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1、Cholesterol SterolToolkit Pregnenolon Progesteron Aldosteron Cortisol Corticosterone Androstendione Testosteron Estriol 17 Estradiol 1 25 Dihydroxycholecalciferol Cholicacid CovalentmodificationofproteinsPoly ADPribosyl Polymerase PARP Poly ADPribosyl polymerase PARP NAD Nicotinamide Poly ADPribosyl
2、 polymerase PARP Poly ADPribosyl chainelongationandbranching Nicotinamide NAD NAD DNApolymerase DNApolymerase DNApolymerase Oligosacharyltransferase N glycosylationpathwayinER Mann P Dolicholtransferases Flippase Dolichol P P Dolichol P P Dolichol P P Dolichol P P GlcNAc Ptransferase GlcNActransfera
3、se Dolichol P GDP Mannosyltransferases Glc P Dolicholtransferases Dolichol pyrophofphatase Cytosol ER 40S 60S UTP CTP TMP PyrimidineNucleotideInterconversions UMP ATP ADP H2O UDP Nucleosidemonophosphatekinase ATP ADP Nucleosidediphosphatekinase ATP ADP CTPsynthase Ribonucleotidereductase deoxyUDP Nu
4、cleosidediphosphatephosphohydrolase deoxyUMP Thymidylatesynthase N5 N10 MethyleneTHF DHF TTP Nucleosidemonophosphatekinase Nucleosidediphosphatekinase Myo Inositol 3 phosphateIns 3 P1 Biosynthesisandmetabolismofphosphoinositides Glucose6 pgosphate Ins 3 P1synthase Ins 3 P1phosphatase Myo InositolIns
5、 PtdInssynthase PtdIns Myo inositolkinase PtdIns 4 P PtdIns4 kinase PtdIns5 kinase PtdIns 4 5 P2 PI3K PtdIns 3 4 5 P3 PLC PLC PI3K PtdIns 3 4 P2 Ins 1 3 4 P3 Ins 1 3 4 5 P4 Ins 1 4 5 P3 PLC PTEN PTEN Ins 1 4 P3 PTEN PTEN Fattyacidsynthase ketoacylACP synthase Fattyacidssynthesis AcetylCoAcarboxylase
6、 ATP ADP Pi AcetylCoA MalonylCoA Citrate Oxaloacetate ATP ADP Pi Citratelyase Acetyltransacylase Malonyltransacylase ketoacylACP reductase hydroxyacylACP dehydratase Enoyl ACPreductase Pantetheine NADPH NADP NADPH NADP CholesteroldenovosynthesisIIsoprenylformation Acetoacetyl CoA Thiolase HMG CoAsyn
7、thase Mevalonate 3 Hydroxy 3 methylglutaryl CoA Mevalonatekinase Phosphomevalonatekinase Mevalonate 5 pyrophosphodecarboxylase 5 Phosphomevalonate 5 Pyrophosphomevalonate 3 Isopentenylpyrophosphate 3 3 Dimethylalylpyrophosphate Isomerase HMG CoAreductase 2NADPH 2NADP ATP ADP ADP ATP ADP ATP Choleste
8、rol Biosynthesisofbileacids 7 Hydroxycholesterol Sterol7 hydroxylaseCYP7A1 7 Hydroxy 4 cholesten 3 one 3 HydroxystroiddehydrogenaseHSD3B7 7 12 Dihydroxy 4 cholesten 3 one Sterol 12 hydroxylaseCYP8B1 5 Cholestan 3 7 12 Triol Oxosteroid 5 reductaseAKR1D1 Sterol27 hydroxylaseCYP27A1 3 7 12 Trihydroxy 5
