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1、Copyright belong to ECCMID Conference Any business purposes is forbidden Copyright belong to ECCMID Conference Any business purposes is forbidden European Congress of European Congress of Clinical Microbiology Clinical Microbiology and Infectious and Infectious DiseasesDiseases 2015 252015 25th th E
2、CCMID Demark Copenhagen ECCMID Demark Copenhagen Challenge in Invasive fungal infection after solid organ transplant 实体器官移植患者移植后侵袭性真菌感染的挑战 作者利益关系披露作者利益关系披露 Copyright belong to ECCMID Conference Any business purposes is forbidden Copyright belong to ECCMID Conference Any business purposes is forbidde
3、n European Congress of European Congress of Clinical Microbiology Clinical Microbiology and Infectious and Infectious DiseasesDiseases 最近的一年内作者所获得支持和演讲机会 作者作为 Astellas Gilead Merck Novartis Pfizer 讲者 顾问 作者作为 Astellas Gilead Merck Novartis Pfizer 讲者 顾问 本次演讲内容不存在任何利益关系的干扰 实体实体器官移植器官移植 受体受体 Copyright b
4、elong to ECCMID Conference Any business purposes is forbidden Copyright belong to ECCMID Conference Any business purposes is forbidden European Congress of European Congress of Clinical Microbiology Clinical Microbiology and Infectious and Infectious DiseasesDiseases n 复杂和易排异患者 器官功能衰竭 危重的手术后患者 细胞和体液
5、免疫抑制患者 免疫调节状态下的合并感染 CMV EBV HCV 药物毒性和药物相互作用的高风险 n 患者本身和社会的高期望值 健康护理团队的高要求 不同类型移植患者真菌感染发病率不同类型移植患者真菌感染发病率 Copyright belong to ECCMID Conference Any business purposes is forbidden Copyright belong to ECCMID Conference Any business purposes is forbidden European Congress of European Congress of Clinica
6、l Microbiology Clinical Microbiology and Infectious and Infectious DiseasesDiseases 小肠移植小肠移植 11 6 11 6 肺移植肺移植 8 6 8 6 肝脏移植肝脏移植 4 7 4 7 心脏移植心脏移植 3 4 3 4 肾脏移植肾脏移植 1 3 1 3 Pappas PG et al Clin Infect Dis 2010 50 1101 11 累积感染率 累积感染率 小肠 肺 肝脏 胰腺 心脏 肾脏 总体 小肠 肺 肝脏 胰腺 心脏 肾脏 移植后时间移植后时间 天天 晚晚发感染和不寻常的临床表现发感染和不寻
7、常的临床表现 Copyright belong to ECCMID Conference Any business purposes is forbidden Copyright belong to ECCMID Conference Any business purposes is forbidden European Congress of European Congress of Clinical Microbiology Clinical Microbiology and Infectious and Infectious DiseasesDiseases J Heart Lung Transplant 2009 Rev Iberoam Micol 2011 一例心脏移植患者术后罹患前列腺曲霉菌病 病例报道和相关回顾一例心脏移植患者术后罹患前列腺曲霉菌病 病例报道和相关回顾 心脏移植患者心脏侵袭曲霉菌病心脏移植患者心脏侵袭曲霉菌病
