals, such as giraffe, turkey and beluga whale, have been discovered. These discoveries and comparative genomics studies have led to proposal of novel subgroups of coronaviruses. Recently,wehavealsodevelopedacomprehensive database, CoVDB (
16、http:/covdb.microbiology.hku.hk), of annotated coronavirus genes and genomes, for rapid and accurate batch sequence retrieval, the cornerstone and bottleneck for comparative gene or genome analysis. With these, we will be able to get a more in-depth understanding on coronavirus phylogeny. I-59 The interaction between M1 protein of infl uenza virus and host cell factors X.L. Liu, W.J. Liu*. Center for Molecular Virology, Department of pathogenic Microbiology, Institute of Microbiology, Chinese A