9、 cholestanoicacid AKR1D1AKR1C4 5 Cholestan 3 7 diol 12 Deoxycholicacid 3 Hydroxy steroiddehydrogenaseAKR1C4 BiosynthesisofRNA RNAPolymerase BiosynthesisofDNA DNAPolymerase oxidation Mitochondrialmatrix Intermembranespace PalmitoylCoA PalmitoylCoA Trans 2enolopalmitoylCoA 3 HydroxypalmitoylCoA 3 Keto
10、palmitoylCoA MyristoylCoA Acetyl CoA PalmitoylCoA PalmitoylCoAligase ATP AMP CarnitineacyltransferaseI CarnitineacyltransferaseII AcylCoAdehydrogenase EnoylCoAhydratase 3 HydroxyacylCoAdehydrogenase CitricAcidCycle FAD FADH2 NAD NADH Cytoplasm H2O Myo Inositol 3 phosphateIns 3 P1 Phospho myo inosito
11、lToolkit2 Myo Inositol 3 4 diphosphateIns 3 4 P2 Myo Inositol 3 6 diphosphateIns 3 6 P2 Myo Inositol 3 4 6 triphosphateIns 3 4 6 P3 Myo Inositol 1 3 4 triphosphateIns 1 3 4 P3 Myo Inositol 3 4 5 6 tetraphosphateIns 3 4 5 6 P4 Myo Inositol 1 4 5 triphosphateIns 1 4 5 P3 Myo Inositol 1 3 4 6 tetraphos
12、phateIns 1 3 4 6 P4 Myo Inositol 1 3 4 5 tetraphosphateIns 1 3 4 5 P4 Myo Inositol 1 4 5 6 tetraphosphateIns 1 4 5 6 P4 Myo Inositol 1 2 3 4 6 pentaphosphateIns 1 2 3 4 6 P5 Myo Inositol 1 3 4 5 6 pentaphosphateIns 1 3 4 5 6 P5 Myo Inositol 1 2 3 4 5 pentaphosphateIns 1 2 3 4 5 P5 Myo Inositol 1 2 4
13、 5 6 pentaphosphateIns 1 2 4 5 6 P5 Myo Inositol 1 2 3 4 5 6 hexaphosphateIns 1 2 3 4 5 6 P6 Phyticacid Myo Inositol 3 phosphateIns 3 P1 Phospho myo inositolToolkit Myo Inositol 3 4 diphosphateIns 3 4 P2 Myo Inositol 3 6 diphosphateIns 3 6 P2 Myo Inositol 3 4 6 triphosphateIns 3 4 6 P3 Myo Inositol
14、1 3 4 triphosphateIns 1 3 4 P3 Myo Inositol 3 4 5 6 tetraphosphateIns 3 4 5 6 P4 Myo Inositol 1 4 5 triphosphateIns 1 4 5 P3 Myo Inositol 1 3 4 6 tetraphosphateIns 1 3 4 6 P4 Myo Inositol 1 3 4 5 tetraphosphateIns 1 3 4 5 P4 Myo Inositol 1 4 5 6 tetraphosphateIns 1 4 5 6 P4 Myo Inositol 1 2 3 4 6 pe
15、ntaphosphateIns 1 2 3 4 6 P5 Myo Inositol 1 3 4 5 6 pentaphosphateIns 1 3 4 5 6 P5 Myo Inositol 1 2 3 4 5 pentaphosphateIns 1 2 3 4 5 P5 Myo Inositol 1 2 4 5 6 pentaphosphateIns 1 2 4 5 6 P5 Myo Inositol 1 2 3 4 5 6 hexaphosphateIns 1 2 3 4 5 6 P6 Phyticacid Glycogen Glycogenin 8 oxoguanine AcommonD
16、NAlesionsToolkitI O6 methylguanine Uracil Thymineglycol 1 N6 ethenoadenine 3 methyladenine Cyclobutanepyrimidinedimers Photoadduct Ribose Glucuronate Arabinose Fructose Glucose Galactose Mannose Fucose SialicAcid Inositol D Abequose L Rhamnose Acarbohydratetoolkit PGH2 TXA2 TXB2 Bioactivelipids Prostanoids PGD2 PGJ2 PGE2 PGA2 PGB2 PGF2 PGF M PGI2 6 keto PGF1 Bioactivelipids Leukotrienes 5 HETE LTA4 LTB4 LTC4 LTD4 LTE4 20 OH LTE4 LXA4 LTB4 LTF4 LXA LXB Bioactivelipids Arachidonate Ceramide Sphing
